β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice
Open accessPublished version of a preprint
Abstract
Background: “Western” style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low in fiber. This diet pattern is associated with a myriad of metabolic dysfunctions, including neuroinflammation and cognitive impairment. β-glucan, the major soluble fiber in oat and barley grains, is fermented in the lower gastrointestinal tract, potentially impacting the microbial ecosystem and thus may improve elements of cognition and brain function via the gut-brain axis. The present study aimed to evaluate the effect of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD). Results: After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induced cognitive impairment assessed behaviorally by object location, novel object recognition, and nesting building tests. In the hippocampus, β-glucan countered the HFFD-induced microglia activation and its engulfment of synaptic puncta, and upregulation of proinflammatory cytokine (TNF-α, IL-1β, and IL-6) mRNA expression. Also, in the hippocampus, β-glucan significantly promoted PTP1B-IRS-pAKT-pGSK3β-pTau signaling for synaptogenesis, improved the synaptic ultrastructure examined by transmission electron microscopy, and increased both pre- and postsynaptic protein levels compared to the HFFD-treated group. In the colon, β-glucan reversed HFFD-induced gut barrier dysfunction increased the thickness of colonic mucus (Alcian blue and mucin-2 glycoprotein immunofluorescence staining), increased the levels of tight junction proteins occludin and zonula occludens-1, and attenuated bacterial endotoxin translocation. The HFFD resulted in microbiota alteration, effects abrogated by long-term β-glucan supplementation, with the β-glucan effects on Bacteroidetes and its lower taxa particularly striking. Importantly, the study of short-term β-glucan supplementation for 7 days demonstrated pronounced, rapid differentiating microbiota changes before the cognitive improvement, suggesting the possible causality of gut microbiota profile on cognition. In support, broad-spectrum antibiotic intervention abrogated β-glucan’s effects on improving cognition, highlighting the role of gut microbiota to mediate cognitive behavior. Conclusion: This study provides the first evidence that β-glucan improves indices of cognition and brain function with major beneficial effects all along the gut microbiota-brain axis. Our data suggest that elevating consumption of β-glucan-rich foods is an easily implementable nutritional strategy to alleviate detrimental features of gut-brain dysregulation and prevent neurodegenerative diseases associated with Westernized dietary patterns.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Restoring the Bacteroidetes of obese mice fed a high-fat and fiber-deficient diet through oat β-glucan supplementation restored intestinal barrier integrity, including mucus thickness and levels of tight junction proteins.
“Restoring the Bacteroidetes of obese mice fed a high-fat and fiber-deficient diet through oat β-glucan supplementation successfully restored the intestinal barrier integrity, including mucus thickness and levels of tight junction (TJ) proteins.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [644]
The beneficial effects of β-glucan on cognitive function were lost upon antibiotics administration, indicating that the gut microbiota is a vital mediator of cognitive function.
“the beneficial effects of β-glucan on cognitive function were lost upon antibiotics administration, indicating that the gut microbiota is a vital mediator of cognitive function.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [644]
β-glucan supplementation attenuated microglial activation and cognitive impairment in the obese mice.
“β-glucan supplementation attenuated microglial activation and cognitive impairment in the obese mice.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [644]
In another recent animal study, supplementation with the prebiotic beta-glucan abrogated microbiota alterations and cognitive impairment as well as microglia activation and neuroinflammation induced by a high-fat, fiber-deficient diet.
“In another recent animal study, supplementation with the prebiotic β-glucan abrogated microbiota alterations and cognitive impairment as well as microglia activation and neuroinflammation induced by a high-fat, fiber-deficient diet (321).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [321]
The microbiota composition was rescued prior to cognitive changes and the positive effects of beta-glucan were eliminated with antibiotic treatment, suggesting a potential causal relation between diet-induced microbial alterations and cognitive function.
“Importantly, the microbiota composition was rescued prior to cognitive changes and the positive effects of β-glucan were eliminated with antibiotic treatment (321), suggesting a potential causal relation between diet-induced microbial alterations and cognitive function.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [321]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 1× · see citing works
“as exemplified by synaptic engulfment and pruning [49].”
BackgroundHsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Environmental and Gut Bacteroidetes: The Food Connection
Thomas, F., Hehemann, J., Rebuffet, E., Czjzek, M., & Michel, G. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00093 · Cited by 1,329 · see citing works
The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
Spires-Jones, T. L., & Hyman, B. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.004 · Cited by 1,201 · see citing works
Assessing nest building in mice
Deacon, R. M. J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.170 · Cited by 1,115 · see citing works
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985 · see citing works
Microglia-mediated neuroinflammation in neurodegenerative diseases
Subhramanyam, C. S., Wang, C., Hu, Q., & Dheen, S. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.004 · Cited by 875 · see citing works
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Mahowald, M. A., Rey, F. E., Seedorf, H., Turnbaugh, P. J., Fulton, R. S., Wollam, A., Shah, N., Wang, C., Magrini, V. J., Wilson, R. K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901529106 · Cited by 737 · see citing works
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works
Self-citationRegulation of prefrontal cortex myelination by the microbiota
Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635 · see citing works
Kennedy, E. A., King, K. Y., & Baldridge, M. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01534 · Cited by 602 · see citing works
Zou, J., Chassaing, B., Singh, V., Pellizzon, M., Ricci, M. R., Flythe, M. D. D., Kumar, M. V., & Gewirtz, A. T. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.003 · Cited by 564 · see citing works
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works
Butt, M. S., Tahir-Nadeem, M., Khan, M. K. I., Shabir, R., & Butt, M. S. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0698-7 · Cited by 559 · see citing works
Infant gut microbiome associated with cognitive development
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H., & Knickmeyer, R. C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.021 · Cited by 541 · see citing works
Gram-negative bacterial molecules associate with Alzheimer disease pathology
Zhan, X., Stamova, B., Jin, L.-W., DeCarli, C., Phinney, B., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003391 · Cited by 521 · see citing works
SCFAs strongly stimulate PYY production in human enteroendocrine cells
Larraufie, P., Martin‐Gallausiaux, C., Lapaque, N., Dore, J. M., Gribble, F. M., Reimann, F. M., & Blottière, H. M. (2018) · Scientific Reports · doi:10.1038/s41598-017-18259-0 · Cited by 455 · see citing works
Yadav, M., & Schorey, J. S. (2006) · Blood · doi:10.1182/blood-2006-05-024406 · Cited by 422 · see citing works
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404 · see citing works
The longer-term impacts of Western diet on human cognition and the brain
Francis, H., & Stevenson, R. J. (2013) · Appetite · doi:10.1016/j.appet.2012.12.018 · Cited by 342 · see citing works
Chassaing, B., Ley, R. E., & Gewirtz, A. T. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.033 · Cited by 326 · see citing works
Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.017 · Cited by 319 · see citing works
Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders
Cheng, L.-H., Liu, Y.-W., Wu, C.-C., Wang, S. Z., & Tsai, Y.-C. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2019.01.002 · Cited by 304 · see citing works
Interplay between the gut-brain axis, obesity and cognitive function
Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00155 · Cited by 294 · see citing works
Microglia Play an Active Role in Obesity-Associated Cognitive Decline
Cope, E. C., LaMarca, E. A., Monari, P. K., Olson, L. B., Martinez, S., Zych, A. D., Katchur, N. J., & Gould, E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0789-18.2018 · Cited by 225 · see citing works
Saji, N., Niida, S., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-38218-7 · Cited by 224 · see citing works
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
Soto, M., Herzog, C., Pacheco, J. A., Fujisaka, S., Bullock, K., Clish, C. B., & Kahn, C. R. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0086-5 · Cited by 216 · see citing works
Wang, Y., Ames, N. P., Tun, H. M., Tosh, S. M., Jones, P. J. H., & Khafipour, E. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00129 · Cited by 207 · see citing works
Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology
Chen, Y., Ji, F., Guo, J., Shi, D., Fang, D., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep34055 · Cited by 205 · see citing works
Luteolin Protects against High Fat Diet-Induced Cognitive Deficits in Obesity Mice
Liu, Y., Fu, X., Lan, N., Li, S., Zhang, J., Wang, S., Li, C., Shang, Y., Huang, T., & Zhang, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.040 · Cited by 194 · see citing works
Ropelle, E. R., Pauli, J. R., Prada, P. O., de Souza, C. T., Picardi, P. K., Faria, M. C., Cintra, D. E., Fernandes, M. F. D. A., Flores, M. B. S., Velloso, L. A., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120006 · Cited by 187 · see citing works
Tamura, K., Hemsworth, G. R., Déjean, G., Rogers, T. E., Pudlo, N. A., Urs, K., Jain, N., Davies, G. J., Martens, E. C., & Brumer, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.049 · Cited by 181 · see citing works
Synaptic proteins, neuropathology and cognitive status in the oldest-old
Head, E., Corrada, M. M., Kahle-Wrobleski, K., Kim, R. C., Sarsoza, F., Goodus, M., & Kawas, C. H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.001 · Cited by 145 · see citing works
Hattiangady, B., Mishra, V., Kodali, M., Shuai, B., Rao, X., & Shetty, A. K. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00078 · Cited by 144 · see citing works
Whitfield, D., Vallortigara, J., Alghamdi, A., Howlett, D. R., Hortobágyi, T., Johnson, M., Attems, J., Newhouse, S., Ballard, C. G., Thomas, A. J., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.015 · Cited by 141 · see citing works
Relationships between dietary intake and cognitive function level in Korean elderly people
Lee, L., Kang, S., Lee, H. O., Lee, B.-H., Park, J., Kim, J.-H., Jung, I.-K., Park, Y., & Lee, J. (2001) · Public Health · doi:10.1038/sj.ph.1900729 · Cited by 138 · see citing works
Clemens, R., Kranz, S., Mobley, A. R., Nicklas, T. A., Raimondi, M. P., Rodriguez, J. C., Slavin, J. L., & Warshaw, H. S. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160176 · Cited by 123 · see citing works
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?
