Uptake and Accumulation of Polystyrene Microplastics in Zebrafish ( Danio rerio ) and Toxic Effects in Liver
Abstract
Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the laboratory, MPs can cross the intestinal barrier, travel through the bloodstream, and reach the liver.
“In the laboratory, it was demonstrated that MPs can cross the intestinal barrier, travel through the bloodstream, and reach the liver [71].”
From Is Wild Marine Biota Affected by Microplastics? (2022) · cites this paper as [71]
Nanoplastics have high surface to volume ratios and thus better adsorb toxic compounds and potentially transfer them to organisms after ingestion.
“Nanoplastics are characterised by high surface to volume ratios and thus better adsorb toxic compounds and potentially transfers them to organisms aer ingestion.16,18,137,[147][148][149]”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [149]
Cites
Accumulation of Microplastic on Shorelines Woldwide: Sources and Sinks
Browne, M. A., Crump, P., Niven, S. J., Teuten, E. L., Tonkin, A., Galloway, T. S., & Thompson, R. C. (2011) · Environmental Science & Technology · doi:10.1021/es201811s · Cited by 4,838 · see citing works
The Physical Impacts of Microplastics on Marine Organisms: A Review
Wright, S. L., Thompson, R. C., & Galloway, T. S. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.02.031 · Cited by 4,524 · see citing works
Microplastic ingestion by zooplankton
Cole, M., Lindeque, P., Fileman, E., Halsband, C., Goodhead, R., Moger, J., & Galloway, T. S. (2013) · Environmental Science & Technology · doi:10.1021/es400663f · Cited by 2,763 · see citing works
Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es800249a · Cited by 2,263 · see citing works
von Moos, N., Burkhardt-Holm, P., & Köhler, A. (2012) · Environmental Science & Technology · doi:10.1021/es302332w · Cited by 1,697 · see citing works
The present and future of microplastic pollution in the marine environment
do Sul, J. A. I., & da Costa, M. F. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.10.036 · Cited by 1,604 · see citing works
Pollutants bioavailability and toxicological risk from microplastics to marine mussels
Avio, C. G., Gorbi, S., Milan, M., Benedetti, M., Fattorini, D., d'Errico, G., Pauletto, M., Bargelloni, L., & Regoli, F. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2014.12.021 · Cited by 1,413 · see citing works
Cole, M., Lindeque, P., Fileman, E., Halsband, C., & Galloway, T. S. (2015) · Environmental Science & Technology · doi:10.1021/es504525u · Cited by 1,308 · see citing works
Browne, M. A., Niven, S. J., Galloway, T. S., Rowland, S. J., & Thompson, R. C. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.012 · Cited by 1,160 · see citing works
Nanoplastic Affects Growth of <i>S. obliquus</i> and Reproduction of <i>D. magna</i>
Besseling, E., Wang, B., Lürling, M., & Koelmans, A. A. (2014) · Environmental Science & Technology · doi:10.1021/es503001d · Cited by 1,138 · see citing works
Interplay between lipids and branched-chain amino acids in development of insulin resistance
Newgard, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.024 · Cited by 1,080 · see citing works
Microplastic ingestion decreases energy reserves in marine worms
Wright, S. L., Rowe, D., Thompson, R. C., & Galloway, T. S. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.068 · Cited by 1,079 · see citing works
Zhao, S., Zhu, L., Wang, T., & Li, D. (2014) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2014.06.032 · Cited by 1,054 · see citing works
Size and shape effects in the biodistribution of intravascularly injected particles
Decuzzi, P., Godin, B., Tanaka, T., Lee, S., Chiappini, C., Liu, X., & Mauro Ferrari, B. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.014 · Cited by 968 · see citing works
