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Cited by 20Block Copolymer Self-AssemblyAdvanced Polymer Synthesis and Characterizationbiodegradable polymer synthesis and properties

Stereocomplex-Driven Morphological Transition of Coil–Rod–Coil Poly(lactic acid)-Based Cylindrical Nanoparticles

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Xie, Yujie, Yu, Wei, Xia, Tianlai, O’Reilly, Rachel K., Dove, Andrew P.·2023·Macromolecules
DOI 10.1021/acs.macromol.3c00653PMC PMC10569100
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Abstract

High Resolution Image Download MS PowerPoint Slide The stereocomplexation of poly(lactic acid) (PLA) enantiomers opens up an avenue for the formation of new materials with enhanced performance, specifically regarding their mechanical and thermal resistance and resistance to hydrolysis. Despite these useful features, the study of the stereocomplexation between block copolymers based on PLA in solution is limited, and a comprehensive understanding of this phenomenon is urgently needed. Herein, triblock copolymers of poly( N -hydroxyethyl acrylamide) and PL(or D)LA in which PLA was midblock (PHEAAm y - b -PL(D)LA x - b -PHEAAm y ) were synthesized and assembled into cylindrical micelles via crystallization-driven self-assembly . The stereocomplexation between enantiomeric micelles facilitates the morphological transition, and the transformation process was investigated in detail by varying the aging temperature, block composition, and solvent. It was found that the solubility of the copolymers played a vital role in determining the occurrence and the speed of the chain exchange between the micelles and the unimers, which thereafter has a significant impact on the shape transition. These results lead to a deeper understanding of the stereocomplex-driven morphological transition process and provide valuable guidance for further optimization of the transition under physiological conditions as a new category of stimuli-responsive systems for biomedical applications.

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  • Such an effect is likely depending on the size of the phases, as small nanodroplets of one blend component are associated with reinforcement of the blend, comparable to composite formation, as shown in poly(ethyleneco-methacrylate)/poly(vinylidene fluoride) blends.

    “Such an effect is likely furthermore depending on the size of the phases, as small nanodroplets of one blend component are associated with reinforcement of the blend, comparable to composite formation, as e.g. has been shown in poly(ethyleneco-methacrylate)/poly(vinylidene fluoride) blends.88”

    From Correlative characterization of stereocomplex formation in blends of aliphatic polyester P(PCL <sub> <i>m</i> </sub> - <i>b</i> -PLLA <sub> <i>n</i> </sub> ) multiblock-copolymers and PDLA (2026) · cites this paper as [88]

    The Results and Discussion section describes the size of PLA stereocomplex assemblies and the factors affecting their morphological transition, not reinforcement of polymer blends. Searches for the named poly(ethylene-co-methacrylate)/poly(vinylidene fluoride) blend and for nanodroplet-related reinforcement found no passage addressing the claim. Page numbers were unavailable in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Xie, Y., Yu, W., Xia, T., O’Reilly, R. K., & Dove, A. P.
Affiliations
  • Shanghai University (CN)
  • School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
  • University of Birmingham (GB)
Corresponding author
  • O’Reilly, Rachel K.
  • Dove, Andrew P.
ORCID
Venue
Macromolecules
Publisher
American Chemical Society (ACS)
Published
2023-09-25
Volume
56
Issue
19
Pages
7689-7697
ISSN
  • 0024-9297 (ISSN-L)
  • 1520-5835
DOI
10.1021/acs.macromol.3c00653
PMC
PMC10569100
OpenAlex
W4387011244
Cited by
20
References
0
Citations by year
2026: 5 · 2025: 10 · 2024: 5
FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Macromolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (22205133)
  • H2020 European Research Council (681559)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
stereocomplexation, polylactic acid, block copolymers, cylindrical micelles, morphological transition, crystallization-driven self-assembly, chain exchange, stimuli-responsive materials, biodegradable polymers, drug delivery

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