Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172 · see citing works

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828 · see citing works

Mitochondria and cancer

Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works

The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence

Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · see citing works

Bioresponsive materials

Lü, Y., Aimetti, A. A., Langer, R., & Gu, Z. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.75 · Cited by 1,432 · see citing works

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

Zhang, W., Hu, S., Yin, J., He, W., Lu, W., Ma, M., Gu, N., & Zhang, Y. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b12070 · Cited by 948 · see citing works

Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels

Harada, H., Inoue, M., Itasaka, S., Hirota, K., Morinibu, A., Shinomiya, K., Zeng, L., Ou, G., Zhu, Y., Yoshimura, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3314 · Cited by 676 · see citing works

Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH‐/H2O2‐Responsive UCL Imaging and Oxygen‐Elevated Synergetic Therapy

Fan, W., Bu, W., Shen, B., He, Q., Cui, Z., Liu, Y., Zheng, X., Zhao, K., & Shi, J. (2015) · Advanced Materials · doi:10.1002/adma.201405141 · Cited by 668 · see citing works

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

Prasad, P., Gordijo, C. R., Abbasi, A. Z., Maeda, A., Ip, A., Rauth, A. M., DaCosta, R. S., & Wu, X. Y. (2014) · ACS Nano · doi:10.1021/nn405773r · Cited by 632 · see citing works

Modulation of Hypoxia in Solid Tumor Microenvironment with MnO 2 Nanoparticles to Enhance Photodynamic Therapy

Zhu, W., Dong, Z., Fu, T., Liu, J., Chen, Q., Li, Y., Zhu, R., Xu, L., & Liu, Z. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600676 · Cited by 590 · see citing works

Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species

Alexandre, J., Hu, Y., Lu, W., Pelicano, H., & Huang, P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3914 · Cited by 380 · see citing works

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., & Sung, H.-W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01784 · Cited by 372 · see citing works

Mental disorders in cancer patients.A study of 100 psychiatric referrals

Levine, P. M., Silberfarb, P. M., & Lipowski, Z. J. (1978) · Cancer · doi:10.1002/1097-0142(197809)42:3 · Cited by 243 · see citing works

Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A phase II multicentric study

Díaz‐Rubio, E., Sastre, J., Zaniboni, A., Labianca, R., Cortés-Funes, H., de Braud, F., Boni, C., Benavides, M., Dallavalle, G., & Homerin, M. (1998) · Annals of Oncology · doi:10.1023/a:1008200825886 · Cited by 228 · see citing works

MnO2 Gatekeeper: An Intelligent and O2‐Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2‐Sensitive MRI

Ma, Z., Jia, X., Bai, J., Ruan, Y., Wang, C., Li, J., Zhang, M., & Jiang, X. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201604258 · Cited by 218 · see citing works

Synthesizing MnO 2 nanosheets from graphene oxide templates for high performance pseudosupercapacitors

Zhao, G., Li, J., Jiang, L., Dong, H., Wang, X., & Hu, W. (2011) · Chemical Science · doi:10.1039/c1sc00722j · Cited by 217 · see citing works

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158485 · Cited by 189 · see citing works

Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Fotiadis, C. I., Stoidis, C. N., Spyropoulos, B. G., & Zografos, E. D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6453 · Cited by 180 · see citing works

ZD1839 (‘Iressa’), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model

Williams, K. J., Telfer, B. A., Stratford, I. J., & Wedge, S. R. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600182 · Cited by 175 · see citing works

Enhancement of tumor radioresponse of a murine mammary carcinoma by paclitaxel.