Lee, K.-W., Shim, W. J., Kwon, O. Y., & Kang, J.-H. (2013) · Environmental Science & Technology · doi:10.1021/es401932b · Cited by 923 · see citing works
Sharma, V., Anderson, D. C., & Dhawan, A. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0705-6 · Cited by 793 · see citing works
Rochman, C. M., Kurobe, T., Flores, I., & Teh, S. J. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.06.051 · Cited by 762 · see citing works
Uptake and Retention of Microplastics by the Shore Crab <i>Carcinus maenas</i>
Watts, A. J. R., Lewis, C., Goodhead, R. M., Beckett, S. J., Moger, J., Tyler, C. R., & Galloway, T. S. (2014) · Environmental Science & Technology · doi:10.1021/es501090e · Cited by 730 · see citing works
Oliveira, M., Ribeiro, A., Hylland, K., & Guilhermino, L. (2013) · Ecological Indicators · doi:10.1016/j.ecolind.2013.06.019 · Cited by 722 · see citing works
Yang, L., & Watts, D. J. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.03.003 · Cited by 665 · see citing works
Sadri, S., & Thompson, R. C. (2014) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2014.02.020 · Cited by 645 · see citing works
Della Torre, C., Bergami, E., Salvati, A., Faleri, C., Cirino, P., Dawson, K. A., & Corsi, I. (2014) · Environmental Science & Technology · doi:10.1021/es502569w · Cited by 632 · see citing works
Nutritional, Dietary and Postprandial Oxidative Stress
Sies, H., Stahl, W., & Sevanian, A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.969 · Cited by 608 · see citing works
Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles
Mattsson, K., Ekvall, M. T., Hansson, L.-A., Linse, S., Malmendal, A., & Cedervall, T. (2015) · Environmental Science & Technology · doi:10.1021/es5053655 · Cited by 581 · see citing works
Food Chain Transport of Nanoparticles Affects Behaviour and Fat Metabolism in Fish
Cedervall, T., Hansson, L., Lard, M., Frohm, B., & Linse, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032254 · Cited by 555 · see citing works
Distribution of Nanoparticles in the See-through Medaka ( Oryzias latipes )
Kashiwada, S. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9209 · Cited by 524 · see citing works
Chua, E. M., Shimeta, J., Nugegoda, D., Morrison, P. D., & Clarke, B. O. (2014) · Environmental Science & Technology · doi:10.1021/es405717z · Cited by 494 · see citing works
Scientific Evidence Supports a Ban on Microbeads
Rochman, C. M., Kross, S. M., Armstrong, J. B., Bogan, M. T., Darling, E. S., Green, S. J., Smyth, A. R., & Veríssimo, D. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03909 · Cited by 455 · see citing works
Luís, L. G., Ferreira, P., Fonte, E., Oliveira, M., & Guilhermino, L. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.04.018 · Cited by 342 · see citing works
Fate of Microplastics in the Marine Isopod <i>Idotea emarginata</i>
Hämer, J., Gutow, L., Köhler, A., & Saborowski, R. (2014) · Environmental Science & Technology · doi:10.1021/es501385y · Cited by 286 · see citing works
Cytotoxicity evaluation of ceramic particles of different sizes and shapes
Yamamoto, A., Honma, R., SUMITA, M., et al. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.20020 · Cited by 194 · see citing works
Hu, X.-G., Ouyang, S.-H., Mu, L., An, J., & Zhou, Q.-X. (2015) · Environmental Science and Technology · doi:10.1021/acs.est.5b02102 · Cited by 181 · see citing works
Vinaixa, M., Rodriguez, M. A., Rull, A., Beltrán‐Debón, R., Bladé, C., Brezmes, J., Cañellas, N., Joven, J., & Correig, X. (2010) · Journal of Proteome Research · doi:10.1021/pr901203w · Cited by 157 · see citing works
Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish
Samuelsson, L. M., Förlin, L., Karlsson, G., et al. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2006.04.008 · Cited by 135 · see citing works
