Cited by 535biodegradable polymer synthesis and propertiesPolymer crystallization and propertiesBlock Copolymer Self-Assembly

Poly(lactic acid) stereocomplexes: A decade of progress

Tsuji, Hideto·2016·Advanced Drug Delivery Reviews

Abstract

Upon blending enantiomeric poly(l-lactide) [i.e., poly(l-lactic acid) (PLLA)] and poly(d-lactide) (PDLA) [i.e., poly(d-lactic acid) (PDLA)] or synthesis of stereo block poly(lactide) [i.e., poly(lactic acid) (PLA)], a stereocomplex (SC) is formed. PLA SC has a higher melting temperature (or heat resistance), mechanical performance, and hydrolysis-resistance compared to those of neat PLLA and PDLA. Because of such effects, PLA SC has been extensively studied in terms of biomedical and pharmaceutical applications as well as commodity, industrial, and environmental applications. Stereocomplexation stabilizes and strengthens PLA-based hydrogel or nanoparticles for biomedical applications. Stereocomplexation increases the barrier property of PLA-based materials and thereby prolongs drug release from PLA based materials. In addition, PLA SC is attracting significant attention because it can act as a nucleating agent for the widely used biobased polymer PLLA and thereby the heat resistance of PLLA-based materials can be enhanced. Interestingly, a wide variety of SCs other than PLA SC are found to have been formed in the enantiomeric substituted PLA blends and stereo block substituted PLA polymers. In the present review article, a decade of progress in investigation of PLA SCs is summarized.

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Crossref · 10.1016/j.addr.2016.04.017

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Authors
Tsuji, H.
Affiliations
Toyohashi University of Technology (JP)
Corresponding author
Tsuji, Hideto
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2016-12
Volume
107
Pages
97-135
ISSN
0169-409X (ISSN-L)
OpenAlex
W2343346371
Cited by
535
References
309
Citations by year
2026: 39 · 2025: 42 · 2024: 47 · 2023: 54 · 2022: 67 · 2021: 53 · 2020: 66 · 2019: 59 · 2018: 49 · 2017: 41 · 2016: 18
FWCI
2.99
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
Keywords
poly(L-lactic acid), poly(D-lactide), stereocomplexation, nucleating agents, melting point, hydrolytic stability, hydrogels, nanoparticles, drug release, barrier properties, biomedical applications, pharmaceutical applications
MeSH terms
Hot Temperature, Polyesters, Stereoisomerism

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