Cited by 174Glycosylation and Glycoproteins ResearchMicrofluidic and Capillary Electrophoresis ApplicationsCarbohydrate Chemistry and Synthesis

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Capillary Electrophoresis Separations of Glycans

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Lu, Grace, Crihfield, Cassandra L., Gattu, Srikanth, Veltri, Lindsay M., Holland, Lisa A.·2018·Chemical Reviews

DOI 10.1021/acs.chemrev.7b00669PMC PMC6135675

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Abstract

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses since 2014. The method provides high resolution capable of separating carbohydrates by charge-to-size ratio. Principle applications are heavily focused on N-glycans, which are highly relevant to biological therapeutics and biomarker research. Advances in techniques used for N-glycan structural identification include migration time indexing and exoglycosidase and lectin profiling, as well as mass spectrometry. Capillary electrophoresis methods have been developed that are capable of separating glycans with the same monosaccharide sequence but different positional isomers, as well as determining whether monosaccharides composing a glycan are alpha or beta linked. Significant applications of capillary electrophoresis to the analyses of N-glycans in biomarker discovery and biological therapeutics are emphasized with a brief discussion included on carbohydrate analyses of glycosaminoglycans and mono-, di-, and oligosaccharides relevant to food and plant products. Innovative, emerging techniques in the field are highlighted and the future direction of the technology is projected based on the significant contributions of capillary electrophoresis to glycoscience from 2014 to the present as discussed in this review.

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Authors: Lu, G., Crihfield, C. L., Gattu, S., Veltri, L. M., & Holland, L. A.
Affiliations: West Virginia University (US)
Corresponding author: Holland, Lisa A.
ORCID: Lu, Grace
Holland, Lisa A.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2018-03-12
Volume: 118
Issue: 17
Pages: 7867-7885
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/acs.chemrev.7b00669
PMC: PMC6135675
OpenAlex: W2790011125
Cited by: 174
References: 148
Citations by year: 2026: 15 · 2025: 14 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 31 · 2020: 25 · 2019: 17 · 2018: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
pubs.acs.org/page/policy/authorchoice_termsofuse.html (vor)
Locations: Chemical Reviews (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM114330)
Division of Graduate Education (DGE-1144676)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords: capillary electrophoresis, glycans, N-glycans, carbohydrate analysis, regioisomers, biomarker discovery, biologic therapy, glycosaminoglycans, oligosaccharides, dietary carbohydrates, glycoscience
MeSH terms: Carbohydrate Conformation, Monosaccharides, Oligosaccharides, Polysaccharides, Pyrenes, Staining and Labeling, Electrophoresis, Capillary, High-Throughput Screening Assays

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Capillary Electrophoresis Separations of Glycans

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