Vieira, M. N. N., Silva, N. M. L. E., Ferreira, S. T., & Felice, F. G. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00007 · Cited by 122 · see citing works
Dietary Fiber Is Positively Associated with Cognitive Control among Prepubertal Children ,
Khan, N. A., Raine, L. B., Drollette, E. S., Scudder, M. R., Kramer, A. F., & Hillman, C. H. (2014) · Journal of Nutrition · doi:10.3945/jn.114.198457 · Cited by 117 · see citing works
Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice
Zhou, X., Zhang, F., Hu, X., Chen, J., Wen, X., Sun, Y., Liu, Y., Tang, R., Zheng, K., & Song, Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.015 · Cited by 94 · see citing works
Self-citationObesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1
Heyward, F. D., Gilliam, D., Coleman, M. A., Gavin, C. F., Wang, J., Kaas, G. A., Trieu, R. J., Lewis, J., Moulden, J., & Sweatt, J. D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1934-15.2016 · Cited by 94 · see citing works
The impact of dietary energy intake on cognitive aging
Mattson, M. P. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.005.2010 · Cited by 91 · see citing works
Zhang, P., Yu, Y., Qin, Y., Zhou, Y., Tang, R., Wang, Q., Li, X., Wang, H., Weston–Green, K., Huang, X., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.016 · Cited by 91 · see citing works
Self-citationKang, S., Kim, C. H., Jung, H., Kim, E., Song, H., & Lee, J. E. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.029 · Cited by 89 · see citing works
Beck, E. J., Tapsell, L. C., Batterham, M. J., Tosh, S. M., & Huang, X. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.09.012 · Cited by 84 · see citing works
Self-citationKarumuthil‐Melethil, S., Gudi, R. R., Johnson, B. M., Perez, N., & Vasu, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400186 · Cited by 80 · see citing works
Wang, H., Sun, X., Zhang, N., Ji, Z., Ma, Z., Fu, Q., Qu, R., & Ma, S. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.001 · Cited by 78 · see citing works
Jiang, Y., Liu, Y., Zhu, C., Ma, X., Ma, L., Zhou, L., Huang, Q., Lei, C., Pi, R., & Chen, X. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.003 · Cited by 76 · see citing works
Role of microtubule-associated protein tau phosphorylation in Alzheimer’s disease
Ma, R.-H., Zhang, Y., Hong, X.-Y., Zhang, J., Wang, J., & Liu, G. (2017) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-017-1732-x · Cited by 66 · see citing works
Camer, D., Yu, Y., Szabo, A., Fernandez, F., Dinh, C. H. L., & Huang, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.004 · Cited by 61 · see citing works
Self-citationProtein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
Fuentes, F., Zimmer, D. J., Atienza, M., Schottenfeld, J., Penkala, I. J., Bale, T. L., Bence, K. K., & Arregui, C. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041536 · Cited by 60 · see citing works
Huang, X., Yu, Y., Beck, E. J., South, T., Li, Y., Batterham, M. J., Tapsell, L. C., & Chen, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100095 · Cited by 58 · see citing works
Self-citationWang, S., Huang, X., Zhang, P., Newell, K. A., Wang, H., Zheng, K., & Yu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-12156-2 · Cited by 53 · see citing works
Self-citationXu, N., Fan, W., Zhou, X., Liu, Y., Ma, P., Qi, S., & Gu, B. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0269-4 · Cited by 53 · see citing works
Trends in dietary fiber intake in Chinese aged 45 years and above, 1991–2011
Wang, H. J., Wang, Z. H., Zhang, J. G., Du, W., Su, C., Zhang, J., Zhai, F., & Zhang, B. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.24 · Cited by 49 · see citing works
Neuron‐microglia interaction induced bi‐directional cytotoxicity associated with calpain activation
Podbielska, M., Das, A., Smith, A. W., Chauhan, A., Ray, S. K., Inoue, J., Azuma, M., Nozaki, K., Hogan, E. L., & Banik, N. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13774 · Cited by 47 · see citing works
Zhou, X., Wang, S., Ding, X., Li, Q., Mao, Y., Chen, L., Li, W., & Ying, C. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.06.001 · Cited by 45 · see citing works
Self-citationMechanism of macrophage activation induced by β-glucan produced from Paenibacillus polymyxa JB115
