The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death
Abstract
Immunogenic cell death (ICD), a manner of tumor cell death that can trigger antitumor immune responses, has received extensive attention as a potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca 2+ ) nanomodulators have been developed for cancer therapy through mitochondrial Ca 2+ overload, their ICD-inducing properties have not been explored. Herein, an acid-sensitive PEG-decorated calcium carbonate (CaCO 3 ) nanoparticle incorporating curcumin (CUR; a Ca 2+ enhancer) ( PEG CaCUR) was prepared using a simple one-pot strategy. PEG CaCUR served as not only a Ca 2+ nanomodulator inducing efficient mitochondrial Ca 2+ overload but also an ICD inducer during improved synergistic cancer therapy. Combination of PEG CaCUR with ultrasound (US), PEG CaCUR+US, led to an enhanced ICD effect attributable to the enhanced mitochondrial Ca 2+ overload, along with subsequent upregulation of reactive oxygen species levels. PEG CaCUR also facilitates photoacoustic/fluorescence dual-mode imaging, as well as effectively suppressing tumor growth and metastasis, indicating promising theranostic properties.
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Cites
Immunogenic cell death in cancer and infectious disease
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Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy
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Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
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Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy
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Cited by
ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy
Ding, B., Chen, H., Tan, J., Meng, Q., Zheng, P., Ma, P., & Lin, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202215307 · Cited by 348
Self-citationMetal-based anticancer agents as immunogenic cell death inducers: the past, present, and future
Sen, S., Won, M., Levine, M. S., Noh, Y., Sedgwick, A. C., Kim, J. S., Sessler, J. L., & Arambula, J. F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00417d · Cited by 297
Tan, X., Huang, J., Wang, Y., He, S., Jia, L., Zhu, Y., Pu, K., Zhang, Y., & Yang, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202102703 · Cited by 262
Chang, X., Wu, Q., Wu, Y., Xi, X., Cao, J., Chu, H., Liu, Q., Li, Y., Wu, W., Fang, X., et al. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03260 · Cited by 109
Metadata
- Authors
- Zheng, P., Ding, B., Jiang, Z., Xu, W., Li, G., Ding, J., & Chen, X.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-02-17
- Volume
- 21
- Issue
- 5
- Pages
- 2088-2093
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3129581908
- Cited by
- 359
- References
- 24
- FWCI
- 20.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, P., Ding, B., Jiang, Z., Xu, W., Li, G., Ding, J., & Chen, X. (2021). Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death. Nano Letters. https://doi.org/10.1021/acs.nanolett.0c04778
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