The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Bioactive Secondary Metabolites from Bacillus subtilis: A Comprehensive Review
Abstract
Bacillus subtilis is widely underappreciated for its inherent biosynthetic potential. This report comprehensively summarizes the known bioactive secondary metabolites from B. subtilis and highlights potential applications as plant pathogen control agents, drugs, and biosurfactants. B. subtilis is well known for the production of cyclic lipopeptides exhibiting strong surfactant and antimicrobial activities, such as surfactins, iturins, and fengycins. Several polyketide-derived macrolides as well as nonribosomal peptides, dihydroisocoumarins, and linear lipopeptides with antimicrobial properties have been reported, demonstrating the biosynthetic arsenal of this bacterium. Promising efforts toward the application of B. subtilis strains and their natural products in areas of agriculture and medicine are underway. However, industrial-scale availability of these compounds is currently limited by low fermentation yields and challenging accessibility via synthesis, necessitating the development of genetically engineered strains and optimized cultivation processes. We hope that this review will attract renewed interest in this often-overlooked bacterium and its impressive biosynthetic skill set.
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Citations
Cites
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Bacillus lipopeptides: versatile weapons for plant disease biocontrol
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Biosynthesis of Nonribosomal Peptides
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Cited by
Frenemies of the soil: Bacillus and Pseudomonas interspecies interactions
Lyng, M., & Kovács, Á. T. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.02.003 · Cited by 94
Influence of B. subtilis 3NA mutations in spo0A and abrB on surfactin production in B. subtilis 168
Klausmann, P., Lilge, L., Aschern, M., Hennemann, K., Henkel, M., Hausmann, R., & Morabbi Heravi, K. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01679-z · Cited by 31
Hiller, E., Off, M., Hermann, A., Vahidinasab, M., Benatto Perino, E. H., Lilge, L., & Hausmann, R. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02531-w · Cited by 21
“The species Bacillus subtilis is known for the biosynthesis of various secondary metabolites with bioactive properties [1].”
Background
Metadata
- Authors
- Kaspar, F., Neubauer, P., & Gimpel, M.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-07-09
- Volume
- 82
- Issue
- 7
- Pages
- 2038-2053
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2961022631
- Cited by
- 284
- References
- 127
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaspar, F., Neubauer, P., & Gimpel, M. (2019). Bioactive Secondary Metabolites from Bacillus subtilis: A Comprehensive Review. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.9b00110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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