Urban, R. M., Tomlinson, M. J., Hall, D. J., et al. (2004) · The Journal of Arthroplasty · doi:10.1016/j.arth.2004.09.013 · Cited by 130 · see citing works
Metabolic responses of HeLa cells to silica nanoparticles by NMR-based metabolomic analyses
Feng, J., Li, J., Wu, H., et al. (2013) · Metabolomics · doi:10.1007/s11306-013-0499-8 · Cited by 85 · see citing works
Figueiredo-Silva, A. C., Kaushik, S., Terrier, F., Schrama, J. W., Médale, F., & Geurden, I. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004739 · Cited by 82 · see citing works
Wu, B., Liu, S., Guo, X., Zhang, Y., Zhang, X., Li, M., & Cheng, S. (2012) · Environmental Science & Technology · doi:10.1021/es301804t · Cited by 78 · see citing works
Self-citationGallego‐Ortega, D., del Pulgar, T. G., Valdés‐Mora, F., et al. (2010) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2010.09.010 · Cited by 60 · see citing works
Li, J., Zhao, Z., Feng, J., et al. (2013) · Nanotechnology · doi:10.1088/0957-4484/24/45/455102 · Cited by 58 · see citing works
Yang, B., Jin, C., Liu, Y., Yu, W., & Kang, H. (2014) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2014.939321 · Cited by 56 · see citing works
SUGIYAMA, K., Akai, H., & MURAMATSU, K. (1986) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.32.537 · Cited by 49 · see citing works
Preparation of fluorescent polystyrene microspheres by gradual solvent evaporation method
Zhang, Q., Han, Y. X., Wang, W.-C., et al. (2008) · European Polymer Journal · doi:10.1016/j.eurpolymj.2008.11.016 · Cited by 46 · see citing works
Effect of acute and chronic branched-chain amino acids on energy metabolism and muscle performance.
LORENZO, A. D., Petroni, M. L., Masala, S. A., Melchiorri, G., Pietrantuono, M., Perriello, G., & Andréoli, A. (2003) · PubMed · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Environmental exposure to microplastics: An overview on possible human health effects
Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134455 · Cited by 2,690 · see citing works
Auta, H. S., Emenike, C. U., & Fauziah, S. H. (2017) · Environment International · doi:10.1016/j.envint.2017.02.013 · Cited by 2,649 · see citing works
Deng, Y., Zhang, Y., Lemos, B., & Ren, H. (2017) · Scientific Reports · doi:10.1038/srep46687 · Cited by 1,471 · see citing works
Self-citationde Sá, L. C., Oliveira, M., Ribeiro, F., Rocha, T. L., & Futter, M. N. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.207 · Cited by 1,316 · see citing works
Emergence of Nanoplastic in the Environment and Possible Impact on Human Health
Lehner, R., Weder, C., Petri-Fink, A., & Rothen-Rutishauser, B. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b05512 · Cited by 1,242 · see citing works
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.08.353 · Cited by 1,100 · see citing works
A review of microplastics in table salt, drinking water, and air: direct human exposure
Zhang, Q., Xu, E. G., Li, J., Chen, Q., Ma, L., Zeng, E. Y., & Shi, H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b04535 · Cited by 1,064 · see citing works
Abbasi, S., Keshavarzi, B., Moore, F., Turner, A., Kelly, F. J., Dominguez, A. O., & Jaafarzadeh, N. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2018.10.039 · Cited by 770 · see citing works
Ding, J., Zhang, S., Razanajatovo, R. M., Zou, H., & Zhu, W. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.001 · Cited by 766 · see citing works
Plastic Debris in 29 Great Lakes Tributaries: Relations to Watershed Attributes and Hydrology
Baldwin, A. K., Corsi, S. R., & Mason, S. A. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b02917 · Cited by 739 · see citing works
Recent advances in toxicological research of nanoplastics in the environment: A review
Shen, M., Zhang, Y., Zhu, Y., Song, B., Zeng, G., Hu, D., Wen, X., & Ren, X. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.102 · Cited by 686 · see citing works
