CoChat
Sign Up
Cited by 38Gut microbiota and healthNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Effects of Oat Fiber Intervention on Cognitive Behavior in LDLR–/– Mice Modeling Atherosclerosis by Targeting the Microbiome–Gut–Brain Axis

Gao, Hui, Song, Ruijuan, Li, Yuezhen, Zhang, Weiguo, Wan, Zhongxiao, Wang, Ying, Zhang, Hong, Han, Shufen·2020·Journal of Agricultural and Food Chemistry
DOI 10.1021/acs.jafc.0c05677
Open this paper in CoChat — free account

Abstract

It is known that cardiovascular disease can result in cognitive impairment. However, whether oat fiber improves cognitive behavior through a cardiovascular-related mechanism remains unclear. The present work was aimed to elucidate the potential of oat fiber on cognitive behavior by targeting the neuroinflammation signal and microbiome-gut-brain axis in a mouse model of atherosclerosis. Male low-density lipoprotein receptor knock-out (LDLR -/- ) mice were treated with a high fat/cholesterol diet without or with 0.8% oat fiber for 14 weeks. Behavioral tests indicated that LDLR -/- mice exhibited a significant cognitive impairment; however, oat fiber can improve cognitive behavior by reducing latency to the platform and increasing the number of crossing and swimming distance in the target quadrant. Oat fiber can inhibit A β plaque processing in both the cortex and hippocampus via decreasing the relative protein expression of GFAP and IBα1. Notably, oat fiber inhibited the nod-like receptor family pyrin domain-containing 3 inflammasome activation and blocked the toll-like receptor 4 signal pathway in both the cortex and hippocampus, accompanied by a reduction of circulating serum lipopolysaccharide. In addition, oat fiber raised the expressions of short-chain fatty acid (SCFA) receptors and tight junction proteins (zonula occludens-1 and occludin) and improved intestinal microbiota diversity via increasing the contents of gut metabolites SCFAs. In summary, the present study provi…

Integrity signals

Registry

Crossref · 10.1021/acs.jafc.0c05677

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Reduced SCFAs in sepsis may shift microglia toward a pro-inflammatory phenotype, worsening neural injury.

    “Reduced SCFAs in sepsis may shift microglia toward a pro-inflammatory phenotype, worsening neural injury (Gao et al., 2020; Liu et al., 2020).”

    From Progress on the correlation between sepsis and gut microbiota: a narrative review (2026) · cites this paper as Gao et al., 2020

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gao, H., Song, R., Li, Y., Zhang, W., Wan, Z., Wang, Y., Zhang, H., & Han, S.
Affiliations
  • Soochow University (CN)
  • Independent Scientist, Irving, Texas 75039, United States
  • Southeast University (CN)
Corresponding author
  • Zhang, Hong
  • Han, Shufen
ORCID
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2020-11-25
Volume
68
Issue
49
Pages
14480-14491
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/acs.jafc.0c05677
OpenAlex
W3109651320
Cited by
38
References
9
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 5
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Priority Academic Program Development of Jiangsu Higher Education Institutions
  • Chinese Nutrition Society Nutrition Research Foundation (2016097B-3)
  • Suzhou City (SYS2018022)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
oat fiber, cognitive impairment, atherosclerosis, Ldlr knockout mice, microbiome-gut-brain axis, neuroinflammation, amyloid plaques, NLRP3 inflammasome, TLR4, lipopolysaccharide, short-chain fatty acids, intestinal permeability, tight junction proteins, dietary fiber, Alzheimer's disease
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Behavior, Animal, Brain, Cognition, Dietary Fiber, Fatty Acids, Volatile, Glial Fibrillary Acidic Protein, Male, Mice, Inbred C57BL, Receptors, LDL, Mice, Knockout, Avena, Atherosclerosis, Toll-Like Receptor 4, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review