The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application
Open accessAbstract
Infectious diseases are a major global health issue. Diagnosis is a critical first step in effectively managing their spread. Paper-based microfluidic diagnostics first emerged in 2007 as a low-cost alternative to conventional laboratory testing, with the goal of improving accessibility to medical diagnostics in developing countries. In this review, we examine the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016. The theory of fluid transport in paper is first presented. The next section examines the strategies that have been employed to control fluid and analyte transport in paper-based assays. Tasks such as mixing, timing, and sequential fluid delivery have been achieved in paper and have enabled analytical capabilities comparable to those of conventional laboratory methods. The following section examines paper-based sample processing and analysis. The most impactful advancement here has been the translation of nucleic acid analysis to a paper-based format. Smartphone-based analysis is another exciting development with potential for wide dissemination. The last core section of the review highlights emerging health applications, such as male fertility testing and wearable diagnostics. We conclude the review with the future outlook, remaining challenges, and emerging opportunities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
The Dynamics of Capillary Flow
Washburn, E. W. (1921) · Physical Review · doi:10.1103/physrev.17.273 · Cited by 7,141
A comprehensive review on PEM water electrolysis
Carmo, M., Fritz, D. L., Mergel, J., & Stolten, D. (2013) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2013.01.151 · Cited by 5,492
Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,277
Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,182
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Hydrogels in drug delivery: Progress and challenges
Hoare, T. R., & Kohane, D. S. (2008) · Polymer · doi:10.1016/j.polymer.2008.01.027 · Cited by 3,776
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995
Patterned Paper as a Platform for Inexpensive, Low‐Volume, Portable Bioassays
Martinez, A. W., Phillips, S. T., Butte, M. J., & Whitesides, G. M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603817 · Cited by 2,874
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703
Cited by
Device integration of electrochemical biosensors
Wu, J., Liu, H., Chen, W., Ma, B., & Ju, H. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00032-w · Cited by 895
Microfluidics: Innovations in Materials and Their Fabrication and Functionalization
Nielsen, J. B., Hanson, R. L., Almughamsi, H. M., Pang, C., Fish, T. R., & Woolley, A. T. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04986 · Cited by 359
Beyond the lateral flow assay: A review of paper-based microfluidics
Carrell, C., Kava, A., Nguyen, M., Menger, R., Munshi, Z., Call, Z., Nussbaum, M., & Henry, C. (2019) · Microelectronic Engineering · doi:10.1016/j.mee.2018.12.002 · Cited by 336
Maeki, M., Kimura, N., Sato, Y., Harashima, H., & Tokeshi, M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.03.008 · Cited by 319
Metadata
- Authors
- Gong, M. M., & Sinton, D.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-06-19
- Volume
- 117
- Issue
- 12
- Pages
- 8447-8480
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2642522075
- Cited by
- 573
- References
- 165
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application. https://app.cochat.ai/papers/10.1021/acs.chemrev.7b00024
- The paper
- Gong, M. M., & Sinton, D. (2017). Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.7b00024
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