Self-citationMiller, M. E., Hamann, M., & Kroon, F. J. (2020) · PLOS ONE · doi:10.1371/journal.pone.0240792 · Cited by 657 · see citing works
Amelia, T. S. M., Khalik, W. M. A. W. M., Ong, M. C., Shao, Y. T., Pan, H.-J., & Bhubalan, K. (2021) · Progress in Earth and Planetary Science · doi:10.1186/s40645-020-00405-4 · Cited by 641 · see citing works
Rist, S., Baun, A., & Hartmann, N. B. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.05.048 · Cited by 571 · see citing works
Micro- and nanoplastic toxicity on aquatic life: Determining factors
Kögel, T., Bjorøy, Ø., Toto, B., Bienfait, A. M., & Sanden, M. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.136050 · Cited by 518 · see citing works
Methods for the analysis of submicrometer- and nanoplastic particles in the environment
Schwaferts, C., Niessner, R., Elsner, M., & Ivleva, N. P. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.12.014 · Cited by 522 · see citing works
Liang, B., Zhong, Y., Huang, Y., Lin, X., Liu, J., Lin, L., Hu, M., Jiang, J., Dai, M., Wang, B., et al. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00414-1 · Cited by 508 · see citing works
Sangkham, S., Faikhaw, O., Munkong, N., Sakunkoo, P., Arunlertaree, C., Chavali, M., Mousazadeh, M., & Tiwari, A. (2022) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2022.113832 · Cited by 465 · see citing works
Polystyrene microplastics induced female reproductive toxicity in mice
Liu, Z., Zhuan, Q., Zhang, L., Meng, L., Fu, X., & Hou, Y. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127629 · Cited by 444 · see citing works
Feeding type and development drive the ingestion of microplastics by freshwater invertebrates
Scherer, C., Brennholt, N., Reifferscheid, G., & Wagner, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-17191-7 · Cited by 448 · see citing works
Microplastics in Livers of European Anchovies (Engraulis encrasicolus, L.)
Collard, F., Gilbert, B., Compère, P., Eppe, G., Das, K., Jauniaux, T., & Parmentier, E. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.07.089 · Cited by 438 · see citing works
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428 · see citing works
Enfrin, M., Lee, J., Gibert, Y., Basheer, F., Kong, L., & Dumée, L. F. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121393 · Cited by 410 · see citing works
Alomar, C., Sureda, A., Capó, X., Guijarro, B., Tejada, S., & Deudero, S. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.043 · Cited by 377 · see citing works
Effects of Virgin Microplastics on Goldfish (Carassius auratus)
Jabeen, K., Li, B., Chen, Q., Su, L., Wu, C., Hollert, H., & Shi, H. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.09.031 · Cited by 369 · see citing works
The fate of plastic in the ocean environment – a minireview
Wayman, C., & Niemann, H. (2021) · Environmental Science: Processes & Impacts · doi:10.1039/d0em00446d · Cited by 325 · see citing works
Grigorakis, S., Mason, S. A., & Drouillard, K. G. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2016.11.055 · Cited by 323 · see citing works
Li, Z., Zhu, S., Liu, Q., Wei, J., Jin, Y., Wang, X., & Zhang, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115025 · Cited by 301 · see citing works
McIlwraith, H. K., Kim, J., Helm, P., Bhavsar, S. P., Metzger, J. S., & Rochman, C. M. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c02922 · Cited by 295 · see citing works
Ingestion of Microplastics by Freshwater Tubifex Worms
Hurley, R. R., Woodward, J. C., & Rothwell, J. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03567 · Cited by 286 · see citing works
Jeong, C.-B., Kang, H.-M., Lee, Y. H., Kim, M.-S., Lee, J.-S., Seo, J. S., Wang, M., & Lee, J.-S. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b03211 · Cited by 263 · see citing works
