Cited by 56Computational Drug Discovery MethodsPharmaceutical studies and practicesPharmaceutical Economics and Policy

A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine

Scott, Kevin A., Qureshi, M. Haziq, Cox, Philip B., Marshall, Christopher M., Bellaire, Bailey C., Wilcox, Michael, Stuart, Bradey A. R., Njardarson, Jon T.·2020·Journal of Medicinal Chemistry

Abstract

The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.

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Crossref · 10.1021/acs.jmedchem.0c01502

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Authors
Scott, K. A., Qureshi, M. H., Cox, P. B., Marshall, C. M., Bellaire, B. C., Wilcox, M., Stuart, B. A. R., & Njardarson, J. T.
Affiliations
  • University of Arizona (US)
  • AbbVie (United States) (US)
  • Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States
Venue
Journal of Medicinal Chemistry
Published
2020-10-30
Volume
63
Issue
24
Pages
15449-15482
ISSN
  • 0022-2623 (ISSN-L)
  • 1520-4804
OpenAlex
W3096653525
Cited by
56
References
140
Citations by year
2026: 11 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 13 · 2021: 5
FWCI
3.36
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Division of Chemistry (CHE 1855708)
Topics
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Keywords
veterinary therapeutics, drug approval, molecular structure, physicochemical properties, drug metabolism, pharmacokinetics, oral bioavailability, structure-function relationship, biologics, combination drugs, drug repurposing
MeSH terms
Anesthetics, Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Antifungal Agents, Antiparasitic Agents, Cytochrome P-450 Enzyme System, Humans, Insecticides, United States, United States Food and Drug Administration, Drug Approval, Veterinary Drugs, Small Molecule Libraries

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