The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
PEGylation in anti-cancer therapy: An overview
Open accessAbstract
Advanced drug delivery systems using poly(ethylene glycol) (PEG) is an important development in anti-cancer therapy. PEGylation has the ability to enhance the retention time of the therapeutics like proteins, enzymes small molecular drugs, liposomes and nanoparticles by protecting them against various degrading mechanisms active inside a tissue or cell, which consequently improves their therapeutic potential. PEGylation effectively alters the pharmacokinetics (PK) of a variety of drugs and dramatically improves the pharmaceutical values; recent development of which includes fabrication of stimuli-sensitive polymers/smart polymers and polymeric micelles to cope of with the pathophysiological environment of targeted site with less toxic effects and more effectiveness. This overview discusses PEGylation involving proteins, enzymes, low molecular weight drugs, liposomes and nanoparticles that has been developed, clinically tried for anti-cancer therapy during the last decade.
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Cites
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273
Polymeric micelles—A new generation of colloidal drug carriers
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Delivery of Therapeutic Proteins
Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22054 · Cited by 532
Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
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“The water-soluble PEG blocks with a molecular weight from 1 to 15 kDa are considered as the most suitable hydrophilic corona-forming blocks [87].”
BackgroundAscierto, P. A., Scala, S., Castello, G., Daponte, A., Simeone, E., Ottaiano, A., Beneduce, G., De Rosa, V., Izzo, F., Melucci, M. T., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.0933 · Cited by 238
Cited by
Hoang Thi, T. T., Pilkington, E. H., Nguyen, D. H., Lee, J. S., Park, K. D., & Truong, N. P. (2020) · Polymers · doi:10.3390/polym12020298 · Cited by 668
Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy
Sun, B., Luo, C., Yu, H., Zhang, X., Chen, Q., Yang, W., Wang, M., Kan, Q., Zhang, H., Wang, Y., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00737 · Cited by 426
Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery Systems
Yun, W. S., Kim, J., Lim, D.-K., Kim, D.-H., Jeon, S. I., & Kim, K. (2023) · Nanomaterials · doi:10.3390/nano13152225 · Cited by 76
PLGA-PEG-RA-based polymeric micelles for tumor targeted delivery of irinotecan
Emami, J., Maghzi, P., Hasanzadeh, F., Sadeghi, H., Mirian, M., & Rostami, M. (2018) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1340950 · Cited by 36
Nakahara, Y., Endo, Y., Matsuda, Y., Nagaki, A., Takahashi, K., Kawaguchi, T., & Kato, K. (2024) · Synthesis · doi:10.1055/a-2077-6187 · Cited by 5
Metadata
- Authors
- Mishra, P., Nayak, B., & Dey, R. K.
- Venue
- Asian Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 11
- Issue
- 3
- Pages
- 337-348
- ISSN
- 1818-0876 (ISSN-L)
- OpenAlex
- W1630018437
- Cited by
- 382
- References
- 8
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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