The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Capillary Electrophoresis Separations of Glycans
Open accessAbstract
Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses since 2014. The method provides high resolution capable of separating carbohydrates by charge-to-size ratio. Principle applications are heavily focused on N-glycans, which are highly relevant to biological therapeutics and biomarker research. Advances in techniques used for N-glycan structural identification include migration time indexing and exoglycosidase and lectin profiling, as well as mass spectrometry. Capillary electrophoresis methods have been developed that are capable of separating glycans with the same monosaccharide sequence but different positional isomers, as well as determining whether monosaccharides composing a glycan are alpha or beta linked. Significant applications of capillary electrophoresis to the analyses of N-glycans in biomarker discovery and biological therapeutics are emphasized with a brief discussion included on carbohydrate analyses of glycosaminoglycans and mono-, di-, and oligosaccharides relevant to food and plant products. Innovative, emerging techniques in the field are highlighted and the future direction of the technology is projected based on the significant contributions of capillary electrophoresis to glycoscience from 2014 to the present as discussed in this review.
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“Glycosylation is an important and common PTM in biological systems, but its detailed characterization is challenging because of its heterogeneity in localization and forms76–79.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [78]
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“While many CE-based techniques have been reported for the analysis of proteins and peptides, CZE is the most commonly used in proteomics research10,64–66.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [65]
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“tITP requires an optimization of both electrolyte concentrations and loading volume to enable efficient stacking of the target analytes13,27,65,120–122.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [65]
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Metadata
- Authors
- Lu, G., Crihfield, C. L., Gattu, S., Veltri, L. M., & Holland, L. A.
- Affiliations
- West Virginia University (US)
- Corresponding author
- Holland, Lisa A.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-03-12
- Volume
- 118
- Issue
- 17
- Pages
- 7867-7885
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC6135675
- OpenAlex
- W2790011125
- Cited by
- 174
- References
- 148
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 31 · 2020: 25 · 2019: 17 · 2018: 9
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Chemical Reviews (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM114330)
- Division of Graduate Education (DGE-1144676)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- capillary electrophoresis, glycans, N-glycans, carbohydrate analysis, regioisomers, biomarker discovery, biologic therapy, glycosaminoglycans, oligosaccharides, dietary carbohydrates, glycoscience
- MeSH terms
- Carbohydrate Conformation, Monosaccharides, Oligosaccharides, Polysaccharides, Pyrenes, Staining and Labeling, Electrophoresis, Capillary, High-Throughput Screening Assays
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