Milas, L., Hunter, N. R., Mason, K. A., Kurdoglu, B., & Peters, L. J. (1994) · PubMed · Cited by 126 · see citing works

Light‐Triggered Clustered Vesicles with Self‐Supplied Oxygen and Tissue Penetrability for Photodynamic Therapy against Hypoxic Tumor

Li, J., Wei, K., Zuo, S., Xu, Y., Zha, Z., Ke, W., Chen, H., & Ge, Z. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702108 · Cited by 126 · see citing works

Influences of graphene oxide support on the electrochemical performances of graphene oxide-MnO2 nanocomposites

Ouyang, C., Jiang, J., Zhou, W., Lai, L., Xi, L., Lam, Y. M., Shen, Z., Khezri, B., & Yu, T. (2011) · Nanoscale Research Letters · doi:10.1186/1556-276x-6-531 · Cited by 112 · see citing works

Phase II Study of External Irradiation and Weekly Paclitaxel for Nonmetastatic, Unresectable Pancreatic Cancer: RTOG-98-12

Rich, T. A., Harris, J., Abrams, R. A., Erickson, B. E., Doherty, M. K., Paradelo, J. C., Small, W. C., Safran, H. P., & Wanebo, H. J. (2004) · American Journal of Clinical Oncology · doi:10.1097/01.coc.0000046300.88847.bf · Cited by 101 · see citing works

Mimicking Drug-Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes

Pan, J., Wang, Y., Pan, H., Zhang, C., Zhang, X., Fu, Y., Zhang, X., Yu, C., Sun, S., & Yan, X. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201603440 · Cited by 81 · see citing works

Paclitaxel and concurrent radiation for locally advanced pancreatic and gastric cancer: a phase I study.

Safran, H. P., King, T. P., Choy, H., Hesketh, P. J., Wolf, B., Altenhein, E., Sikov, W. M., Rosmarin, A. G., Akerley, W., Radie-Keane, K., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.3.901 · Cited by 79 · see citing works

Molecular Switch For the Assembly of Lipophilic Drug Incorporated Plasma Protein Nanoparticles and In Vivo image

Gong, G., Xu, Y., Zhou, Y., Meng, Z., Ren, G., Zhao, Y., Zhang, X., Wu, J., & Hu, Y. (2011) · Biomacromolecules · doi:10.1021/bm201401s · Cited by 76 · see citing works

130-nm Albumin–Bound Paclitaxel Enhances Tumor Radiocurability and Therapeutic Gain

Wiedenmann, N. E., Valdecanas, D. R., Hunter, N. R., Hyde, S. J., Buchholz, T. A., Milas, L., & Mason, K. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2534 · Cited by 71 · see citing works

Enhanced tolerance and antitumor efficacy by docetaxel-loaded albumin nanoparticles

Tang, X., Wang, G., Shi, R., Jiang, K., Meng, L., Ren, H., Wu, J., & Hu, Y. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1049720 · Cited by 55 · see citing works

Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers

Bischoff, P. L., Altmeyer, A., & Dumont, F. J. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902824172 · Cited by 47 · see citing works

A Randomized Feasibility Study Evaluating the Effect of Radiotherapy Alone Or Combined with 5-Fluorouracil in the Treatment of Locally Recurrent Or Inoperable Colorectal Carcinoma

Overgaard, M., Bertelsen, K., Dalmark, M., Gadeberg, C. C., von der Maase, H., Overgaard, J., & Sell, A. (1993) · Acta Oncologica · doi:10.3109/02841869309096116 · Cited by 43 · see citing works

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi, M., Chehelgerdi, M., Allela, O. Q. B., Pecho, R. D. C., Narayanan, J., Rao, D. P., Thamaraikani, T., Vasanthan, M., Viktor, P., Lakshmaiya, N., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01865-0 · Cited by 1,116 · see citing works

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

Meng, L., Cheng, Y., Tong, X., Gan, S., Ding, Y., Zhang, Y., Wang, C., Xu, L., Zhu, Y., Wu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03590 · Cited by 269 · see citing works

Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy

Cai, X., Zhu, Q., Zeng, Y., Zeng, Q., Chen, X., & Zhan, Y. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s218085 · Cited by 250 · see citing works

Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

Shen, Z., Ma, Q., Zhou, X., Zhang, G., Hao, G., Sun, Y. Y., & Cao, J. (2021) · NPG Asia Materials · doi:10.1038/s41427-021-00303-1 · Cited by 227 · see citing works

Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

Sahu, A., Kwon, I., & Tae, G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119578 · Cited by 218 · see citing works

Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy

Zhang, R., Chen, L., Liang, Q. Y., Xi, J., Zhao, H., Jin, Y., Gao, X., Yan, X., Gao, L., & Fan, K. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101317 · Cited by 201 · see citing works

Multifunctional MnO 2 nanoparticles for tumor microenvironment modulation and cancer therapy

Yang, G., Ji, J., & Liu, Z. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1720 · Cited by 187 · see citing works

Two-stage oxygen delivery for enhanced radiotherapy by perfluorocarbon nanoparticles

Zhou, Z., Zhang, B., Wang, H., Yuan, A., Hu, Y., & Wu, J. (2018) · Theranostics · doi:10.7150/thno.27598 · Cited by 139 · see citing works

Prototypic Heptamethine Cyanine Incorporating Nanomaterials for Cancer Phototheragnostic

Leitão, M. M., de Melo‐Diogo, D., Alves, C. G., Lima‐Sousa, R., & Correia, I. J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901665 · Cited by 131 · see citing works

Biomedical applications of MnO2 nanomaterials as nanozyme-based theranostics

Sisakhtnezhad, S., Rahimi, M., & Mohammadi, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114833 · Cited by 122 · see citing works

Hypoxia signaling in cancer: Implications for therapeutic interventions

Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works

Oxygen Production of Modified Core–Shell CuO@ZrO2 Nanocomposites by Microwave Radiation to Alleviate Cancer Hypoxia for Enhanced Chemo-Microwave Thermal Therapy

Chen, Z., Niu, M., Chen, G., Wu, Q., Tan, L., Fu, C., Ren, X., Zhong, H., Xu, K., & Meng, X. (2018) · ACS Nano · doi:10.1021/acsnano.8b07749 · Cited by 112 · see citing works

E. coli Membrane Vesicles as a Catalase Carrier for Long-Term Tumor Hypoxia Relief to Enhance Radiotherapy

Zai, W., Kang, L., Dong, T., Wang, H., Yin, L., Gan, S., Lai, W., Ding, Y., Hu, Y., & Wu, J. (2021) · ACS Nano · doi:10.1021/acsnano.1c07621 · Cited by 97 · see citing works

Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology

Navya, P. N., Mehla, S., Begum, A., Chaturvedi, H. K., Ojha, R., Hartinger, C. G., Plebanski, M., & Bhargava, S. K. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300768 · Cited by 93 · see citing works

MnO 2 -Based nanosystems for cancer therapy

Wen, J., Yang, K., & Sun, S. (2020) · Chemical Communications · doi:10.1039/d0cc02782k · Cited by 88 · see citing works

The interactions of paclitaxel with tumour microenvironment

Yu, D., Lou, Z., Ma, F.-Y., & Najafi, M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108555 · Cited by 88 · see citing works

Chemical Modulation of Glucose Metabolism with a Fluorinated CaCO3 Nanoregulator Can Potentiate Radiotherapy by Programming Antitumor Immunity

Dong, Z., Wang, C., Gong, Y., Zhang, Y., Fan, Q., Hao, Y., Li, Q., Wu, Y., Zhong, X., Yang, K., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c02688 · Cited by 87 · see citing works

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

García‐Hevia, L., Bañobre‐López, M., & Gallo, J. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201802851 · Cited by 82 · see citing works

Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy

Zhou, Z., Zhang, B., Zai, W., Kang, L., Yuan, A., Hu, Y., & Wu, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901987116 · Cited by 82 · see citing works

Tumor Targeted Albumin Coated Bismuth Sulfide Nanoparticles (Bi2S3) as Radiosensitizers and Carriers of Curcumin for Enhanced Chemoradiation Therapy

Nosrati, H., Charmi, J., Salehiabar, M., Abhari, F., & Danafar, H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00489 · Cited by 64 · see citing works

