Cited by 2,144Cancer Cells and MetastasisEffects of Radiation ExposureCancer, Hypoxia, and Metabolism

The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence

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Barker, Holly E., Paget, James T. E., Khan, Aadil A., Harrington, Kevin J.·2015·Nature Reviews Cancer

Abstract

Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.

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  • Generation of intratumoral O2 using bioactive albumin-MnO2 nanoparticles is feasible to improve the efficacy of radiotherapy.

    “Generation of intratumoral O2 is also feasible to improve the efficacy of radiotherapy by using bioactive albumin-MnO2 nanoparticles [94].”

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Authors
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J.
Affiliations
Institute of Cancer Research (GB)
Corresponding author
Barker, Holly E.
Venue
Nature Reviews Cancer
Published
2015-06-24
Volume
15
Issue
7
Pages
409-425
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W1912124796
Cited by
2,144
References
200
Citations by year
2026: 181 · 2025: 215 · 2024: 246 · 2023: 242 · 2022: 249 · 2021: 256 · 2020: 230 · 2019: 175 · 2018: 161 · 2017: 119 · 2016: 63 · 2015: 7
FWCI
12.40
Type
journal article
Language
en
Update notices
erratum (2015-07-24)
Open access
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Cancer Research UK (C46 ⁄ A10588, C7224/A13407, A13407, 13407)
  • National Institute for Health and Care Research (CL-2014-22-003)
  • Rosetrees Trust
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
tumor microenvironment, radioresistance (biology), radiotherapy, tumor stroma, tumor recurrence, vascular changes, immunological changes, combination therapy, molecularly targeted agents
MeSH terms
Animals, Fibroblasts, Humans, Immune Tolerance, Neoplasm Recurrence, Local, Neoplasms, Radiation Tolerance, Cell Hypoxia, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Tumor Microenvironment

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