Cross-Presentation, Dendritic Cells, Tolerance and Immunity

Dendritic cells and the control of immunity

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works

Tolerance, Danger, and the Extended Family

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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615 · see citing works

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501 · see citing works

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

Steinman, R. M., & Cohn, Z. A. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.5.1142 · Cited by 2,443 · see citing works

Innate Immunity: The Virtues of a Nonclonal System of Recognition

Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434 · see citing works

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360 · see citing works

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

Albert, M. L., Sauter, B., & Bhardwaj, N. (1998) · Nature · doi:10.1038/32183 · Cited by 2,350 · see citing works

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091 · see citing works

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

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Natural adjuvants: Endogenous activators of dendritic cells

Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601 · see citing works

Consequences of Cell Death

Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357 · see citing works

The immune system evolved to discriminate infectious nonself from noninfectious self

Janeway, C. A. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90198-g · Cited by 1,343 · see citing works

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

Albert, M. L., Pearce, S. F. A., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., & Bhardwaj, N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1359 · Cited by 1,234 · see citing works

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

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Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

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IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

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Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

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A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

Huang, F., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D., & MacPherson, G. G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.435 · Cited by 902 · see citing works

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

Régnault, A., Lankar, D., Lacabanne, V., Rodrı́guez, A., Théry, C., Rescigno, M., Saito, T., Verbeek, S. J., Bonnerot, C., Ricciardi‐Castagnoli, P., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.371 · Cited by 897 · see citing works

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

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Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

Bennett, S. R. M., Carbone, F., Karamalis, F., Miller, J. F. A. P., & Heath, W. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.65 · Cited by 725 · see citing works

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

Kurts, C., Kosaka, H., Carbone, F., Miller, J. F. A. P., & Heath, W. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.2.239 · Cited by 706 · see citing works

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

Shen, Z., Reznikoff, G., Dranoff, G., & Rock, K. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2723 · Cited by 702 · see citing works

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

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Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V. (1993) · Nature · doi:10.1038/361359a0 · Cited by 615 · see citing works

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

Finegood, D. T., Scaglia, L., & Bonner‐Weir, S. (1995) · Diabetes · doi:10.2337/diab.44.3.249 · Cited by 604 · see citing works

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

Kovacsovics-Bankowski, M., Clark, K., D, B. B. M., & Rock, K. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4942 · Cited by 590 · see citing works

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

Sigal, L. J., Crotty, S., Andino, R., & Rock, K. L. (1999) · Nature · doi:10.1038/18038 · Cited by 579 · see citing works

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

Porgador, A., Irvine, K. R., Iwasaki, A., Barber, B. H., Restifo, N. P., & Germain, R. N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1075 · Cited by 560 · see citing works

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

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CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

Yang, Y., & Wilson, J. M. (1996) · Science · doi:10.1126/science.273.5283.1862 · Cited by 433 · see citing works

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

Grewal, I. S., Foellmer, H. G., Grewal, K. D., Xu, J., Hardardottir, F., Baron, J. L., Janeway, C. A., & Flavell, R. A. (1996) · Science · doi:10.1126/science.273.5283.1864 · Cited by 418 · see citing works

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat

Scaglia, L., Cahill, C. J., Finegood, D. T., & Bonner‐Weir, S. (1997) · Endocrinology · doi:10.1210/endo.138.4.5069 · Cited by 418 · see citing works

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

Norbury, C. C., Hewlett, L. J., Prescott, A. R., Shastri, N., & Watts, C. K. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90067-5 · Cited by 410 · see citing works

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

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Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

Höglund, P., Mintern, J. D., Waltzinger, C., Heath, W. R., Benoist, C. O., & Mathis, D. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.331 · Cited by 406 · see citing works

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

Harding, C. V., & Song, R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.11.4925 · Cited by 385 · see citing works

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

Norbury, C. C., Chambers, B. J., Prescott, A. R., Ljunggren, H., & Watts, C. K. W. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270141 · Cited by 350 · see citing works

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

Udono, H., Levey, D. L., & Srivastava, P. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3077 · Cited by 347 · see citing works

Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.

