Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Features and development of Coot

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

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Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

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brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

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Purification and biochemical heterogeneity of the mammalian SWI‐SNF complex.

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BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

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Reconstitution of a Core Chromatin Remodeling Complex from SWI/SNF Subunits

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A New Reagent for Direct Difluoromethylation

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A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

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The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated <i>Myc</i> regulation

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation

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A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

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Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

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Discovering New Medicines Targeting Helicases: Challenges and Recent Progress

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Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding

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Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes

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Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma

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Structure of chromatin remodeler Swi2/Snf2 in the resting state

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Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart

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Crystal structures of MBP fusion proteins

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Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner

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BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo

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BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility

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MITF-Independent Pro-Survival Role of BRG1-Containing SWI/SNF Complex in Melanoma Cells

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Integrated Strategies for Identifying Leads That Target the NS3 Helicase of the Hepatitis C Virus

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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

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PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

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Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

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Role of SWI/SNF chromatin remodeling genes in lung cancer development

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SWI/SNF Chromatin Remodeling and Human Malignancies

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Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex

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The SWI/SNF Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer

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