The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status
Abstract
Human ingestion of microplastics (MPs) is inevitable due to the ubiquity of MPs in various foods and drinking water. Whether the ingestion of MPs poses a substantial risk to human health is far from understood. Here, by analyzing the characteristics of MPs in the feces of patients with inflammatory bowel disease (IBD) and healthy people, for the first time, we found that the fecal MP concentration in IBD patients (41.8 items/g dm) was significantly higher than that in healthy people (28.0 items/g dm). In total, 15 types of MPs were detected in feces, with poly(ethylene terephthalate) (22.3-34.0%) and polyamide (8.9-12.4%) being dominant, and their primary shapes were sheets and fibers, respectively. We present evidence indicating that a positive correlation exists between the concentration of fecal MPs and the severity of IBD. Combining a questionnaire survey and the characteristics of fecal MPs, we conclude that the plastic packaging of drinking water and food and dust exposure are important sources of human exposure to MPs. Furthermore, the positive correlation between fecal MPs and IBD status suggests that MP exposure may be related to the disease process or that IBD exacerbates the retention of MPs. The relative mechanisms deserve further studies. Our results also highlight that fecal MPs are useful for assessing human MP exposure and potential health risks.
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Cites
Plasticenta: First evidence of microplastics in human placenta
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Human Consumption of Microplastics
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Environmental exposure to microplastics: An overview on possible human health effects
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The global burden of IBD: from 2015 to 2025
Kaplan, G. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.150 · Cited by 2,639
Genetics and pathogenesis of inflammatory bowel disease
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Microplastics in Freshwaters and Drinking Water: Critical Review and Assessment of Data Quality
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Cited by
Twenty years of microplastic pollution research—what have we learned?
Thompson, R. C., Courtene-Jones, W., Boucher, J., Pahl, S., Raubenheimer, K., & Koelmans, A. A. (2024) · Science · doi:10.1126/science.adl2746 · Cited by 1,521
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428
Microplastics: Detection in human samples, cell line studies, and health impacts
Barceló, D., Picó, Y., & Alfarhan, A. H. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104204 · Cited by 279
Jiang, H., Bu, J., Bian, K., Su, J., Wang, Z., Sun, H., Wang, H., Zhang, Y., & Wang, C. (2023) · Water Research · doi:10.1016/j.watres.2023.119794 · Cited by 113
Self-citationLi, N., Yang, H., Dong, Y., Wei, B., Liang, L., Yun, X., Tian, J., Zheng, Y., Duan, S., & Zhang, L. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173522 · Cited by 110
Metadata
- Authors
- Yan, Z., Liu, Y., Zhang, T., Zhang, F., Ren, H., & Zhang, Y.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-12-22
- Volume
- 56
- Issue
- 1
- Pages
- 414-421
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W4200605805
- Cited by
- 835
- References
- 53
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, Z., Liu, Y., Zhang, T., Zhang, F., Ren, H., & Zhang, Y. (2022). Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environmental Science & Technology. https://doi.org/10.1021/acs.est.1c03924
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