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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules

Open access
Schrittwieser, Joerg H., Velikogne, Stefan, Hall, Mélanie, Kroutil, Wolfgang·2018·Chemical Reviews

Abstract

The review compiles artificial cascades involving enzymes with a focus on the last 10 years. A cascade is defined as the combination of at least two reaction steps in a single reaction vessel without isolation of the intermediates, whereby at least one step is catalyzed by an enzyme. Additionally, cascades performed in vivo and in vitro are discussed separately, whereby in vivo cascades are defined here as cascades relying on cofactor recycling by the metabolism or on a metabolite from the living organism. The review introduces a systematic classification of the cascades according to the number of enzymes in the linear sequence and differentiates between cascades involving exclusively enzymes and combinations of enzymes with non-natural catalysts or chemical steps. Since the number of examples involving two enzymes is predominant, the two enzyme cascades are further subdivided according to the number, order, and type of redox steps. Furthermore, this classification differentiates between cascades where all reaction steps are performed simultaneously, sequentially, or in flow.

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Metadata

Authors
Schrittwieser, J. H., Velikogne, S., Hall, M., & Kroutil, W.
Venue
Chemical Reviews
Published
2017-05-08
Volume
118
Issue
1
Pages
270-348
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2613083880
Cited by
634
References
5
FWCI
5.00
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules. https://app.cochat.ai/papers/10.1021/acs.chemrev.7b00033
The paper
Schrittwieser, J. H., Velikogne, S., Hall, M., & Kroutil, W. (2018). Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.7b00033

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