Mangiferin: Sources, Anti-Inflammatory Activities, and Molecular Mechanisms
Abstract
Mangiferin, an abundant natural compound in mangoes, has demonstrated notable anti-inflammatory properties across diverse disease models. This review critically examines the recent advancements (primarily post-2020) in elucidating the molecular action mechanisms of mangiferin, emphasizing its role in modulating key signaling pathways such as NF-κB, NLRP3, AMPK, and Nrf2. Its therapeutic potential encompasses a wide range of inflammation-related disorders, including those affecting the bowel, liver, lung, kidney, brain, and cardiovascular system. Additionally, the review addresses the natural and synthetic production of mangiferin, its synergistic effects in combination therapies, strategies for enhancing its bioavailability, and in silico-based predictive analyses. While preclinical data affirm its safety, we identified key gaps for clinical translation: sustainable production, bioavailability optimization, and validation in human trials. This work underscores the unique potential of mangiferin as a next-generation anti-inflammatory therapeutic agent.
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Safety reporting is inconsistent, with limited long-term toxicity, immunomodulatory risk, and drug-drug interaction data.
“Furthermore, safety reporting is inconsistent, with limited long-term toxicity, immunomodulatory risk and drug-drug interaction data, and with few studies that stratify patients by sex or age (184,185,190).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [184]
Human evidence remains sparse, with a lack of standardized endpoints, validated translational biomarkers, and prospective trials incorporating randomization, blinding, and predefined primary outcomes.
“Human evidence remains sparse, with a lack of standardized endpoints, validated translational biomarkers, and prospective trials that incorporate randomization, blinding and predefined primary outcomes (184,191).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [184]
Standardized laboratory safety assessments and histopathology are incompletely reported in many efficacy-focused studies.
“iii) incomplete reporting of standardized laboratory safety assessments and histopathology in a number of efficacy-focused studies (184).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [184]
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Inflammation: Is It a Healer, Confounder, or a Promoter of Cardiometabolic Risks?
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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
“Furthermore, safety reporting is inconsistent, with limited long‑term toxicity, immunomodulatory risk and drug‑drug interaction data, and with few studies that stratify patients by sex or age (184,185,190).”
Influential
- Authors
- Shang, Y., Tian, J., Zhang, Z., Luo, L., Saeheng, S., Qiu, S., Zhou, R., Chen, J., & Li, L.
- Affiliations
- Panzhihua University (CN)
- Prince of Songkla University (TH)
- Corresponding author
- Tian, Jinfeng
- ORCID
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2025-10-18
- Volume
- 73
- Issue
- 43
- Pages
- 27145-27160
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4415313882
- Cited by
- 12
- References
- 8
- Citations by year
- 2026: 12
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Technology Department of Sichuan Province (2025YFHZ0155)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- mangiferin, mango, anti-inflammatory activity, NF-κB signaling, NLRP3 inflammasome, AMPK signaling, Nrf2 signaling, inflammation-related diseases, bioavailability enhancement, combination therapy, in silico prediction, clinical translation
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Anti-Inflammatory Agents, Humans, Inflammation, Plant Extracts, Signal Transduction, NF-kappa B, Mangifera, Xanthones, NF-E2-Related Factor 2
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