The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis
Abstract
Large magnetic nanoparticles or aggregates are advantageous in their magnetic resonance properties over ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), but the former are cleared faster from the blood pool. Therefore, the "smart" strategy of intracellular aggregation of USPIO NPs is required for enhanced T2-weighted MR imaging. Herein, employing an enzyme-instructed condensation reaction, we rationally designed a small molecule Ac-Asp-Glu-Val-Asp-Cys(StBu)-Lys-CBT (1) to covalently modify USPIO NPs to prepare monodispersive Fe3O4@1 NPs. In vitro results showed that Fe3O4@1 NPs could be subjected to caspase 3 (Casp3)-instructed aggregation. T2 phantom MR imaging showed that the transverse molar relaxivity (r2) of Fe3O4@1 NPs with Casp3 or apoptotic HepG2 cells was significantly larger than those of control groups. In vivo tumor MR imaging results indicated that Fe3O4@1 NPs could be specifically applied for enhanced T2 MR imaging of tumor apoptosis. We propose that the enzyme-instructed intracellular aggregation of Fe3O4 NPs could be a novel strategy for the design of "smart" probes for efficient T2 MR imaging of in vivo biomarkers.
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Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
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Cited by
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, D., Bu, W., Ehlerding, E. B., Cai, W., & Shi, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00316a · Cited by 484
Palanisamy, S., & Wang, Y.-M. (2019) · Dalton Transactions · doi:10.1039/c9dt00459a · Cited by 230
Self-citationMagnetic Nanostructures: Rational Design and Fabrication Strategies toward Diverse Applications
Wang, S., Xu, J., Li, W., Sun, S., Gao, S., & Hou, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00370 · Cited by 129
Self-citationDe Simone, U., Roccio, M., Gribaldo, L., Spinillo, A., Caloni, F., & Coccini, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071993 · Cited by 55
Metadata
- Authors
- Yuan, Y., Ding, Z., Qian, J., Zhang, J., Xu, J., Dong, X., Han, T., Ge, S., Luo, Y., Wang, Y., Zhong, K., & Liang, G.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-04-04
- Volume
- 16
- Issue
- 4
- Pages
- 2686-2691
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2328547225
- Cited by
- 183
- References
- 3
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, Y., Ding, Z., Qian, J., Zhang, J., Xu, J., Dong, X., Han, T., Ge, S., Luo, Y., Wang, Y., Zhong, K., & Liang, G. (2016). Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis. Nano Letters. https://doi.org/10.1021/acs.nanolett.6b00331
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