Cited by 2,703Hydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Hydrogels in regenerative medicine

Open access
Slaughter, Brandon V., Khurshid, Shahana S., Fisher, Omar Z., Khademhosseini, Ali, Peppas, Nicholas A.·2009·Advanced Materials

Abstract

Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.

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  • Spheroid cell culture has been developed for research on cancer, stem cells, and many organs, including liver, kidney, and heart.

    “This approach has been developed in the research of cancer (7, 76, 102), stem cells (17, 120), and many organs (such as liver, kidney, heart, etc.) (3,16,64,75).”

    From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [102]

    Section 6.1 describes a miniature liverlike construct made from collagen rods, and Section 6.3 describes stem cells cultured within spherical hydrogel microgels. Neither establishes that spheroid cell culture was developed for research on liver, kidney, heart, or the other named subjects. Searches for “spheroid,” “kidney,” and “heart” found no passage establishing that claim; page numbers were unavailable. (LLM, conf=0.73)

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Research works printed but not linked: 11

  1. [25]Renkin LF J Gen. Physiol 1954 38 225 13211998 PMC2147404
  2. [44]Hillwest JL Chowdhury SM Slepian MJ Hubbell JA Proc. Natl. Acad. Sci. USA 1994 91 5967 8016098 PMC44118
  3. [46]HillWest JL Dunn RC Hubbell JA J Surg. Res 1995 59 759 8538178
  4. [145]Varghese S Elisseeff JH Werner C Polymers for Regenerative Medicine Advances in Polymer Science 2006 203 Berlin Springer 95
  5. [171]Ostuni E Chapman RG Holmlin RE Takayama S Whitesides GM Langmuir 2001 17 5605 34139796
  6. [187]Smidsrod O Skjakbraek G Trends Biotechnol 1990 8 71 1366500
  7. [202]Waldrone D Paul TM Skoryna SC Nature 1965 205 1117 5833216
  8. [205]Mullerglauser W Humbel B Glatt M Strauli P Winterhalter KH Bruckner P J Cell Biol 1986 102 1931 3517011 PMC2114213
  9. [212]Lucas PA Syftestad GT Goldberg VM Caplan AI J Biomed. Mater. Res, Part B 1989 23 23 2722904
  10. [249]Grayson ACR Shawgo RS Johnson AM Flynn NT Li Y Cima MJ Langer R Proc. IEEE 2004 92 6
  11. [258]Leach JB Bivens KA Patrick CW Jr Schmidt CE Biotechnol. Bioeng 2003 82 578 12652481

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Authors
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A.
Affiliations
  • The University of Texas at Austin (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Peppas, Nicholas A.
Venue
Advanced Materials
Publisher
Wiley
Published
2009-08-28
Volume
21
Issue
32-33
Pages
3307-3329
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2171311487
Cited by
2,703
References
282
Citations by year
2026: 72 · 2025: 126 · 2024: 125 · 2023: 156 · 2022: 180 · 2021: 202 · 2020: 188 · 2019: 227 · 2018: 191 · 2017: 181 · 2016: 167 · 2015: 197 · 2014: 171 · 2013: 202 · 2012: 150
FWCI
49.74
Type
journal article
Language
en
Open access
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01eb000246-20)
  • National Cancer Institute (U54CA143837)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB012726, R01-EB000246)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
hydrogels, regenerative medicine, tissue engineering scaffolds, drug delivery, protein delivery, tissue adhesives, hydrogel synthesis, biocompatibility

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