Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes
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In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens. By exploiting the plasmonic field enhancement in the vicinity of engineered and surface-modified nanoantennas, the proposed biosensor is able to capture the vibrational fingerprints of lipid molecules and monitor in real time the formation kinetics of planar biomimetic membranes in aqueous environments. Furthermore, we show that this plasmonic biosensor features high-field enhancement extending over tens of nanometers away from the surface, matching the size of typical bioassays while preserving high sensitivity.
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Molecular enrichment strategies bring additional working requirements for specific molecules, impeding global molecular recognition.
“The molecular enrichment strategies, including functionalized chemical bonding17,18, chemical reaction19,20, physical adsorption21–23, optical trapping24 as well as passive trapping by undercut structure25–28 bring in the additional working requirements (e.g., chemical stimuli, temperature, pressure, pump power, etc.) for specific molecules, impeding the system for global molecular recognition.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [17]
Three approaches to optimize nanoantenna sensing by increasing coupling efficiency μ are hotspot release, molecule enrichment, and squeezing adjacent nanoantennas into a nanogap.
“Figure 2b summarizes three approaches to optimize nanoantenna sensing by increasing μ. Hotspots release is proposed to increase accessible sensing areas for analytes, which are usually blocked by the substrate, to further enhance the coupling efficiency25–28.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [17]
Using the design principle of wavelength multiplexing, the WMHNA can be designed to cover all IR fingerprint ranges by engineering the antenna length for specific molecular monitoring like proteins, sugars, lipids, nucleic acids, and volatile organic compounds (VOCs).
“Using the design principle of wavelength multiplexing, the WMHNA can be designed to cover all IR fingerprint ranges by engineering the antenna length for specific molecular monitoring like proteins48, sugars49, lipids17, nucleic acids57, and volatile organic compounds (VOCs)58.”
From Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy (2022) · cites this paper as [17]
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Rodrigo, D., Tittl, A., Ait-Bouziad, N., John-Herpin, A., Limaj, O., Kelly, C., Yoo, D., Wittenberg, N. J., Oh, S.-H., Lashuel, H. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04594-x · Cited by 269 · see citing works
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Self-citation
- Authors
- Limaj, O., Etezadi, D., Wittenberg, N. J., Rodrigo, D., Yoo, D., Oh, S.-H., & Altug, H.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- University of Minnesota (US)
- Corresponding author
- Altug, Hatice
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-13
- Volume
- 16
- Issue
- 2
- Pages
- 1502-1508
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2338127759
- Cited by
- 196
- References
- 44
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 21 · 2023: 9 · 2022: 18 · 2021: 24 · 2020: 16 · 2019: 27 · 2018: 27 · 2017: 23 · 2016: 9
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission (2013-625673, 644956)
- ?cole Polytechnique F?d?rale de Lausanne
- University of Minnesota
- National Institute of General Medical Sciences (R01 GM092993)
- Swiss National Science Foundation (133583)
- Center of MicroNano Technology, University of Louisville
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- label-free detection, lipid membranes, biomimetic membranes, nanoantennas, plasmonic field enhancement, vibrational spectroscopy, real-time monitoring, surface modification
- MeSH terms
- Kinetics, Membrane Lipids, Spectrophotometry, Infrared, Water, Biosensing Techniques, Surface Plasmon Resonance, Nanostructures
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