The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tumor Redox Heterogeneity‐Responsive Prodrug Nanocapsules for Cancer Chemotherapy
Abstract
A prodrug forms nanocapsules responsive to tumor GSH/ROS heterogeneity releasing the parent drug SN38 via thiolysis in the presence of GSH (glutathione) or via enhanced hydrolysis due to ROS (reactive oxygen species)-oxidation of the linker, giving rise to high in vitro cytotoxicity and in vivo anticancer therapeutic activity. The nanocapsules are a suitable size for tumor targeting by means of the EPR effect and have a fixed SN38 loading content of 35 wt%, ideal for translational nanomedicine.
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Citations
Cites
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Cited by
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Self-citationThe Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066
The role of micelle size in tumor accumulation, penetration, and treatment
Wang, J., Mao, W., Lock, L. L., Tang, J., Sui, M., Sun, W., Cui, H., Xu, D., & Shen, Y. (2015) · ACS Nano · doi:10.1021/acsnano.5b02017 · Cited by 635
Self-citationRedox-responsive polymers for drug delivery: from molecular design to applications
Huo, M., Yuan, J., Tao, L., & Wei, Y. (2014) · Polym. Chem. · doi:10.1039/c3py01192e · Cited by 561
Moradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514
Metadata
- Authors
- Wang, J., Sun, X., Mao, W., Sun, W., Tang, J., Sui, M., Shen, Y., & Gu, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2013-06-06
- Volume
- 25
- Issue
- 27
- Pages
- 3670-3676
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2038720439
- Cited by
- 395
- References
- 1
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, J., Sun, X., Mao, W., Sun, W., Tang, J., Sui, M., Shen, Y., & Gu, Z. (2013). Tumor Redox Heterogeneity‐Responsive Prodrug Nanocapsules for Cancer Chemotherapy. Advanced Materials. https://doi.org/10.1002/adma.201300929
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
