The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Engineered Bacterial Bioreactor for Tumor Therapy via Fenton‐Like Reaction with Localized H2O2 Generation
Abstract
Synthetic biology based on bacteria has been displayed in antitumor therapy and shown good performance. In this study, an engineered bacterium Escherichia coli MG1655 is designed with NDH‐2 enzyme (respiratory chain enzyme II) overexpression (Ec‐pE), which can colonize in tumor regions and increase localized H 2 O 2 generation. Following from this, magnetic Fe 3 O 4 nanoparticles are covalently linked to bacteria to act as a catalyst for a Fenton‐like reaction, which converts H 2 O 2 to toxic hydroxyl radicals (•OH) for tumor therapy. In this constructed bioreactor, the Fenton‐like reaction occurs with sustainably synthesized H 2 O 2 produced by engineered bacteria, and severe tumor apoptosis is induced via the produced toxic •OH. These results show that this bioreactor can achieve effective tumor colonization, and realize a self‐supplied therapeutic Fenton‐like reaction without additional H 2 O 2 provision.
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Self-citationProgrammable probiotics for detection of cancer in urine
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Self-citationPhototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
Cao, C., Wang, X., Yang, N., Song, X., & Dong, X. (2022) · Chemical Science · doi:10.1039/d1sc05482a · Cited by 298
Self-citationAkolpoglu, M. B., Alapan, Y., Dogan, N. O., Baltaci, S. F., Yasa, O., Aybar Tural, G., & Sitti, M. (2022) · Science Advances · doi:10.1126/sciadv.abo6163 · Cited by 293
Prebiotics‐Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer
Zheng, D., Li, R., An, J., Xie, T., Han, Z., Xu, R., Fang, Y., & Zhang, X. (2020) · Advanced Materials · doi:10.1002/adma.202004529 · Cited by 274
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Metadata
- Authors
- Fan, J., Peng, M., Wang, H., Zheng, H., Liu, Z., Li, C., Wang, X., Liu, X., Cheng, S., & Zhang, X.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-02-25
- Volume
- 31
- Issue
- 16
- Pages
- e1808278-e1808278
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2917538021
- Cited by
- 363
- References
- 33
- FWCI
- 24.70
- Type
- journal article
- Language
- en
- Open access
- closed
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