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Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status
Abstract
Human ingestion of microplastics (MPs) is inevitable due to the ubiquity of MPs in various foods and drinking water. Whether the ingestion of MPs poses a substantial risk to human health is far from understood. Here, by analyzing the characteristics of MPs in the feces of patients with inflammatory bowel disease (IBD) and healthy people, for the first time, we found that the fecal MP concentration in IBD patients (41.8 items/g dm) was significantly higher than that in healthy people (28.0 items/g dm). In total, 15 types of MPs were detected in feces, with poly(ethylene terephthalate) (22.3-34.0%) and polyamide (8.9-12.4%) being dominant, and their primary shapes were sheets and fibers, respectively. We present evidence indicating that a positive correlation exists between the concentration of fecal MPs and the severity of IBD. Combining a questionnaire survey and the characteristics of fecal MPs, we conclude that the plastic packaging of drinking water and food and dust exposure are important sources of human exposure to MPs. Furthermore, the positive correlation between fecal MPs and IBD status suggests that MP exposure may be related to the disease process or that IBD exacerbates the retention of MPs. The relative mechanisms deserve further studies. Our results also highlight that fecal MPs are useful for assessing human MP exposure and potential health risks.
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Citations
Cites
Plasticenta: First evidence of microplastics in human placenta
Ragusa, A., Svelato, A., Santacroce, C., Catalano, P., Notarstefano, V., Carnevali, O., Papa, F., Rongioletti, M. C. A., Baiocco, F., Draghi, S., et al. (2021) · Environment International · doi:10.1016/j.envint.2020.106274 · Cited by 3,474
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,117
Human Consumption of Microplastics
Cox, K. D., Covernton, G. A., Davies, H. L., Dower, J. F., Juanes, F., & Dudas, S. E. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b01517 · Cited by 2,745
Environmental exposure to microplastics: An overview on possible human health effects
Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134455 · Cited by 2,690
The global burden of IBD: from 2015 to 2025
Kaplan, G. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.150 · Cited by 2,639
Genetics and pathogenesis of inflammatory bowel disease
Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,614
Microplastics in Freshwaters and Drinking Water: Critical Review and Assessment of Data Quality
Koelmans, A. A., Mohamed Nor, N. H., Hermsen, E., Kooi, M., Mintenig, S. M., & De France, J. (2019) · Water Research · doi:10.1016/j.watres.2019.02.054 · Cited by 2,535
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es800249a · Cited by 2,263
Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., & Ren, H. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00183 · Cited by 2,125
Self-citationMicroplastics in bivalves cultured for human consumption
Van Cauwenberghe, L., & Janssen, C. R. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.06.010 · Cited by 2,074
Detection of Various Microplastics in Human Stool: A Prospective Case Series
Schwabl, P., Köppel, S., Königshofer, P., Bucsics, T., Trauner, M., Reiberger, T., & Liebmann, B. (2019) · Annals of Internal Medicine · doi:10.7326/m19-0618 · Cited by 1,951
Airborne microplastics: consequences to human health?