Tumor microenvironment triggered local oxygen generation and photosensitizer release from manganese dioxide mineralized albumin-ICG nanocomplex to amplify photodynamic immunotherapy efficacy

Jiang, N., Zhou, Z., Xiong, W. H., Chen, J., Shen, J., Li, R., & Ye, R. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.06.053 · Cited by 63 · see citing works

Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

Liu, X., Zhou, Y., Xie, W., Liu, S., Zhao, Q., & Huang, W. (2020) · Small Methods · doi:10.1002/smtd.202000566 · Cited by 62 · see citing works

Manganese dioxide (MnO2) based nanomaterials for cancer therapies and theranostics

Zhu, D. Y., Zhu, X., Ren, S., Lu, Y., & Zhu, H. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1815209 · Cited by 61 · see citing works

Targeted Regulation of Blood–Brain Barrier for Enhanced Therapeutic Efficiency of Hypoxia-Modifier Nanoparticles and Immune Checkpoint Blockade Antibodies for Glioblastoma

Meng, L., Wang, C., Lu, Y., Sheng, G., Yang, L., Wu, Z., Xu, H., Han, C., Lu, Y., & Han, F. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00347 · Cited by 61 · see citing works

Nanomaterials for radiotherapeutics-based multimodal synergistic cancer therapy

Yang, X., Gao, L., Guo, Q., Li, Y., Ma, Y., Yang, J., Gong, C., & Cheng, Y. (2020) · Nano Research · doi:10.1007/s12274-020-2722-z · Cited by 58 · see citing works

Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress

Ortíz, R., Quiñonero, F., García-Pinel, B., Fuel, M., Mesas, C., Cabeza, L., Melguizo, C., & Prados, J. C. (2021) · Cancers · doi:10.3390/cancers13092058 · Cited by 57 · see citing works

Investigating the size-dependent structural, optical, dielectric, and photocatalytic properties of benign-synthesized ZnO nanoparticles

Shoeb, M., Ahmad, S., Mashkoor, F., Khan, M. N., Hasan, I., Singh, B. R., & Jeong, C. (2023) · Journal of Physics and Chemistry of Solids · doi:10.1016/j.jpcs.2023.111707 · Cited by 55 · see citing works

Self-targeting platinum(IV) amphiphilic prodrug nano-assembly as radiosensitizer for synergistic and safe chemoradiotherapy of hepatocellular carcinoma

Xiao, X., Wang, Y., Chen, J., Qin, P., Chen, P., Zhou, D., & Pan, Y. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121793 · Cited by 54 · see citing works

Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Zhou, Z., Jiang, N., Chen, J., Zheng, C., Guo, Y., Ye, R., Qi, R., & Shen, J. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01124-8 · Cited by 51 · see citing works

Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

Sundaram, A., Peng, L., Chai, L., Xie, Z., Ponraj, J. S., Wang, X., Wang, G., Zhang, B., Nie, G., Xie, N., et al. (2020) · Nanoscale · doi:10.1039/d0nr06271e · Cited by 50 · see citing works

Construction of Surface-Modified Polydopamine Nanoparticles for Sequential Drug Release and Combined Chemo-Photothermal Cancer Therapy

Cui, W., Wang, P., Huang, Z., He, D., Zhu, W., Liu, H., Chen, Z., Wang, W. “., Li, Y., Shen, J., et al. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c01164 · Cited by 50 · see citing works

Manganese Dioxide‐Based Nanocarrier Delivers Paclitaxel to Enhance Chemotherapy against Orthotopic Glioma through Hypoxia Relief

Jiang, S., Li, X., Zhang, F., Mao, J., Cao, M., Zhang, X., Huang, S., Duan, X., & Shen, J. (2022) · Small Methods · doi:10.1002/smtd.202101531 · Cited by 49 · see citing works

Therapeutic application of manganese-based nanosystems in cancer radiotherapy

Pan, S., Sun, Z., Zhao, B., Miao, L., Zhou, Q., Chen, T., & Zhu, X. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122321 · Cited by 49 · see citing works

