The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy
Abstract
Near-infrared (NIR)-II fluorescence agents hold great promise for deep-tissue photothermal therapy (PTT) of cancers, which nevertheless remains restricted by the inherent nonspecificity and toxicity of PTT. In response to this challenge, we herein develop a hydrogen sulfide (H 2 S)-activatable nanostructured photothermal agent (Nano-PT) for site-specific NIR-II fluorescence-guided PTT of colorectal cancer (CRC). Our in vivo studies reveal that this theranostic Nano-PT probe is specifically activated in H 2 S-rich CRC tissues, whereas it is nonfunctional in normal tissues. Activation of Nano-PT not only emits NIR-II fluorescence with deeper tissue penetration ability than conventional fluorescent probes but also generates high NIR absorption resulting in efficient photothermal conversion under NIR laser irradiation. Importantly, we establish NIR-II imaging-guided PTT of CRC by applying the Nano-PT agent in tumor-bearing mice, which results in complete tumor regression with minimal nonspecific damages. Our studies thus shed light on the development of cancer biomarker-activated PTT for precision medicine.
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Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G.-Q., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 783
Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer
Li, J., & Pu, K. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00569 · Cited by 412
Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases
Zeng, Z., Liew, S. S., Wei, X., & Pu, K. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107877 · Cited by 359
Metadata
- Authors
- Shi, B., Yan, Q., Tang, J., Xin, K., Zhang, J., Zhu, Y., Xu, G., Wang, R., Chen, J., Gao, W., Zhu, T., Shi, J., Fan, C., Zhao, C., & Tian, H.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-09-21
- Volume
- 18
- Issue
- 10
- Pages
- 6411-6416
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2891587274
- Cited by
- 185
- References
- 1
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shi, B., Yan, Q., Tang, J., Xin, K., Zhang, J., Zhu, Y., Xu, G., Wang, R., Chen, J., Gao, W., Zhu, T., Shi, J., Fan, C., Zhao, C., & Tian, H. (2018). Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy. Nano Letters. https://doi.org/10.1021/acs.nanolett.8b02767
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