Doe, B., Selby, M., Barnett, S. J., Baenziger, J., & Walker, C. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8578 · Cited by 340 · see citing works

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

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An ancient system of host defense

Medzhitov, R., & Janeway, C. A. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80024-1 · Cited by 327 · see citing works

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

Kurts, C., Miller, J. F. A. P., Subramaniam, R. M., Carbone, F., & Heath, W. R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.409 · Cited by 309 · see citing works

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

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Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

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Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

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CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

Adler, A. J., Marsh, D. W., Yochum, G. S., Guzzo, J. L., Nigam, A., Nelson, W. G., & Pardoll, D. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1555 · Cited by 294 · see citing works

Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

Ronchetti, A. B., Rovere, P. Q., Iezzi, G., Galati, G., Heltai, S., Protti, M. P., Garancini, M. P., Manfredi, A. A., Rugarli, C., & Bellone, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.130 · Cited by 293 · see citing works

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

Trudeau, J. D., Dutz, J. P., Arany, E. J., Hill, D. J., Fieldus, W. E., & Finegood, D. T. (2000) · Diabetes · doi:10.2337/diabetes.49.1.1 · Cited by 290 · see citing works

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines

Yewdell, J. W., Norbury, C. C., & Bennink, J. R. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60785-3 · Cited by 285 · see citing works

Processing of engulfed apoptotic bodies yields T cell epitopes

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

Kurts, C., Sutherland, R. M., Davey, G. M., Li, M., Lew, A. M., Blanas, E., Carbone, F., Miller, J. F. A. P., & Heath, W. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12703 · Cited by 245 · see citing works

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

Huang, A. Y.-C., Bruce, A. T., Pardoll, D. M., & Levitsky, H. I. (1996) · Immunity · doi:10.1016/s1074-7613(00)80248-4 · Cited by 224 · see citing works

Apoptosis in the Pancreatic Islet Cells of the Neonatal Rat Is Associated with a Reduced Expression of Insulin-Like Growth Factor II that May Act as a Survival Factor

Petrik, J., Arany, E. J., McDonald, T. J., & Hill, D. J. (1998) · Endocrinology · doi:10.1210/endo.139.6.6042 · Cited by 211 · see citing works

Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens

Heath, W. R., Kurts, C., Miller, J. F. A. P., & Carbone, F. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1549 · Cited by 209 · see citing works

Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes

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A fail-safe mechanism for maintaining self-tolerance.

Guerder, S., & Matzinger, P. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.553 · Cited by 205 · see citing works

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

Lu, Z., Yuan, L., Zhou, X., Sotomayor, E. M., Levitsky, H. I., & Pardoll, D. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.541 · Cited by 196 · see citing works

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

Chiodoni, C., Paglia, P., Stoppacciaro, A., Rodolfo, M., Parenza, M., & Colombo, M. P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.1.125 · Cited by 175 · see citing works

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

Pederson, R. A., Satkunarajah, M., McIntosh, C. H. S., Scrocchi, L. A., Flamez, D., Schuit, F. C., Drucker, D. J., & Wheeler, M. B. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1046 · Cited by 167 · see citing works

Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism

Josien, R., Heslan, M., Soulillou, J., & Cuturi, M. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.3.467 · Cited by 152 · see citing works

Macrophages as accessory cells for class I MHC-restricted immune responses

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CD8+ T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo

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Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice

Andrew, D. P., Spellberg, J. P., Takimoto, H., Schmits, R., Mak, T. W., & Zukowski, M. M. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199806)28:06 · Cited by 124 · see citing works

The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity

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Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake.

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Ontogeny of T cell tolerance to peripherally expressed antigens

Morgan, D. J. W., Kurts, C., Kreuwel, H. T. C., Holst, K. L., Heath, W. R., & Sherman, L. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3854 · Cited by 105 · see citing works

Cytotoxic T lymphocyte activation by cross-priming

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Priming MHC-I-Restricted Cytotoxic T Lymphocyte Responses to Exogenous Hepatitis B Surface Antigen Is CD4+ T Cell Dependent

Wild, J., Grusby, M. J., Schirmbeck, R., & Reimann, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1880 · Cited by 100 · see citing works

MHC Class I-Restricted Cytotoxic Lymphocyte Responses Induced by Enterotoxin-Based Mucosal Adjuvants

Simmons, C. P., Mastroeni, P., Fowler, R., Ghaem–Maghami, M., Lycke, N. Y., Pizza, M., Rappuoli, R., & Gordon Dougan, B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6502 · Cited by 97 · see citing works

H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes.

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Cooperation between Helper T Cells and Cytotoxic T Lymphocyte Precursors

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Peripheral tolerance of CD4 T cells following local activation in adolescent mice

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Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8+ T Cells

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Linked Recognition of Helper and Cytotoxic Antigenic Determinants for the Generation of Cytotoxic T Lymphocytesa

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Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.

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Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ

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Expression and Localization of the Annexins II, V, and VI in Myocardium from Patients with End-Stage Heart Failure

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Generation of Tumor-Specific Cytotoxic T Lymphocytes and Memory T Cells by Immunization with Tumor-Derived Heat Shock Protein gp96

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IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells

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