Manganese Dioxide-Based Nanomaterials for Medical Applications

Jiang, Y., Zhao, J., & Zhang, D. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01852 · Cited by 49 · see citing works

Advances of Nanomedicine in Radiotherapy

Liu, W., Chen, B., Zheng, H., Xing, Y., Chen, G., Zhou, P., Qian, L., & Min, Y. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111757 · Cited by 49 · see citing works

Oxygen-Based Nanocarriers to Modulate Tumor Hypoxia for Ameliorated Anti-Tumor Therapy: Fabrications, Properties, and Future Directions

Li, X., Wu, Y., Zhang, R., Bai, W., Ye, T., & Wang, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.683519 · Cited by 49 · see citing works

Albumin-stabilized manganese-based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors

Xu, K. W., Zhao, Z., Zhang, J., Xue, W., Tong, H., Liu, H., & Zhang, W. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02341k · Cited by 34 · see citing works

Emerging nanozymes for potentiating radiotherapy and radiation protection

Chong, Y., Ning, J., Min, S., Ye, J., & Ge, C. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.03.054 · Cited by 33 · see citing works

Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer

Wang, H., Ju, J., Wang, S., Zhang, Y., Liu, C.-Y., Wang, T., Yu, X. M., Wang, F., Cheng, X.-R., Wang, K., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.812534 · Cited by 29 · see citing works

Integration of Manganese Dioxide‐Based Nanomaterials for Biomedical Applications

Sun, Y., Wang, Y., Liu, Y., Wang, H., Yang, C., Liu, X., & Wang, F. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200093 · Cited by 28 · see citing works

Oxygen-rich chemotherapy via modified Abraxane to inhibit the growth and metastasis of triple-negative breast cancer

Meng, L., Gan, S., Zhou, Y., Cheng, Y., Ding, Y., Tong, X., Wu, J., Hu, Y., & Yuan, A. (2018) · Biomaterials Science · doi:10.1039/c8bm00753e · Cited by 25 · see citing works

Manganese systemic distribution is modulated in vivo during tumor progression and affects tumor cell migration and invasion in vitro

Stelling, M. P., Soares, M. A., Cardoso, S. C., Motta, J. M., de Abreu, J. C., Antunes, M. J. M., de Freitas, V. G., Moraes, J. A., Castelo-Branco, M. T. L., Perez, C. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-95190-5 · Cited by 20 · see citing works

Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

An, Y., Chen, C., Zhu, J., Dwivedi, P., Zhao, Y., & Wang, Z. (2019) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-019-1864-6 · Cited by 18 · see citing works

Preparation of copper oxide nanoparticles coated with bovine serum albumin for delivery of methotrexate

Mohammadhassan, Z., Mohammadkhani, R., Mohammadi, A., Zaboli, K. A., Kaboli, S., Rahimi, H., Nosrati, H., & Danafar, H. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.103015 · Cited by 17 · see citing works

Ultrasound-triggered cascade reaction via MnO2-CpG nanoparticles for boosting pyroptosis-mediated cancer immunotherapy

Wang, X., Shen, M., Sun, Y., Tang, Q., Du, L., Yang, S., Zou, H., Zhao, X., Chen, X., Li, J., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102394 · Cited by 16 · see citing works

Design of manganese-based nanomaterials for pharmaceutical and biomedical applications

Jain, P., Jangid, A. K., Pooja, D., & Kulhari, H. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00779k · Cited by 15 · see citing works

The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

Atloo, T., Mohammadkhani, R., Mohammadi, A., Zaboli, K. A., Kaboli, S., Rahimi, H., Nosrati, H., & Danafar, H. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-022-02401-9 · Cited by 15 · see citing works

Manganese-Based Nanotherapeutics for Targeted Treatment of Breast Cancer

Khan, M., Ullah, R., Shah, S. M., Farooq, U., & Li, J. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00040 · Cited by 12 · see citing works