Chang, Z., Lee, J., Gebru, E., Hong, J., Jung, H.-K., Jo, W.-S., & Park, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.064 · Cited by 38 · see citing works
Hynönen, U., Rasinkangas, P., Satokari, R. M., Paulin, L. G., de Vos, W. M., Pietilä, T. E., Kant, R., & Palva, A. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.03.001 · Cited by 34 · see citing works
Camer, D., Yu, Y., Szabo, A., Dinh, C. H. L., Wang, H., Cheng, L., & Huang, X. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.018 · Cited by 34 · see citing works
Self-citationPathak, N. M., Pathak, V., Lynch, A. M., Irwin, N., Gault, V. A., & Flatt, P. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.035 · Cited by 29 · see citing works
Temporal order memory differences in Alzheimer's disease and vascular dementia
Hampstead, B. M., Libon, D., Moelter, S., Swirsky-Sacchetti, T., Scheffer, L., Platek, S., & Chute, D. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390903418918 · Cited by 23 · see citing works
The effect of dietary fat on behavior in mice
Keleher, M. R., Zaidi, R., Patel, K., Ahmed, A. A. B., Bettler, C., Pavlatos, C., Shah, S., & Cheverud, J. M. (2018) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-018-0373-3 · Cited by 19 · see citing works
Is Dietary Fiber Considered an Essential Nutrient?
Kohn, J. B. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.12.004 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [61]Huang XF Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice Mol Nutr Food Res 2011 55 7 1118 1121 10.1002/mnfr.201100095 21688388 · DOI
- [67]Paxinos G Franklin KBJ The mouse brain in stereotaxic coordinates, 1st edn 2002 San Diego Academic Press
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Pediatric obesity—Long‐term consequences and effect of weight loss
Marcus, C., Danielsson, P., & Hagman, E. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13547 · Cited by 267 · see citing works
Highland barley: Chemical composition, bioactive compounds, health effects, and applications
Obadi, M., Sun, J. S., & Xu, B. (2021) · Food Research International · doi:10.1016/j.foodres.2020.110065 · Cited by 253 · see citing works
Hao, W., Ma, Q., Wang, L., Yuan, N., Gan, H. T., He, L., Li, X., Huang, J., & Chen, J. (2024) · Microbiome · doi:10.1186/s40168-024-01756-6 · Cited by 149 · see citing works
Zhao, C., Hu, X., Bao, L., Wu, K., Zhao, Y., Xiang, K., Li, S., Wang, Y., Qiu, M., Feng, L., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01402-z · Cited by 135 · see citing works
Naomi, R., Teoh, S. H., Embong, H., Balan, S. S., Othman, F., Bahari, H., & Yazid, M. D. (2023) · Antioxidants · doi:10.3390/antiox12051071 · Cited by 121 · see citing works
Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 118 · see citing works
Pan, W., Zhao, J., Wu, J., Xu, D., Meng, X., Jiang, P., Shi, H., Ge, X., Yang, X., Hu, M., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01471-8 · Cited by 113 · see citing works
Self-citationZhang, H., Jiang, F., Zhang, J., Wang, W., Li, L., & Yan, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.166 · Cited by 112 · see citing works
Yang, L., Wang, Y., Li, Z., Wu, X., Mei, J., & Zheng, G. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120714 · Cited by 106 · see citing works
Zheng, M., Ye, H., Yang, X., Shen, L., Dang, X., Liu, X., Gong, Y., Wu, Q., Wang, L., Ge, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.016 · Cited by 89 · see citing works
Self-citationZhang, Y., Li, Y., Lu, P., Dai, G.-C., Chen, X.-X., & Rui, Y. (2021) · Food & Function · doi:10.1039/d0fo03468a · Cited by 88 · see citing works
Mo, X., Sun, Y., Liang, X., Li, L., Hu, S., Xu, Z., Liu, S., Zhang, Y., Li, X., & Liu, L. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.119046 · Cited by 77 · see citing works
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 83 · see citing works
Pak, S., Chen, F., Ma, L., Hu, X., & Ji, J. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.05.013 · Cited by 70 · see citing works
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 68 · see citing works
Zheng, M., Yang, X., Wu, Q., Gong, Y., Pang, N., Ge, X., Nagaratnam, N., Jiang, P., Zhou, M., Hu, T., et al. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200597 · Cited by 64 · see citing works
Self-citationBioactive Components and Health Functions of Oat
