The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy
Abstract
Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life of ROS is very short and the intracellular diffusion depth is limited, which impairs ER localization and thus limits ER stress induction. To solve the problem, we synthesized reduction-sensitive Ds-sP NPs (PEG-s-s-1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[amino(polyethylene glycol)-2000] nanoparticles) loaded with an efficient ER-targeting photosensitizer TCPP-T ER (4,4′,4″,4′″-(porphyrin-5,10,15,20-tetrayl)tetrakis( N -(2-((4-methylphenyl)sulfonamido)ethyl)benzamide). The resulting Ds-sP/TCPP-T ER NPs could selectively accumulate in the ER and locally generate ROS under near-infrared (NIR) laser irradiation, which induced ER stress, amplified ICD, and activated immune cells, leading to augmented immunotherapy effect. This study presents a novel ICD amplifying, ER-targeting PDT strategy that can effectively eradicate primary tumors under NIR exposure, as well as distant tumors through an abscopal effect.
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Cites
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176
Light in diagnosis, therapy and surgery
Yun, S. H., & Kwok, S. J. J. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0008 · Cited by 793
Xu, J., Xu, L., Wang, C., Yang, R., Zhuang, Q., Han, X., Dong, Z., Zhu, W., Peng, R., & Liu, Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b00715 · Cited by 695
Dying cells actively regulate adaptive immune responses
Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442
Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 433
Self-citationRecent advances in nanomaterial-based synergistic combination cancer immunotherapy
Sang, W., Zhang, Z., Dai, Y., & Chen, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00896e · Cited by 405
Self-citationOrganic Dye Based Nanoparticles for Cancer Phototheranostics
Cai, Y., Si, W., Huang, W., Chen, P., Shao, J., & Dong, X. (2018) · Small · doi:10.1002/smll.201704247 · Cited by 306
Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy
Feng, B., Hou, B., Xu, Z., Saeed, M., Yu, H., & Li, Y. (2019) · Advanced Materials · doi:10.1002/adma.201902960 · Cited by 245
Cited by
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Ji, B., Wei, M., & Yang, B. (2022) · Theranostics · doi:10.7150/thno.67300 · Cited by 544
Zheng, P., Ding, B., Jiang, Z., Xu, W., Li, G., Ding, J., & Chen, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04778 · Cited by 359
Self-citationSinglet Oxygen “Afterglow” Therapy with NIR‐II Fluorescent Molecules
Zou, J., Li, L., Zhu, J., Li, X., Yang, Z., Huang, W., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202103627 · Cited by 155
Self-citationImmunogenic Cell Death-Based Cancer Vaccines
Jin, M.-Z., & Wang, X.-P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697964 · Cited by 99
Lee, J.-H., Yang, S.-B., Park, S. J., Kweon, S., Ma, G., Seo, M., Kim, H. R., Kang, T.-B., Lim, J.-H., & Park, J. (2025) · ACS Nano · doi:10.1021/acsnano.4c16128 · Cited by 37
Metadata
- Authors
- Deng, H., Zhou, Z., Yang, W., Lin, L.-S., Wang, S., Niu, G., Song, J., & Chen, X.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-02-19
- Volume
- 20
- Issue
- 3
- Pages
- 1928-1933
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3008938139
- Cited by
- 363
- References
- 30
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deng, H., Zhou, Z., Yang, W., Lin, L.-S., Wang, S., Niu, G., Song, J., & Chen, X. (2020). Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy. Nano Letters. https://doi.org/10.1021/acs.nanolett.9b05210
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