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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing

Open access
Zhao, Xin, Guo, Baolin, Wu, Hao, Liang, Yongping, Ma, Peter X.·2018·Nature Communications

Abstract

Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.

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Metadata

Authors
Zhao, X., Guo, B., Wu, H., Liang, Y., & Ma, P. X.
Venue
Nature Communications
Published
2018-07-17
Volume
9
Issue
1
Pages
2784-2784
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2857318559
Cited by
1,161
References
5
FWCI
62.46
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing. https://app.cochat.ai/papers/10.1038/s41467-018-04998-9
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Zhao, X., Guo, B., Wu, H., Liang, Y., & Ma, P. X. (2018). Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing. Nature Communications. https://doi.org/10.1038/s41467-018-04998-9

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