Prata, J. C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.043 · Cited by 1,852
A first overview of textile fibers, including microplastics, in indoor and outdoor environments
Dris, R., Gasperi, J., Mirande, C., Mandin, C., Guerrouache, M., Langlois, V., & Tassin, B. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.12.013 · Cited by 1,604
Deng, Y., Zhang, Y., Lemos, B., & Ren, H. (2017) · Scientific Reports · doi:10.1038/srep46687 · Cited by 1,471
Self-citationSchymanski, D., Goldbeck, C., Humpf, H.-U., & Fürst, P. (2018) · Water Research · doi:10.1016/j.watres.2017.11.011 · Cited by 1,410
Microplastic Pollution in Table Salts from China
Yang, D., Shi, H., Li, L., Li, J., Jabeen, K., & Kolandhasamy, P. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03163 · Cited by 1,112
Synthetic Polymer Contamination in Bottled Water
Mason, S. A., Welch, V. G., & Neratko, J. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00407 · Cited by 1,100
A review of microplastics in table salt, drinking water, and air: direct human exposure
Zhang, Q., Xu, E. G., Li, J., Chen, Q., Ma, L., Zeng, E. Y., & Shi, H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b04535 · Cited by 1,064
Lu, L., Wan, Z., Luo, T., Fu, Z., & Jin, Y. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.051 · Cited by 1,041
Qiao, R., Sheng, C., Lu, Y., Zhang, Y., Ren, H., & Lemos, B. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.01.245 · Cited by 965
Self-citationEnvironmental triggers in IBD: a review of progress and evidence
Ananthakrishnan, A. N., Bernstein, C. N., Iliopoulos, D., Macpherson, A., Neurath, M. F., Ali, R. A. R., Vavricka, S. R., & Fiocchi, C. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.136 · Cited by 948
Qiao, R., Deng, Y., Zhang, S., Wolosker, M. B., Zhu, Q., Ren, H., & Zhang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.07.065 · Cited by 920
Self-citationPolystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish
Jin, Y., Xia, J., Pan, Z., Yang, J., Wang, W., & Fu, Z. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.12.088 · Cited by 866
Oliveri Conti, G., Ferrante, M., Banni, M., Favara, C., Nicolosi, I., Cristaldi, A., Fiore, M., & Zuccarello, P. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109677 · Cited by 839
The contribution of washing processes of synthetic clothes to microplastic pollution
De Falco, F., Di Pace, E., Cocca, M., & Avella, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-43023-x · Cited by 825
Catarino, A. I., Macchia, V., Sanderson, W. G., Thompson, R. C., & Henry, T. B. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.02.069 · Cited by 780
Hernandez, E., Nowack, B., & Mitrano, D. M. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b01750 · Cited by 779
Evaluation of microplastic release caused by textile washing processes of synthetic fabrics
De Falco, F., Gullo, M. P., Gentile, G., Di Pace, E., Cocca, M., Gelabert, L., Brouta-Agnésa, M., Rovira, A., Escudero, R., Villalba, R., et al. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.10.057 · Cited by 733
Lifetime Accumulation of Microplastic in Children and Adults
Mohamed Nor, N. H., Kooi, M., Diepens, N. J., & Koelmans, A. A. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c07384 · Cited by 652
You are what you eat: Microplastics in the feces of young men living in Beijing
Zhang, N., Li, Y. B., He, H. R., Zhang, J. F., & Ma, G. S. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144345 · Cited by 519
Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease
Ananthakrishnan, A. N., Khalili, H., Konijeti, G. G., Higuchi, L. M., de Silva, P., Fuchs, C. S., Willett, W. C., Richter, J. M., & Chan, A. T. (2014) · Gut · doi:10.1136/gutjnl-2013-305304 · Cited by 516
Abundance and characteristics of microplastics in market bivalves from South Korea
Cho, Y., Shim, W. J., Jang, M., Han, G. M., & Hong, S. H. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2018.11.091 · Cited by 507
Leaching of plastic additives to marine organisms
Koelmans, A. A., Besseling, E., & Foekema, E. M. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2013.12.013 · Cited by 499
Kim, J.-S., Lee, H.-J., Kim, S.-K., & Kim, H.-J. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b04180 · Cited by 407
Microplastics generated when opening plastic packaging
Sobhani, Z., Lei, Y., Tang, Y., Wu, L., Zhang, X., Naidu, R., Megharaj, M., & Fang, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-61146-4 · Cited by 358
Microplastic contamination of packaged meat: Occurrence and associated risks
Kedzierski, M., Lechat, B., Sire, O., Le Maguer, G., Le Tilly, V., & Bruzaud, S. (2020) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2020.100489 · Cited by 352
Microplastics from consumer plastic food containers: Are we consuming it?