Tang, Y., Li, S., Yan, J., Peng, Y., Weng, W., Yao, X., Gao, A., Cheng, J., Ruan, J., & Xu, B. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2029477 · Cited by 64 · see citing works
Lan, Y., Ma, Z., Chang, L., Peng, J., Zhang, M., Sun, Q., Qiao, R., Hou, X., Ding, X., Zhang, Q., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123797 · Cited by 62 · see citing works
Zhang, Q., Jin, K., Chen, B., Liu, R., Cheng, S., Zhang, Y., & Lü, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.884579 · Cited by 60 · see citing works
Koblinsky, N. D., Power, K. A., Middleton, L. E., Ferland, G., & Anderson, N. D. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac166 · Cited by 62 · see citing works
Lian, Z., Xu, Y., Wang, C., Chen, Y., Li, Y., Liu, Z., Liu, Y., He, P., Cai, Z., & Zhao, J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106714 · Cited by 60 · see citing works
Sun, D., Huang, Y., Wang, Z., Tang, X., Ye, W., Cao, H., & Shen, H. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169704 · Cited by 57 · see citing works
Zhang, X., Zhang, Y., He, Y., Zhu, X., Ai, Q., & Shi, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-022-03866-x · Cited by 54 · see citing works
Jin, X., Liu, Y., Wang, J., Wang, X., Tang, B., Liu, M., & Liu, X. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118719 · Cited by 52 · see citing works
Biopharmaceutical applications of microbial polysaccharides as materials: A Review
Song, Y., Li, S., Hao, G., Yip, R. C. S., & Chen, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124259 · Cited by 51 · see citing works
Dietary fiber and polyphenols from whole grains: effects on the gut and health improvements
Wei, X., Wang, J., Wang, Y., Zhao, Y., Long, Y., Tan, B., Li, Q. X., Dong, Z., & Wan, X. (2024) · Food & Function · doi:10.1039/d4fo00715h · Cited by 51 · see citing works
Self-citationPan, S., Wei, H., Yuan, S., Kong, Y., Yang, H., Zhang, Y., Cui, X., Chen, W., Liu, J., & Zhang, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1022879 · Cited by 51 · see citing works
Bai, Y., Zhou, X., Li, N., Zhao, J., Ye, H., Zhang, S., Yang, H., Pi, Y., Tao, S., Han, D., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9051071 · Cited by 49 · see citing works
Zhang, Y., Pan, H., Ye, X., & Chen, S. (2022) · Food & Function · doi:10.1039/d1fo04147a · Cited by 48 · see citing works
Yuan, M., Chang, L., Gao, P., Li, J., Xin-yuan, L., Hua, M., Li, X., Liu, X., & Lan, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133794 · Cited by 50 · see citing works
Song, Y., Deng, Q., Li, J., Chen, R., Li, D., Wang, S., Jing, B., & Zhou, X. Y. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123960 · Cited by 47 · see citing works
Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells
Xu, Y., Bai, T., Xiong, Y., Liu, C., Liu, Y., Hou, X., & Song, J. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15596 · Cited by 44 · see citing works
Three Different Types of β-Glucans Enhance Cognition: The Role of the Gut-Brain Axis
Hu, M., Zhang, P., Wang, R. L., Zhou, M., Pang, N., Cui, X., Ge, X., Liu, X., Huang, X., & Yu, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.848930 · Cited by 48 · see citing works
Self-citationLi, B., Ding, M., Liu, X., Zhao, J., Ross, R. P., Stanton, C., Yang, B. K., & Chen, W. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04602 · Cited by 43 · see citing works
Pirozzi, C., Coretti, L., Opallo, N., Bové, M., Annunziata, C., Comella, F., Turco, L., Lama, A., Trabace, L., Meli, R., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1143004 · Cited by 42 · see citing works
Gong, J., Su, Y., Lei, J., Zhu, S., He, Y., Tan, C. P., Liu, Y., & Xu, Y. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.109778 · Cited by 42 · see citing works
Zhang, Q., Zhao, W., Hou, Y., Song, X., Yu, H., Tan, J., Zhou, Y., & Zhang, H. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14132 · Cited by 40 · see citing works
Effects of chronic triclosan exposure on social behaviors in adult mice
Hao, Y., Li, M. C., Zhang, Y., Chen, A., Zhao, Y., Lian, K., Guo, X., Wang, X., Du, Y., Wang, X., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127562 · Cited by 41 · see citing works
Self-citationXiao, W., Li, J.-Y., Gao, X., Yang, H., Su, J.-B., Weng, R.-Y., Gao, Y.-Q., Ni, W., & Gu, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114225 · Cited by 35 · see citing works