Alleviating hypoxia by integrating MnO 2 with metal–organic frameworks coated upconversion nanocomposites for enhanced photodynamic therapy in vitro

Zhou, J., Jiang, M., Zhang, Q., Jiang, Y., Wang, H., & Sun, L. (2024) · Dalton Transactions · doi:10.1039/d4dt02605e · Cited by 10 · see citing works

Hypoxia responsive phytonanotheranostics: A novel paradigm towards fighting cancer

Acharya, S., & Misra, R. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102549 · Cited by 10 · see citing works

Multifaceted Applications of Nanomaterials in Colorectal Cancer Management: Screening, Diagnostics, and Therapeutics

He, X., Chang, Z., & Niu, M. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s520616 · Cited by 8 · see citing works

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis

Marzęda, P., Wróblewska-Łuczka, P., Florek-Łuszczki, M., Góralczyk, A., & Łuszczki, J. J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00557-2 · Cited by 7 · see citing works

Bioengineered Nanozymes for Orthopedic Degenerative Diseases: From Catalytic Mechanisms to Multimodal Therapy

Peng, L., Chen, Y., Song, H., Shi, J., & Sun, K. (2025) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70016 · Cited by 5 · see citing works

Smart bismuth-based platform: A focus on radiotherapy and multimodal systems

Kavousi, N., Nazari, M., Toossi, M. T. B., Azimian, H., & Alibolandi, M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106136 · Cited by 5 · see citing works

Biomimetic multifunctional nanoparticles for improved radiotherapy and immunotherapy in cancer treatment

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Zhao, L., Qiu, G.-H., Wang, K., Chen, H., Ruan, F., Liu, N., Deng, Z., Yao, Y., Guo, D., Wang, D., et al. (2020) · Nanoscale Advances · doi:10.1039/c9na00786e · Cited by 4 · see citing works

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Deepa, Mittal, A., Taxak, S., Tandon, V., & Pati, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114054 · Cited by 1 · see citing works

Oxygen therapy in cancer treatment: progress & promises

(2018) · International Journal of Biosciences (IJB) · doi:10.12692/ijb/13.1.72-85

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Rai, D. (2022) · doi:10.22541/au.165888617.79233708/v1

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Nguyen, D. N., & Nguyen, K. T. (2023) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-44630-6_25

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Veisi, K., Aghaz, F., Izadi, Z., Shirzadikia, S., Jaymand, M., & Almasi, T. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4610341

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Jain, P., Babu, K. G., Alle, M., & Taylor, M. L. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-99-6597-7_6

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Asiri, M., AlKhafaje, Z., Hussein, U. A., Adel, Z., Alkadir, O. K. A., Aldulaimi, A., Saeed, S. M., Taher, W. M., Alwan, M., & Smerat, A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107798

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Ahirwar, V. P., Leharwani, M., Alqahtani, T., Shmrany, H. A., Gupta, G., Patil, U. K., & Kesharwani, P. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108180

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Zhu, M., He, L., Quan, L., Cui, C., Li, D., Lou, T., & Jia, X. (2026) · Discover Nano · doi:10.1186/s11671-026-04887-x

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Zhu, W., Dong, Z., Fu, T., Liu, J., Chen, Q., Li, Y., Zhu, R., Xu, L., & Liu, Z. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600676 · Cited by 590 · see citing works

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Prasad, P., Gordijo, C. R., Abbasi, A. Z., Maeda, A., Ip, A., Rauth, A. M., DaCosta, R. S., & Wu, X. Y. (2014) · ACS Nano · doi:10.1021/nn405773r · Cited by 632 · see citing works

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Song, M., Liu, T., Shi, C., Zhang, X., & Chen, X. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b06779 · Cited by 664 · see citing works

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Abbasi, A. Z., Gordijo, C. R., Amini, M. A., Maeda, A., Rauth, A. M., DaCosta, R. S., & Wu, X. Y. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3475 · Cited by 121 · see citing works

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