Environmental fate and impacts of microplastics in aquatic ecosystems: A review
Du, S., Zhu, R., Cai, Y., Xu, N., Yap, P.-S., Zhang, Y., He, Y., & Zhang, Y. (2021) · RSC Advances · doi:10.1039/d1ra00880c · Cited by 261 · see citing works
Self-citationAli, N., Khan, M. H., Ali, M., Sidra, Ahmad, S., Khan, A., Nabi, G., Ali, F., Bououdina, M., & Kyzas, G. Z. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169489 · Cited by 262 · see citing works
Brun, N. R., van Hage, P., Hunting, E. R., Haramis, A.-P. G., Vink, S. C., Vijver, M. G., Schaaf, M. J. M., & Tudorache, C. (2019) · Communications Biology · doi:10.1038/s42003-019-0629-6 · Cited by 246 · see citing works
Negative effects of microplastic exposure on growth and development of Crepidula onyx
Lo, H. K. A., & Chan, K. Y. K. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.10.095 · Cited by 216 · see citing works
Occurrence of Microplastics in Tap and Bottled Water: Current Knowledge
Gambino, I., Bagordo, F., Grassi, T., Panico, A., & De Donno, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095283 · Cited by 213 · see citing works
Huang, J.-N., Wen, B., Xu, L., Ma, H.-C., Li, X.-X., Gao, J.-Z., & Chen, Z.-Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126830 · Cited by 202 · see citing works
Acute and chronic effects of polystyrene microplastics on juvenile and adult Daphnia magna
Eltemsah, Y. S., & Bøhn, T. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.07.087 · Cited by 195 · see citing works
Le Guen, C., Suaria, G., Sherley, R. B., Ryan, P. G., Aliani, S., Boehme, L., & Brierley, A. S. (2020) · Environment International · doi:10.1016/j.envint.2019.105303 · Cited by 192 · see citing works
Polystyrene microplastics ingestion induced behavioral effects to the cladoceran Daphnia magna
De Felice, B., Sabatini, V., Antenucci, S., Gattoni, G., Santo, N., Bacchetta, R., Ortenzi, M. A., & Parolini, M. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.05.115 · Cited by 190 · see citing works
Daniel, D. B., Ashraf, P. M., & Thomas, S. N. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115365 · Cited by 189 · see citing works
A critical review of the overlooked challenge of determining micro-bioplastics in soil
Fojt, J., David, J., Přikryl, R., Řezáčová, V., & Kučerík, J. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140975 · Cited by 165 · see citing works
Castro-Castellon, A. T., Horton, A. A., Hughes, J. M. R., Rampley, C., Jeffers, E. S., Bussi, G., & Whitehead, P. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151638 · Cited by 164 · see citing works
Chae, Y., Kim, D., Choi, M.-J., Cho, Y., & An, Y.-J. (2019) · Environment International · doi:10.1016/j.envint.2019.05.042 · Cited by 122 · see citing works
Jaikumar, G., Baas, J., Brun, N. R., Vijver, M. G., & Bosker, T. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.04.069 · Cited by 119 · see citing works
A Bayesian analysis of the factors determining microplastics ingestion in fishes
Covernton, G. A., Davies, H. L., Cox, K. D., El-Sabaawi, R., Juanes, F., Dudas, S. E., & Dower, J. F. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125405 · Cited by 108 · see citing works
Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems
Schröter, L., & Ventura, N. (2022) · Small · doi:10.1002/smll.202201680 · Cited by 99 · see citing works
Microplastic contamination in Great Lakes fish
Munno, K., Helm, P. A., Rochman, C., George, T., & Jackson, D. A. (2022) · Conservation Biology · doi:10.1111/cobi.13794 · Cited by 102 · see citing works
Mancia, A., Chenet, T., Bono, G., Geraci, M. L., Vaccaro, C., Munari, C., Mistri, M., Cavazzini, A., & Pasti, L. (2020) · Marine Environmental Research · doi:10.1016/j.marenvres.2020.104876 · Cited by 93 · see citing works
Effects of synthetic and natural microfibers on Daphnia magna—Are they dependent on microfiber type?
