Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties
Abstract
Catalytic conversion of hydrogen peroxide (H 2 O 2 ) to more toxic hydroxyl radicals ( • OH) is a good choice for sterilization and anti-infection, but endogenous H 2 O 2 is insufficient to achieve satisfactory sterilization efficacy. Despite great efforts, designing and developing antimicrobial materials that specifically and effectively self-supply H 2 O 2 at the wound site remain as tremendous challenges. Here, we report a pH-responsive copper peroxide-loaded wound dressing made from copper hydroxide and gelatin sponge and then reacted with H 2 O 2 . In vitro experiments show that the prepared wound dressing has good bactericidal properties against Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ), and Pseudomonas aeruginosa ( P. aeruginosa ). Moreover, the as-prepared wound dressing can release • OH specifically in the bacterial-infected skin wound, rather than in normal tissues, and in vivo skin wound-healing experiments proved that the synthesized copper peroxide-loaded gelatin sponge could combat E. coli effectively; in addition, Cu 2+ released from the gelatin sponge could stimulate angiogenesis and collagen deposition simultaneously. The study provides a strategy to improve antibacterial efficacy and reduce the toxic side effects through the release of • OH by bacterial self-activation.
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Copper-containing biomaterials promote healing of infected wounds, including MRSA and Escherichia coli biofilm.
“Additionally, copper-containing biomaterials, mostly wound dressings, have shown significant potential in promoting the healing of infected wounds [68,87,91,92,93,94,95,96,97,98], including those infected with MRSA [99] and Escherichia coli biofilm [100].”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [94]
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Self-citation
- Authors
- Cui, H., Liu, M., Yu, W., Cao, Y., Zhou, H., Yin, J., Liu, H., Que, S., Wang, J., Huang, C., Gong, C., & Zhao, G.
- Affiliations
- Luoyang Ship Material Research Institute (CN)
- Lanzhou University (CN)
- Lanzhou University Second Hospital (CN)
- Qinghai Normal University (CN)
- Corresponding author
- Zhao, Guanghui
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-06-07
- Volume
- 13
- Issue
- 23
- Pages
- 26800-26807
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3168049017
- Cited by
- 116
- References
- 47
- Citations by year
- 2026: 9 · 2025: 25 · 2024: 28 · 2023: 29 · 2022: 20 · 2021: 5
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Funders
- State Key Laboratory For Marine Corrosion and Protection, Luoyang Ship Material Research Institute (KF190401)
- National Natural Science Foundation of China (21772080)
- Natural Science Foundation of Gansu Province (20JR10RA439)
- Natural Science Foundation of Qinghai Province (2021-ZJ-711)
- Science and Technology Program of Gansu Administration for Market Regulation (SSCJG-SP-201919)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- copper peroxide, gelatin sponge, wound dressings, hydrogen peroxide, hydroxyl radicals, antibacterial materials, pH-responsive drug release, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, skin wound healing, angiogenesis, collagen deposition, copper ion release
- MeSH terms
- Animals, Anti-Bacterial Agents, Bandages, Copper, Escherichia coli, Escherichia coli Infections, Gelatin, Mice, Inbred BALB C, Peroxides, Skin, Wound Healing, Wound Infection, Mice
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