Designing healthier bread through the lens of the gut microbiota
Wang, Y., Jian, C., Salonen, A., Dong, M., & Yang, Z. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.02.007 · Cited by 38 · see citing works
Wu, J., Zhu, Y., Zhou, L., Yang, L., Feng, T., Dai, M., Liu, J., Xu, W., Cheng, W., Sun, F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.710513 · Cited by 36 · see citing works
Self-citationZhang, Y., Wang, G., Li, R., Liu, R., Yu, Z., Zhang, Z., & Wan, Z. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2022.105459 · Cited by 37 · see citing works
Yu, L., Gao, Y., Ye, Z., Duan, H., Zhao, J., Zhang, H., Narbad, A., Tian, F., Zhai, Q., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2217727 · Cited by 39 · see citing works
Bai, J., Li, Y., Zhang, W., Fan, M., Qian, H., Zhang, H., Qi, X., & Wang, L. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101010 · Cited by 38 · see citing works
Gao, H., Song, R., Li, Y., Zhang, W., Wan, Z., Wang, Y., Zhang, H., & Han, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05677 · Cited by 38 · see citing works
Xu, Y., Xiong, Y., Liu, Y., Li, G., Bai, T., Zheng, G., Hou, X., & Song, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-00952-5 · Cited by 36 · see citing works
Bi, T., Feng, R., Zhan, L., Ren, W., & Lu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651517 · Cited by 36 · see citing works
Akkermansia muciniphila ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model
Guo, D., Park, C., Li, Y., Li, B., Yang, Q., Deng, Y., Gao, N., Li, R., Wang, X., Yi, L., et al. (2022) · Food & Function · doi:10.1039/d2fo01478e · Cited by 35 · see citing works
Fermented dairy foods consumption and depressive symptoms: A meta-analysis of cohort studies
Luo, Y., Li, Z., Gu, L., & Zhang, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281346 · Cited by 35 · see citing works
Huang, R., Liu, P., Bai, Y., Huang, J., Pan, R., Li, H., Su, Y., Zhou, Q., Ma, R., Zong, S., et al. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200344 · Cited by 35 · see citing works
Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration
Zeng, J., Cheong, L. Y. T., & Lo, C. H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1456948 · Cited by 35 · see citing works
Raghavan, K., Dedeepiya, V. D., Ikewaki, N., Sonoda, T., Iwasaki, M., Preethy, S., & Abraham, S. J. (2022) · BMJ Neurology Open · doi:10.1136/bmjno-2021-000203 · Cited by 34 · see citing works
Hao, Z., Ji, R., Su, Y., Wang, H., Yang, W., Zhang, S., Liu, Y., Ma, S., Guan, F., & Cui, Y. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c08548 · Cited by 33 · see citing works
Li, S., Chen, Y., Zhang, Y., Lv, H., Luo, L., Wang, S., & Guan, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02079 · Cited by 33 · see citing works
Ji, C., Guo, P., Han, M., Chen, K., Qin, J., & Yang, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7807 · Cited by 33 · see citing works
Mejía-Caballero, A., Salas-Villagrán, V. A., Jiménez-Serna, A., & Farrés, A. (2021) · Journal of Industrial Microbiology & Biotechnology · doi:10.1093/jimb/kuab052 · Cited by 32 · see citing works
Ran, Z., Ju, B., Cao, L., Hou, Q., Wen, L., Geng, R., Liao, Y., Hu, J., & Yang, J. (2023) · Food & Function · doi:10.1039/d2fo03110h · Cited by 32 · see citing works
Ding, H., Reiss, A. B., Pinkhasov, A., & Kasselman, L. J. (2022) · Medicina · doi:10.3390/medicina58081025 · Cited by 32 · see citing works
Mio, K., Otake, N., Nakashima, S., Matsuoka, T., & Aoe, S. (2021) · Nutrients · doi:10.3390/nu13030907 · Cited by 31 · see citing works
Jiang, Y., Wang, Z., Wang, W., Liu, Y., Meng, Y., Wang, Y., Fan, M., & Cai, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119065 · Cited by 30 · see citing works
Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities
Liu, Y., Wu, L., Peng, W., & Mao, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102638 · Cited by 31 · see citing works
A critical review on the impacts of β-glucans on gut microbiota and human health
Edo, G. I., Mafe, A. N., Ali, A. B. M., Akpoghelie, P. O., Yousif, E. A., Isoje, E. F., Igbuku, U. A., Zainulabdeen, K., Owheruo, J. O., Essaghah, A. E. A., et al. (2025) · The Microbe · doi:10.1016/j.microb.2025.100394 · Cited by 30 · see citing works