Fadare, O. O., Wan, B., Guo, L.-H., & Zhao, L. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126787 · Cited by 329
Micro- and nanoplastics – current state of knowledge with the focus on oral uptake and toxicity
Paul, M. B., Stock, V., Cara-Carmona, J., Lisicki, E., Shopova, S., Fessard, V., Braeuning, A., Sieg, H., & Böhmert, L. (2020) · Nanoscale Advances · doi:10.1039/d0na00539h · Cited by 277
Microplastic ingestion cause intestinal lesions in the intertidal fish Girella laevifrons
Ahrendt, C., Perez-Venegas, D. J., Urbina, M., Gonzalez, C., Echeveste, P., Aldana, M., Pulgar, J., & Galbán-Malagón, C. (2020) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2019.110795 · Cited by 231
Zarus, G. M., Muianga, C., Hunter, C. M., & Pappas, R. S. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144010 · Cited by 223
Deng, Y., Yan, Z., Shen, R., Huang, Y., Ren, H., & Zhang, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124644 · Cited by 211
Self-citationReview of synthetic human faeces and faecal sludge for sanitation and wastewater research
Penn, R., Ward, B. J., Strande, L., & Maurer, M. (2017) · Water Research · doi:10.1016/j.watres.2017.12.063 · Cited by 166
Raman microspectroscopic analysis of fibers in beverages
Wiesheu, A. C., Anger, P. M., Baumann, T., Nießner, R., & Ivleva, N. P. (2016) · Analytical Methods · doi:10.1039/c6ay01184e · Cited by 157
An efficient method for extracting microplastics from feces of different species
Yan, Z., Zhao, H., Zhao, Y., Zhu, Q., Qiao, R., Ren, H., & Zhang, Y. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121489 · Cited by 150
Self-citationCoffin, S., Huang, G., Lee, I., & Schlenk, D. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b07140 · Cited by 142
Long-Term Safety and Efficacy of Fecal Microbiota Transplant in Active Ulcerative Colitis
Ding, X. L., Li, Q., Li, P., Zhang, T., Cui, B., Ji, G., Lü, X., & Zhang, F. (2019) · Drug Safety · doi:10.1007/s40264-019-00809-2 · Cited by 139
Self-citationThe reactive oxygen species as pathogenic factors of fragmented microplastics to macrophages
Jeon, S., Lee, D.-K., Jeong, J., Yang, S. I., Kim, J.-S., Kim, J., & Cho, W. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117006 · Cited by 128
Ecotoxicological Assessment of Microplastics in Freshwater Sources—A Review
Miloloža, M., Grgić, D. K., Bolanča, T., Ukić, Š., Cvetnić, M., Bulatović, V. O., Dionysiou, D. D., & Kušić, H. (2020) · Water · doi:10.3390/w13010056 · Cited by 112
Ašmonaitė, G., Larsson, K., Undeland, I., Sturve, J., & Almroth, B. C. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b04849 · Cited by 101
Li, P., Zhang, T., Xiao, Y., Tian, L., Cui, B., Ji, G., Liu, Y., & Zhang, F. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9447-x · Cited by 93
Self-citationBeverage bottle capacity, packaging efficiency, and the potential for plastic waste reduction
Arreola, R. B., & Bucklin, R. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-82983-x · Cited by 46
Cohen, A., Pillarisetti, A., Luo, Q., Zhang, Q., Li, H., GeMei, Z., Zhu, G., Colford, J. M., Smith, K. R., Ray, I., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp7124 · Cited by 28
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The potential impact of nano- and microplastics on human health: Understanding human health risks.
Winiarska, E., Jutel, M., & Zemelka-Wiacek, M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118535 · Cited by 470
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428
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Metadata
- Authors
- Yan, Z., Liu, Y., Zhang, T., Zhang, F., Ren, H., & Zhang, Y.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-12-22
- Volume
- 56
- Issue
- 1
- Pages
- 414-421
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W4200605805
- Cited by
- 835
- References
- 53
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- closed
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