The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets
Abstract
Both diffusion-limited and perfusion-limited hypoxia are associated with tumor progression, metastasis, and the resistance to therapeutic modalities. A strategy that can efficiently overcome both types of hypoxia to enhance the efficacy of cancer treatment has not been reported yet. Here, it is shown that by using biomimetic ultrathin graphdiyne oxide (GDYO) nanosheets, both types of hypoxia can be simultaneously addressed toward an ideal photodynamic therapy (PDT). The GDYO nanosheets, which are oxidized and exfoliated from graphdiyne (GDY), are able to efficiently catalyze water oxidation to release O 2 and generate singlet oxygen ( 1 O 2 ) using near-infrared irradiation. Meanwhile, GDYO nanosheets also exhibit excellent light-to-heat conversion performance with a photothermal conversion efficiency of 60.8%. Thus, after the GDYO nanosheets are coated with iRGD peptide-modified red blood membrane (i-RBM) to achieve tumor targeting, the biomimetic GDYO@i-RBM nanosheets can simultaneously enhance tumor reoxygenation and blood perfusion for PDT. This study provides new insights into utilizing novel water-splitting materials to relieve both diffusion- and perfusion-limited hypoxia for the development of a novel therapeutic platform.
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“The efficiency of PDT is limited due to hypoxic regions and vascular aberrations in tumor tissue.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [432]
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Metadata
- Authors
- Jiang, W., Zhang, Z., Wang, Q., Dou, J., Zhao, Y., Ma, Y., Liu, H., Xu, H., & Wang, Y.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Xu, Hangxun
- Wang, Yucai
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-05-28
- Volume
- 19
- Issue
- 6
- Pages
- 4060-4067
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2946915376
- Cited by
- 146
- References
- 59
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 7 · 2023: 23 · 2022: 33 · 2021: 27 · 2020: 33 · 2019: 3
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2017YFA0205600, 2017YFA0207301, 2015CB351903)
- Ministry of Education of the People's Republic of China
- National Natural Science Foundation of China (51773191, 51633008, 21875235, 51573176)
- Chinese Academy of Sciences (QYZDB-SSW-SLH018)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
- Keywords
- photodynamic therapy, tumor hypoxia, tumor reoxygenation, blood perfusion, water oxidation catalysis, singlet oxygen generation, photothermal conversion, iRGD peptide, near-infrared irradiation, cancer therapy
- MeSH terms
- Tumor Hypoxia, Animals, Carbon, Humans, Mice, Inbred BALB C, Neoplasms, Oxides, Oxygen, Photochemotherapy, Biomimetic Materials, Cell Line, Tumor, Nanostructures
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