Quaternized Chitosan/Poly(acrylic acid) Polyelectrolyte Complex Hydrogels with Tough, Self-Recovery, and Tunable Mechanical Properties
Abstract
Quaternized chitosan (QCh) was homogeneously synthesized by reacting chitosan with 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC) in alkali/urea aqueous solution for the first time. The structure and solution properties of QCh were characterized by using element analysis, FT-IR, 13 C NMR, SEC-LLS, rheology, viscometer, and ξ-potential measurements. Subsequently, polyelectrolyte complex (PEC) hydrogels were constructed by in situ polymerization of acrylic acid (AA) monomers in the concentrated QCh solution. The structure and mechanical behavior of the prepared hydrogels were systematic studied. Because of the high charge density and solubility of QCh, strong electrostatic interactions were formed in the hydrogels and endowed them tough with self-recovery properties. The mechanical behavior of the hydrogels was accurately tuned from stiff and viscoelastic to soft and elastic by changing the poly(acrylic acid) (PAA) content. The regulation mechanism relied on the remarkable difference in the chain segmental mobility between QCh and PAA. Moreover, the QCh/PAA PEC hydrogels displayed excellent solvent-induced shape-memory behavior due to the reversible properties of the ionic bonds. In summary, we offered a novel modification method for chitosan and opened up a new avenue to construct chitosan-based hydrogels with outstanding mechanical properties.
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For a classical SMP stent (Tg: 40 °C) triggered by heating from surrounding water (70 °C), implantation fails due to premature deployment during the delivery path.
“For a classical SMP stent (Tg: 40 °C) 26 triggered by heating from the surrounding water (70 °C), the implantation fails due to the premature deployment during the delivery path (Fig. 4c and Supplementary Video 2).”
From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [26]
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From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [26]
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Shape memory polymer with programmable recovery onset
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Background
- Authors
- You, J., Xie, S., Cao, J., Ge, H., Xu, M., Zhang, L., & Zhou, J.
- Affiliations
- Wuhan University (CN)
- East China Normal University (CN)
- Corresponding author
- Zhou, Jinping
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-27
- Volume
- 49
- Issue
- 3
- Pages
- 1049-1059
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2343606709
- Cited by
- 187
- References
- 55
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 23 · 2023: 20 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 18 · 2018: 22 · 2017: 12 · 2016: 10
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- Funders
- Program for New Century Excellent Talents in University (NCET-11-0415)
- National Natural Science Foundation of China (51273067, 51273151, 51473128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Keywords
- quaternized chitosan, polyelectrolyte complex hydrogels, poly(acrylic acid), chitosan modification, 3-chloro-2-hydroxypropyltrimethylammonium chloride, in situ polymerization, tough hydrogels, self-recovery, tunable mechanical properties, ionic bonding, electrostatic interactions
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