Kim, D., Kim, H., & An, Y.-J. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105968 · Cited by 83 · see citing works
Documentation of Microplastics in Tissues of Wild Coastal Animals
Haave, M., Gomiero, A., Schönheit, J., Nilsen, H., & Olsen, A. B. (2021) · Frontiers in Environmental Science · doi:10.3389/fenvs.2021.575058 · Cited by 80 · see citing works
Magni, S., Bonasoro, F., Della Torre, C., Parenti, C. C., Maggioni, D., & Binelli, A. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137602 · Cited by 74 · see citing works
Earn, A., Bucci, K., & Rochman, C. M. (2021) · Journal of Great Lakes Research · doi:10.1016/j.jglr.2020.11.001 · Cited by 75 · see citing works
Plastic microbeads: Small yet mighty concerning
Miraj, S. S., Parveen, N., & Zedan, H. S. (2021) · International Journal of Environmental Health Research · doi:10.1080/09603123.2019.1689233 · Cited by 73 · see citing works
Cocci, P., Gabrielli, S., Pastore, G., Minicucci, M., Mosconi, G., & Palermo, F. A. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135813 · Cited by 58 · see citing works
Is Wild Marine Biota Affected by Microplastics?
Porcino, N., Bottari, T., & Mancuso, M. (2022) · Animals · doi:10.3390/ani13010147 · Cited by 55 · see citing works
“In the laboratory, it was demonstrated that MPs can cross the intestinal barrier, travel through the bloodstream, and reach the liver [71].”
BackgroundSantana, M. F. M., Dawson, A. L., Motti, C. A., van Herwerden, L., Lefevre, C., & Kroon, F. J. (2021) · Frontiers in Environmental Science · doi:10.3389/fenvs.2021.641135 · Cited by 54 · see citing works
Are Anthropogenic Fibres a Real Problem for Red Mullets (Mullus barbatus) from the NW Mediterranean?
Rodríguez-Romeu, O., Constenla, M., Carrassón, M., Campoy-Quiles, M., & Soler-Membrives, A. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139336 · Cited by 49 · see citing works
Hoyo-Alvarez, E., Arechavala-Lopez, P., Jiménez-García, M., Solomando, A., Alomar, C., Sureda, A., Moranta, D., & Deudero, S. (2022) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.106048 · Cited by 49 · see citing works
Kim, J., Poirier, D. G., Helm, P. A., Bayoumi, M., & Rochman, C. M. (2020) · PLOS ONE · doi:10.1371/journal.pone.0239128 · Cited by 46 · see citing works
Monique, M., Giuseppe, P., Francesca, F., Davide, D. P., Savoca, S., Gioele, C., Teresa, R., Giovanni, P., Eleonora, G., Nunziacarla, S., et al. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157875 · Cited by 36 · see citing works
Yadav, D. K., Samantaray, B. P., & Kumar, R. (2024) · Science of the Total Environment · doi:10.1016/j.scitotenv.2024.174999 · Cited by 19 · see citing works
- Authors
- Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., & Ren, H.
- Affiliations
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Nanjing Normal University (CN)
- Corresponding author
- Zhang, Yan
- Ren, Hongqiang
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-03-17
- Volume
- 50
- Issue
- 7
- Pages
- 4054-4060
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2295281563
- Cited by
- 2,125
- References
- 44
- Citations by year
- 2026: 202 · 2025: 264 · 2024: 323 · 2023: 312 · 2022: 318 · 2021: 238 · 2020: 215 · 2019: 122 · 2018: 79 · 2017: 41 · 2016: 10
- FWCI
- 45.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the People's Republic of China (20130091120012)
- Ministry of Science and Technology of the People's Republic of China (2014BAC08B07)
- Natural Science Foundation of Jiangsu Province (BK20130559)
- National Natural Science Foundation of China (21407076, 21507058)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- polystyrene microplastics, zebrafish, microplastic ingestion, tissue accumulation, hepatotoxicity, oxidative stress, lipid accumulation, liver histopathology, superoxide dismutase, catalase, lipid metabolism, energy metabolism, microplastic size effects, gill, intestine
- MeSH terms
- Animals, Fluorescent Dyes, Gills, Liver, Male, Plastics, Polystyrenes, Zebrafish, Discriminant Analysis, Least-Squares Analysis, Oxidative Stress, Metabolomics, Metabolome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review