β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota
Wang, X., Qu, Y., Wang, Y., Wang, X., Xu, J., Zhao, H., Zheng, D., Sun, L., Tai, G., Zhou, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859923 · Cited by 31 · see citing works
Marcos, J. L., Olivares-Barraza, R., Ceballo, K., Wastavino, M., Ortiz, V., Riquelme, J., Martínez-Pinto, J., Muñoz, P., Cruz, G., & Sotomayor‐Zárate, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021468 · Cited by 29 · see citing works
Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
Cai, Y., Liu, P., Zhou, X., Yuan, J., & Chen, Q. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1178399 · Cited by 29 · see citing works
Wang, X.-H., Xu, D., Chen, Y., Yue, S., Fu, R., Huang, L. J., & Tang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.952938 · Cited by 28 · see citing works
Hu, R., Yang, T., Ai, Q., Shi, Y., Ji, Y.-C., Sun, Q., Tong, B., Chen, J., & Wang, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04991-5 · Cited by 27 · see citing works
Zhu, L., Zhang, Z., Luo, T. F., Li, H., Deng, Z., Li, J., Zheng, L., Liao, J., Wang, M., & Zhang, B. (2025) · Microbiome · doi:10.1186/s40168-025-02094-x · Cited by 26 · see citing works
Interaction between β-glucans and gut microbiota: a comprehensive review
Karimi, R., Homayoonfal, M., Malekjani, N., Kharazmi, M. S., & Jafari, S. M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2192281 · Cited by 28 · see citing works
Marcobal, A. M., McConnell, B., Drexler, R. A., Ng, K. M., Maldonado-Gómez, M. X., Conner, A. M. S., Vierra, C. G., Krishnakumar, N., Gerber, H., Garcia, J. K. A., et al. (2024) · Nutrients · doi:10.3390/nu16142240 · Cited by 25 · see citing works
The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota
Ren, G., Fan, X. M., Teng, C., Li, Y., Everaert, N., & Blecker, C. S. (2021) · Foods · doi:10.3390/foods10112891 · Cited by 27 · see citing works
Microbiome in drug resistance to colon cancer
Pandey, K. R., & Umar, S. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100472 · Cited by 24 · see citing works
Ji, J., Yi, X., Zhu, Y., Yu, H., Huang, S., Liu, Z., Zhang, X., Xia, G., & Shen, X. (2021) · Foods · doi:10.3390/foods10123129 · Cited by 24 · see citing works
Chen, B., Zhao, C., Zhu, H., Lu, X., Liu, H., Lu, Q., Zhu, T., & Huang, C. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176161 · Cited by 23 · see citing works
Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization
Wang, Q., Song, Y.-X., Wu, X., Luo, Y.-G., Miao, R., Yu, X.-M., Guo, X., Wu, D.-Z., Bao, R., Mi, W., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.02.083 · Cited by 24 · see citing works
Self-citationCoarse cereals modulating chronic low-grade inflammation: review
Zhang, Y., Çapanoğlu, E., Jiao, L., Yin, L., Liu, X., Wang, R., Xiao, J., & Lu, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2070596 · Cited by 23 · see citing works
Wiefels, M. D., Furar, E., Eshraghi, R. S., Mittal, J., Memis, I., Moosa, M., Mittal, R., & Eshraghi, A. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666221003085508 · Cited by 24 · see citing works
Jian, Y., Cheng, L., Hong, Y., Li, Z., Li, C., Ban, X., Zhu, L., & Gu, Z. (2023) · Nutrients · doi:10.3390/nu15245080 · Cited by 23 · see citing works
Zhang, S. Q., Wang, X., Liu, S., Hu, C. Y., & Meng, Y. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.008 · Cited by 24 · see citing works
Dai, M., Yang, X., Yu, Y., & Pan, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827486 · Cited by 23 · see citing works
Self-citationLiu, X., Li, M., Jian, C., Wei, F., Liu, H., Li, K., & Qin, X. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0039 · Cited by 22 · see citing works
Wang, J., Chen, J., Li, L., Zhang, H., Pang, D., Ouyang, H., Jin, X., & Tang, X. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02524-22 · Cited by 23 · see citing works
Yang, X., Zhou, Y., Tan, S., Tian, X., Meng, X., Li, Y., Zhou, B., Zhao, G., Ge, X., He, C., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.008 · Cited by 22 · see citing works
Self-citationZhou, K., Peng, M., Deng, N., Tan, Z., & Xiao, N. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02647-2 · Cited by 21 · see citing works
Ta, X., Wang, B., Bai, J., Yu, J., Chen, H., & Wang, C. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140791 · Cited by 21 · see citing works
