Cited by 146Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Photocatalysis Techniques

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Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets

Jiang, Wei, Zhang, Zhen, Wang, Qin, Dou, Jiaxiang, Zhao, Yangyang, Ma, Yinchu, Liu, Huarong, Xu, Hangxun, Wang, Yucai·2019·Nano Letters

DOI 10.1021/acs.nanolett.9b01458

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Abstract

Both diffusion-limited and perfusion-limited hypoxia are associated with tumor progression, metastasis, and the resistance to therapeutic modalities. A strategy that can efficiently overcome both types of hypoxia to enhance the efficacy of cancer treatment has not been reported yet. Here, it is shown that by using biomimetic ultrathin graphdiyne oxide (GDYO) nanosheets, both types of hypoxia can be simultaneously addressed toward an ideal photodynamic therapy (PDT). The GDYO nanosheets, which are oxidized and exfoliated from graphdiyne (GDY), are able to efficiently catalyze water oxidation to release O 2 and generate singlet oxygen ( 1 O 2 ) using near-infrared irradiation. Meanwhile, GDYO nanosheets also exhibit excellent light-to-heat conversion performance with a photothermal conversion efficiency of 60.8%. Thus, after the GDYO nanosheets are coated with iRGD peptide-modified red blood membrane (i-RBM) to achieve tumor targeting, the biomimetic GDYO@i-RBM nanosheets can simultaneously enhance tumor reoxygenation and blood perfusion for PDT. This study provides new insights into utilizing novel water-splitting materials to relieve both diffusion- and perfusion-limited hypoxia for the development of a novel therapeutic platform.

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Authors: Jiang, W., Zhang, Z., Wang, Q., Dou, J., Zhao, Y., Ma, Y., Liu, H., Xu, H., & Wang, Y.
Affiliations: University of Science and Technology of China (CN)
Corresponding author: Xu, Hangxun
Wang, Yucai
ORCID: Jiang, Wei
Zhang, Zhen
Wang, Qin
Dou, Jiaxiang
Zhao, Yangyang
Ma, Yinchu
Liu, Huarong
Xu, Hangxun
Wang, Yucai
Venue: Nano Letters
Publisher: American Chemical Society (ACS)
Published: 2019-05-28
Volume: 19
Issue: 6
Pages: 4060-4067
ISSN: 1530-6984 (ISSN-L)
1530-6992
DOI: 10.1021/acs.nanolett.9b01458
OpenAlex: W2946915376
Cited by: 146
References: 59
Citations by year: 2026: 3 · 2025: 17 · 2024: 7 · 2023: 23 · 2022: 33 · 2021: 27 · 2020: 33 · 2019: 3
FWCI: 8.45
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-045 (stm-asf)
Locations: Nano Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Science and Technology of the People's Republic of China (2017YFA0205600, 2017YFA0207301, 2015CB351903)
Ministry of Education of the People's Republic of China
National Natural Science Foundation of China (51773191, 51633008, 21875235, 51573176)
Chinese Academy of Sciences (QYZDB-SSW-SLH018)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
Keywords: photodynamic therapy, tumor hypoxia, tumor reoxygenation, blood perfusion, water oxidation catalysis, singlet oxygen generation, photothermal conversion, iRGD peptide, near-infrared irradiation, cancer therapy
MeSH terms: Tumor Hypoxia, Animals, Carbon, Humans, Mice, Inbred BALB C, Neoplasms, Oxides, Oxygen, Photochemotherapy, Biomimetic Materials, Cell Line, Tumor, Nanostructures

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Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets

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