Wang, Xiaodong

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

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Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

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Cell death mechanisms and regulationUbiquitin and proteasome pathways

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

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Endonuclease G is an apoptotic DNase when released from mitochondria

Li, L. Y., Luo, X., & Wang, X. (2001) · Nature

Cell death mechanisms and regulationDNA Repair Mechanisms

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The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Wang, Z., Jiang, H., Chen, S., Du, F., & Wang, X. (2012) · Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

Chai, J., Du, C., Wu, J.-W., Kyin, S., Wang, X., & Shi, Y. (2000) · Nature

Cell death mechanisms and regulationUbiquitin and proteasome pathways

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Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

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Cell death mechanisms and regulationMitochondrial Function and Pathology

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Mitochondrial endonuclease G is important for apoptosis in C. elegans

Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X., & Xue, D. (2001) · Nature

Cell death mechanisms and regulationMitochondrial Function and Pathology

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Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

Briggs, M. R., Yokoyama, C., Wang, X., Brown, M. S., & Goldstein, J. L. (1993) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismGenomics and Chromatin Dynamics

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Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

Wang, X., Briggs, M. R., Hua, X., Yokoyama, C., Goldstein, J. L., & Brown, M. S. (1993) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismGenomics and Chromatin Dynamics

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The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

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PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

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Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Xiao, Y., Jin, J., Chang, M., Chang, J.-H., Hu, H., Zhou, X., Brittain, G. C., Stansberg, C., Torkildsen, Ø., Wang, X., et al. (2013) · Nature Medicine

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Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

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A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

Li, D., Xu, T., Cao, Y., Wang, H., Li, L., Chen, S., Wang, X., & Shen, Z. (2015) · Proceedings of the National Academy of Sciences

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Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

Ren, Y., Su, Y., Sun, L., He, S., Meng, L., Liao, D., Liu, X., Ma, Y., Liu, C., Li, S., et al. (2017) · Journal of Medicinal Chemistry

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RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation

Zhang, S., Su, Y., Ying, Z., Guo, D., Pan, C., Guo, J., Zou, Z., Wang, L., Zhang, Z., Jiang, Z., et al. (2019) · Proceedings of the National Academy of Sciences

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