Mechanistic insights into β-glucans and gut microbiota interactions for enhancing human health
Edo, G. I., Mafe, A. N., Ali, A. B. M., Akpoghelie, P. O., Yousif, E. A., Isoje, E. F., Igbuku, U. A., Zainulabdeen, K., Owheruo, J. O., Essaghah, A. E. A., et al. (2025) · Discover Food · doi:10.1007/s44187-025-00503-6 · Cited by 19 · see citing works
Dietary fiber intake is positively related with cognitive function in US older adults
Sun, W., Li, S., Chen, C., Lu, Z., & Zhang, D. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104986 · Cited by 19 · see citing works
Raghavan, K., Dedeepiya, V. D., Kandaswamy, R. S., Mangaleswaran, B., Ikewaki, N., Sonoda, T., Kurosawa, G., Iwasaki, M., Preethy, S., & Abraham, S. J. (2022) · Brain and Behavior · doi:10.1002/brb3.2750 · Cited by 19 · see citing works
Wan, J., Ma, L., Jiao, X., Dong, W., Lin, J.-T., Qiu, Y., Wu, W.-F., Liu, Q., Chen, C., Huang, H., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14604 · Cited by 20 · see citing works
Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases
Nie, T., Li, Y., Tang, F., Duan, Y., Nepovimová, E., Kuča, K., Wu, Q., & Wei, W. (2024) · Current Neuropharmacology · doi:10.2174/1570159x23666241101093436 · Cited by 19 · see citing works
Jiang, Y., Zhou, T., Zhang, S., Leng, J., Li, L., & Zhao, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140846 · Cited by 19 · see citing works
Liu, Y., Liu, Q., Wang, H., Qiu, Y., Lin, J.-T., Wu, W.-F., Wang, N., Dong, W., Wan, J., Chen, C., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14410 · Cited by 18 · see citing works
Wang, Y., Rong, X., Guan, H., Ouyang, F., Zhou, X., Li, F., Tan, X., & Li, D. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200767 · Cited by 18 · see citing works
Wei, F., Jiang, H.-B., Zhu, C., Zhong, L., Lin, Z., Yan, W., & Song, L. (2024) · Food & Function · doi:10.1039/d4fo02704c · Cited by 18 · see citing works
Jin, X., Liu, Y., Vallée, I., Karadjian, G., Liu, M., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.926765 · Cited by 17 · see citing works
Wang, Q., Guo, X., Yue, Q., Zhu, S., Guo, L., Li, G., Zhou, Q., Xiang, Y., Chen, G., Yin, W., et al. (2022) · The Anatomical Record · doi:10.1002/ar.25055 · Cited by 17 · see citing works
Self-citationADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
Bi, Z., Chen, J., Chang, X., Li, D., Yao, Y., Cai, F., Xu, H., Cheng, J. G., Hua, Z., & Zhuang, H. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-0990-1 · Cited by 17 · see citing works
Ren, J., Zhang, Y., Pan, H., Shi, R., Zhu, H., Yang, R., Zhang, L., Chen, B., Zhu, T., Lu, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111405 · Cited by 18 · see citing works
- Authors
- Shi, H., Yu, Y., Lin, D., Zheng, P., Zhang, P., Hu, M., Wang, Q., Pan, W., Yang, X., Hu, T., Li, Q., Tang, R., Zhou, F., Zheng, K., & Huang, X.-F.
- Affiliations
- Xuzhou Medical College (CN)
- University of Wollongong (AU)
- Corresponding author
- Yu, Yinghua
- Zheng, Kuiyang
- Huang, Xu-Feng
- ORCID
- Venue
- Microbiome
- Published
- 2020-10-02
- Volume
- 8
- Issue
- 1
- Pages
- 143-143
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC7532656
- OpenAlex
- W3090508437
- Cited by
- 264
- References
- 74
- Citations by year
- 2026: 23 · 2025: 56 · 2024: 64 · 2023: 43 · 2022: 53 · 2021: 22 · 2020: 2
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion)
- Funders
- National Natural Science Foundation of China (National Natural Science Foundation of China)
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China (19KJA560003)
- the Starting Foundation for Talents of Xuzhou Medical University (D2018003)
- the Priority Academic Program Development of Jiangsu Higher Education Institutions ((PAPD) in 2014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- gut-brain axis, cognitive impairment, diet-induced obesity, gut microbiota, hippocampus, neuroinflammation, microglial activation, synaptic ultrastructure, tau phosphorylation, intestinal barrier dysfunction, colonic mucus, tight junctions, endotoxin translocation, Bacteroidetes, dietary fiber supplementation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Dietary Fiber, Male, Mice, Inbred C57BL, Obesity, beta-Glucans, Mice, Diet, High-Fat, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
