Multifunctional Au Modified Ti 3 C 2 -MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy
Abstract
Ti 3 C 2 -MXene-based composites provide multifunctional interfaces in diagnosis and treatment of tumors. Herein, we proposed a multifunctional nanoplatform based on Ti 3 C 2 -MXene–Au nanocomposites, which combines photothermal properties and peroxidase-like activity, accomplishing synergistic photothermal therapy (PTT) and enzyme dynamic therapy (EDT) accompanied by photoacoustic (PA) and thermal dual-mode imaging in vivo . Furthermore, PTT induces immunogenic cell death, and EDT promotes cell apoptosis, facilitating dendritic cell (DC) maturation and T cell infiltration into the tumor. On this basis, the antibody OX40 (αOX40) was utilized to further contribute immune therapy for reversing the immunosuppressive tumor microenvironment by activating CD4 + and CD8 + T cells. In summary, a triune of PTT/EDT/antitumor immune therapy is achieved by combining Ti 3 C 2 -MXene–Au nanocomposites and αOX40, which possesses several strong features of good biocompatibility, NIR-controlled targeting, significant cancer cell killing, and satisfactory biosafety in vitro and in vivo . Our work might highlight the promising application of MXene-based nanoplatforms for cancer therapy.
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Chang et al. proposed a multifunctional nano platform based on Ti3C2-MXene Au nanocomposite, which realized the triune of PTT/Enzyme kinetics therapy/antitumor immune therapy, and accompanied by photoacoustic (PA) and thermal dual-mode imaging in vivo.
“Chang et al. proposed a multifunctional nano platform based on Ti3C2-MXene Au nanocomposite, which realized the triune of PTT/Enzyme kinetics therapy/antitumor immune therapy, and accompanied by photoacoustic (PA) and thermal dual-mode imaging in vivo.87”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [87]
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Smart nanoparticles for cancer therapy
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- Authors
- Chang, X., Wu, Q., Wu, Y., Xi, X., Cao, J., Chu, H., Liu, Q., Li, Y., Wu, W., Fang, X., & Chen, F.
- Affiliations
- Jilin University (CN)
- Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun, 130033 Jilin, China
- Corresponding author
- Fang, Xuedong
- Chen, Fangfang
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-10-12
- Volume
- 22
- Issue
- 20
- Pages
- 8321-8330
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W4304692003
- Cited by
- 109
- References
- 44
- Citations by year
- 2026: 19 · 2025: 36 · 2024: 29 · 2023: 24 · 2022: 1
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jilin Province (YDZJ202101ZYTS024)
- Ministry of Science and Technology of the People's Republic of China (2021YFC2400600, 2021YFC2400603)
- China Postdoctoral Science Foundation (2022TQ0118)
- National Natural Science Foundation of China (32271446)
- Jilin Department of Health (2018SCZ005)
- Norman Bethune Program of Jilin University (2022B21, 2022B37)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › MXene and MAX Phase Materials
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Keywords
- Ti3C2 MXene, gold nanocomposites, photothermal therapy, peroxidase-like activity, photoacoustic imaging, infrared thermography, immunogenic cell death, dendritic cell maturation, T cell infiltration, cancer immunotherapy, immunosuppressive tumor microenvironment
- MeSH terms
- Photothermal Therapy, Humans, Neoplasms, Peroxidases, Phototherapy, Titanium, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Nanoparticles, Nanocomposites, Tumor Microenvironment
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