The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bacteria-Mediated Hypoxia-Specific Delivery of Nanoparticles for Tumors Imaging and Therapy
Abstract
The hypoxia region in a solid tumor has been recognized as a complex microenvironment revealing very low oxygen concentration and deficient nutrients. The hypoxic environment reduces the susceptibility of the cancer cells to anticancer drugs, low response of free radicals, and less proliferation of cancer cells in the center of the solid tumors. However, the reduced oxygen surroundings provide an appreciable habitat for anaerobic bacteria to colonize. Here, we present the bacteria-mediated targeting hypoxia to offer the expandable spectra for diagnosis and therapy in cancer diseases. Two delivery approaches involving a cargo-carrying method and an antibody-directed method were designed to deliver upconversion nanorods for imaging and Au nanorods for photothermal ablation upon near-infrared light excitation for two forms of the anaerobic Bifidobacterium breve and Clostridium difficile. The antibody-directed strategy shows the most effective treatment giving stronger imaging and longer retention period and effective therapy to completely remove tumors.
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Cites
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Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses
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Cited by
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
Chen, J., Luo, H., Liu, Y., Zhang, W., Li, H., Luo, T., Zhang, K., Zhao, Y., & Liu, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b08225 · Cited by 451
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Fan, J., Peng, M., Wang, H., Zheng, H., Liu, Z., Li, C., Wang, X., Liu, X., Cheng, S., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201808278 · Cited by 363
Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319
Metadata
- Authors
- Luo, C.-H., Huang, C.-T., Su, C.-H., & Yeh, C.-S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-05-09
- Volume
- 16
- Issue
- 6
- Pages
- 3493-3499
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2346043912
- Cited by
- 256
- References
- 14
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luo, C.-H., Huang, C.-T., Su, C.-H., & Yeh, C.-S. (2016). Bacteria-Mediated Hypoxia-Specific Delivery of Nanoparticles for Tumors Imaging and Therapy. Nano Letters. https://doi.org/10.1021/acs.nanolett.6b00262
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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