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Cited by 17

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors

Yoon, Suyoung, Kim, Jong Hyun, Kim, Sung-Eun, Kim, Changhoon, Tran, Phuong-Thao, Ann, Jihyae, Koh, Yura, Jang, Jayun, Kim, Sungmin, Moon, Hee-sun, Kim, Won Kyung, Lee, Sangkook, Lee, Jiyoun, Kim, Sunghoon, Lee, Jeewoo·2016·Journal of Medicinal Chemistry
DOI 10.1021/acs.jmedchem.6b01190
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Abstract

Recent studies indicate that LRS may act as a leucine sensor for the mTORC1 pathway, potentially providing an alternative strategy to overcome rapamycin resistance in cancer treatments. In this study, we developed leucyladenylate sulfamate derivatives as LRS-targeted mTORC1 inhibitors. Compound 18 selectively inhibited LRS-mediated mTORC1 activation and exerted specific cytotoxicity against colon cancer cells with a hyperactive mTORC1, suggesting that 18 may offer a novel treatment option for human colorectal cancer.

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Crossref · 10.1021/acs.jmedchem.6b01190

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Citations

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Research works printed but not linked: 37

  1. 10.1016/j.cell.2012.03.017 · DOI · Paper page
  2. 10.1038/nrm2672 · DOI · Paper page
  3. 10.1126/science.1187532 · DOI
  4. 10.1016/j.ccr.2010.01.021 · DOI · Paper page
  5. 10.1038/nrm3025 · DOI · Paper page
  6. 10.1016/j.tips.2014.11.004 · DOI
  7. 10.1056/NEJMoa066838 · DOI
  8. 10.1016/S0140-6736(08)61039-9 · DOI · Paper page
  9. 10.1200/JCO.2012.45.5766 · DOI · Paper page
  10. 10.1586/17512433.2013.827397 · DOI
  11. 10.4161/auto.5.5.8504 · DOI
  12. 10.1111/j.1753-4887.2007.tb00289.x · DOI
  13. 10.1152/ajpendo.00525.2011 · DOI
  14. 10.1016/j.cell.2012.02.044 · DOI · Paper page
  15. 10.1016/j.molcel.2012.02.009 · DOI
  16. 10.1002/emmm.201100626 · DOI
  17. 10.1021/acschembio.5b00291 · DOI
  18. 10.1128/AAC.01339-16 · DOI
  19. 10.1128/AAC.00820-16 · DOI
  20. 10.1073/pnas.0802862105 · DOI
  21. 10.1038/nchembio.1381 · DOI
  22. 10.1039/C5OB00791G · DOI
  23. 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I · DOI
  24. 10.1074/jbc.M803348200 · DOI
  25. 10.1016/j.bmcl.2016.05.011 · DOI · Paper page
  26. 10.1016/j.bmc.2004.09.055 · DOI
  27. 10.1016/S0960-894X(00)00360-7 · DOI
  28. 10.1016/S0960-894X(03)00020-9 · DOI
  29. 10.1016/j.bmcl.2005.05.035 · DOI
  30. 10.1016/j.ejmech.2015.02.010 · DOI
  31. 10.1021/ml2000615 · DOI
  32. 10.1016/S0040-4039(98)00888-0 · DOI
  33. 10.1093/nar/gkm169 · DOI
  34. 10.1038/nprot.2006.179 · DOI
  35. 10.3748/wjg.v20.i15.4178 · DOI
  36. 10.18632/oncotarget.1548 · DOI
  37. 10.1002/ejoc.201300699 · DOI

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Metadata

Authors
Yoon, S., Kim, J. H., Kim, S.-E., Kim, C., Tran, P.-T., Ann, J., Koh, Y., Jang, J., Kim, S., Moon, H.-S., Kim, W. K., Lee, S., Lee, J., Kim, S., & Lee, J.
Affiliations
  • Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
  • Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
  • Department of Global Medical Science, Sungshin University, Seoul 142-732, Korea
Venue
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Published
2016-11-09
Volume
59
Issue
22
Pages
10322-10328
ISSN
  • 0022-2623
  • 1520-4804
DOI
10.1021/acs.jmedchem.6b01190
Cited by
17
References
1
Language
en
Funders
National Research Foundation of Korea (NRF-2012M3A6A4054928)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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