The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing
Abstract
Diabetic wounds are highly susceptible to bacterial infection, which can lead to the formation of bacterial biofilms, making diabetic wound healing a major challenge. In this study, a composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared to eliminate biofilms and promote vascular regeneration. This microneedle released minocycline under near-infrared (NIR) light, effectively penetrating bacterial biofilms. The photothermal properties of the conjugated polymers, combined with the antibacterial action of minocycline, contribute to the eradication of biofilms and the elimination of drug-resistant bacteria. Moreover, it regulated the wound microenvironment by reducing the level of oxidative stress, as well as the production of inflammatory factors at the wound site. Meanwhile, it effectively boosted cell migration and promoted angiogenesis to accelerate diabetic wound healing. This composited microneedle for biofilm elimination represents a promising approach for promoting diabetic wound healing.
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The biofilm matrix: multitasking in a shared space
Flemming, H.-C., van Hullebusch, E. D., Neu, T. R., Nielsen, P. H., Seviour, T., Stoodley, P., Wingender, J., & Wuertz, S. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00791-0 · Cited by 983
Diabetic Wound-Healing Science
Burgess, J. L., Wyant, W. A., Abdo Abujamra, B., Kirsner, R. S., & Jozic, I. (2021) · Medicina · doi:10.3390/medicina57101072 · Cited by 928
The wound microbiota: microbial mechanisms of impaired wound healing and infection
Uberoi, A., McCready-Vangi, A., & Grice, E. A. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01035-z · Cited by 864
Engineered biomaterials for in situ tissue regeneration
Gaharwar, A. K., Singh, I., & Khademhosseini, A. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0209-x · Cited by 859
Biofilm-specific antibiotic tolerance and resistance
Olsen, I. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2323-z · Cited by 737
Advanced bandages for diabetic wound healing
Matoori, S., Veves, A., & Mooney, D. J. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe4839 · Cited by 498
Biofilms in Chronic Wounds: Pathogenesis and Diagnosis
Wu, Y.-K., Cheng, N.-C., & Cheng, C.-M. (2019) · Trends in Biotechnology · doi:10.1016/j.tibtech.2018.10.011 · Cited by 473
Advances in Antimicrobial Microneedle Patches for Combating Infections
Jamaledin, R., Yiu, C. K. Y., Zare, E. N., Niu, L., Vecchione, R., Chen, G., Gu, Z., Tay, F. R., & Makvandi, P. (2020) · Advanced Materials · doi:10.1002/adma.202002129 · Cited by 461
Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing
Chi, J., Zhang, X., Chen, C., Shao, C., Zhao, Y., & Wang, Y. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.02.004 · Cited by 442
Self-citationYin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c06036 · Cited by 380
Cited by
Hao, M., Wang, Y., Wang, Y., Su, S., Zhou, Y., & Wei, S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165250 · Cited by 25
Yang, G., Kang, H., Zhu, Y., Wu, H., Zhang, M., Zeng, X., Peng, Y., Wan, W., & Yi, Y. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.017 · Cited by 21
Bao, S., Jiang, A., Li, P., Liao, F., Liu, G., Chen, L., Zhou, P., Zhu, Z., Reis, R. L., Kundu, S. C., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.163026 · Cited by 16
Wang, F., Deng, S.-P., Liu, L., Zhang, N., Song, C., Zhou, Y., Fu, X., Jiang, Y., Liu, M., Hu, Y., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c04223 · Cited by 15
Farhadi, M., Moghari, S., Naqvi, M., & Khonakdar, H. A. (2025) · Polymer Engineering and Science · doi:10.1002/pen.70159 · Cited by 14
Metadata
- Authors
- Wang, Z., Li, B., Nie, C., Zhang, R., Qu, S., Shao, Q., Zhang, X., Li, J., Li, W., Li, H., Xiao, J., & Xing, C.
- Affiliations
- Hebei University of Technology (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Zhang, Ran
- Xiao, Jian
- Xing, Chengfen
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2025-02-06
- Volume
- 25
- Issue
- 7
- Pages
- 2911-2921
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W4407218855
- Semantic Scholar
- ba74b6857b264c5fc20e7dce07c8d4ffe92e5c50
- Cited by
- 46
- References
- 42
- Citations by year
- 2026: 25 · 2025: 21
- FWCI
- 29.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Hebei Province (B2023202024, B2023202030, B2024202013)
- National Key Research and Development Program of China (2023YFC3404204)
- China Postdoctoral Science Foundation (2023M740968)
- National Natural Science Foundation of China (22077025, 32401121)
- Hebei Provincial Department of Science and Technology (22567601H)
- the Postdoctoral Fellowship Program of CPSF (GZC20240367)
- the Educational Committee of Hebei Province (BJ2025110)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- diabetic wound healing, bacterial biofilm eradication, photothermal therapy, minocycline, near-infrared light, basic fibroblast growth factor, angiogenesis, vascular regeneration, antibacterial drug delivery, oxidative stress, inflammation, cell migration, drug-resistant bacteria
- MeSH terms
- Photothermal Therapy, Angiogenesis, Animals, Anti-Bacterial Agents, Diabetes Mellitus, Experimental, Humans, Infrared Rays, Needles, Polymers, Wound Healing, Fibroblast Growth Factor 2, Biofilms, Neovascularization, Physiologic, Rats, Nanoparticles
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- CoChat. (2026). Citation check: Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing. https://app.cochat.ai/papers/10.1021/acs.nanolett.4c06284
- The paper
- Wang, Z., Li, B., Nie, C., Zhang, R., Qu, S., Shao, Q., Zhang, X., Li, J., Li, W., Li, H., Xiao, J., & Xing, C. (2025). Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing. Nano Letters. https://doi.org/10.1021/acs.nanolett.4c06284
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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