Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

Ren, Yan; Su, Yaning; Sun, Liming; He, Sudan; Meng, Lingjun; Liao, Daohong; Liu, Xiao; Ma, Yongfen; Liu, Chunyan; Li, Sisi; Ruan, Hanying; Lei, Xiaoguang; Wang, Xiaodong; Zhang, Zhiyuan

doi:10.1021/acs.jmedchem.6b01196

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

On the basis of its essential role in driving inflammation and disease pathology, cell necrosis has gradually been verified as a promising therapeutic target for treating atherosclerosis, systemic inflammatory response syndrome (SIRS), and ischemia injury, among other diseases. Most necrosis inhi…