Hydrogels in regenerative medicine
Open accessAbstract
Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.
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Spheroid cell culture has been developed for research on cancer, stem cells, and many organs, including liver, kidney, and heart.
“This approach has been developed in the research of cancer (7, 76, 102), stem cells (17, 120), and many organs (such as liver, kidney, heart, etc.) (3,16,64,75).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [102]
Section 6.1 describes a miniature liverlike construct made from collagen rods, and Section 6.3 describes stem cells cultured within spherical hydrogel microgels. Neither establishes that spheroid cell culture was developed for research on liver, kidney, heart, or the other named subjects. Searches for “spheroid,” “kidney,” and “heart” found no passage establishing that claim; page numbers were unavailable. (LLM, conf=0.73)
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A mini review on hydrogels classification and recent developments in miscellaneous applications
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Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
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Research Progress of Shape Memory Polymer and 4D Printing in Biomedical Application
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Ex Vivo Culture of Primary Intestinal Stem Cells in Collagen Gels and Foams
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- Authors
- Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A.
- Affiliations
- The University of Texas at Austin (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Peppas, Nicholas A.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2009-08-28
- Volume
- 21
- Issue
- 32-33
- Pages
- 3307-3329
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- PMC
- PMC4494665
- OpenAlex
- W2171311487
- Cited by
- 2,703
- References
- 282
- Citations by year
- 2026: 72 · 2025: 126 · 2024: 125 · 2023: 156 · 2022: 180 · 2021: 202 · 2020: 188 · 2019: 227 · 2018: 191 · 2017: 181 · 2016: 167 · 2015: 197 · 2014: 171 · 2013: 202 · 2012: 150
- FWCI
- 49.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01eb000246-20)
- National Cancer Institute (U54CA143837)
- National Institute of Biomedical Imaging and Bioengineering (R21EB012726, R01-EB000246)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- hydrogels, regenerative medicine, tissue engineering scaffolds, drug delivery, protein delivery, tissue adhesives, hydrogel synthesis, biocompatibility
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