The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy
Abstract
Disulfide bonds have been widely used to develop reduction-responsive drug-delivery systems (DDS) for cancer therapy. We propose that disulfide bonds might be also used as an oxidation-responsive linkage just like thioether bonds, which can be oxidized to hydrophilic sulfoxide or sulphone in the presence of oxidation stimuli. To test our hypothesis, we design three novel paclitaxel-citronellol conjugates linked via different lengths of disulfide-bond-containing carbon chain. The prodrugs can self-assemble into uniform-size nanoparticles with impressively high drug loading (>55%). As expected, the disulfide-bond-bridged prodrug nanoparticles show redox dual-responsive drug release. More interestingly, the position of disulfide bonds in the carbon chain linkage has profound impacts on the redox dual responsiveness, thereby affecting the drug release, cytotoxicity, pharmacokinetics, biodistribution, and in vivo antitumor efficacy of prodrug nanoassemblies. The redox dual-responsive mechanism is elucidated, and how the position of disulfide bonds in the carbon chain affects the redox dual responsiveness and antitumor efficiency of prodrug nanoassemblies is also clarified. Our findings give new insight into the stimuli responsiveness of disulfide bonds and provide a good foundation for the development of novel redox dual-responsive DDS for cancer therapy.
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Photonic Synapses Based on Inorganic Perovskite Quantum Dots for Neuromorphic Computing
Wang, Y., Lv, Z., Chen, J., Wang, Z., Zhou, Y., Zhou, L., Chen, X., & Han, S. (2018) · Advanced Materials · doi:10.1002/adma.201802883 · Cited by 700
Self-citationLuo, C., Sun, J., Liu, D., Sun, B., Miao, L., Musetti, S., Li, J., Han, X., Du, Y., Li, L., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b01632 · Cited by 443
Self-citationTumor Redox Heterogeneity‐Responsive Prodrug Nanocapsules for Cancer Chemotherapy
Wang, J., Sun, X., Mao, W., Sun, W., Tang, J., Sui, M., Shen, Y., & Gu, Z. (2013) · Advanced Materials · doi:10.1002/adma.201300929 · Cited by 395
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PEGylation in anti-cancer therapy: An overview
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Cancer‐Associated, Stimuli‐Driven, Turn on Theranostics for Multimodality Imaging and Therapy
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Prodrug-based nanoparticulate drug delivery strategies for cancer therapy
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Self-citationGemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug
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Cited by
Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy
Sun, B., Luo, C., Zhang, X., Guo, M., Sun, M., Yu, H., Chen, Q., Yang, W., Wang, M., Zuo, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11193-x · Cited by 319
Self-citationCancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems
Dianat-Moghadam, H., Heidarifard, M., Jahanban-Esfahlan, R., Panahi, Y., Hamishehkar, H., Pouremamali, F., Rahbarghazi, R., & Nouri, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.043 · Cited by 140
Zhang, H.-Y., Sun, C.-Y., Adu-Frimpong, M., Yu, J.-N., & Xu, X.-M. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.11.049 · Cited by 70
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Metadata
- Authors
- Sun, B., Luo, C., Yu, H., Zhang, X., Chen, Q., Yang, W., Wang, M., Kan, Q., Zhang, H., Wang, Y., He, Z., & Sun, J.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-05-04
- Volume
- 18
- Issue
- 6
- Pages
- 3643-3650
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2799378760
- Cited by
- 426
- References
- 25
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, B., Luo, C., Yu, H., Zhang, X., Chen, Q., Yang, W., Wang, M., Kan, Q., Zhang, H., Wang, Y., He, Z., & Sun, J. (2018). Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy. Nano Letters. https://doi.org/10.1021/acs.nanolett.8b00737
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