Peptides for Vaccine Development
Open accessAbstract
This review discusses peptide epitopes used as antigens in the development of vaccines in clinical trials as well as future vaccine candidates. It covers peptides used in potential immunotherapies for infectious diseases including SARS-CoV-2, influenza, hepatitis B and C, HIV, malaria, and others. In addition, peptides for cancer vaccines that target examples of overexpressed proteins are summarized, including human epidermal growth factor receptor 2 (HER-2), mucin 1 (MUC1), folate receptor, and others. The uses of peptides to target cancers caused by infective agents, for example, cervical cancer caused by human papilloma virus (HPV), are also discussed. This review also provides an overview of model peptide epitopes used to stimulate non-specific immune responses, and of self-adjuvanting peptides, as well as the influence of other adjuvants on peptide formulations. As highlighted in this review, several peptide immunotherapies are in advanced clinical trials as vaccines, and there is great potential for future therapies due the specificity of the response that can be achieved using peptide epitopes.
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- Authors
- Hamley, I. W.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Hamley, Ian W.
- ORCID
- Hamley, Ian W.
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-02-23
- Volume
- 5
- Issue
- 3
- Pages
- 905-944
- ISSN
- 2576-6422 (ISSN-L)
- PMC
- PMC9384901
- OpenAlex
- W4213428209
- Cited by
- 104
- References
- 8
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 37 · 2023: 16 · 2022: 5
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- ACS Applied Bio Materials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- peptide epitopes, peptide vaccine, vaccine development, immunotherapy, SARS-CoV-2, influenza, hepatitis B, hepatitis C, HIV, malaria, cancer vaccines, HER2, MUC1, folate receptor, human papillomavirus, cervical cancer, vaccine adjuvants
- MeSH terms
- Vaccine Development, Adjuvants, Immunologic, Animals, Antigens, Communicable Disease Control, Humans, Neoplasms, Peptides, Cancer Vaccines, Vaccines, Subunit
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