Urchin-like Fe 3 O 4 @Bi 2 S 3 Nanospheres Enable the Destruction of Biofilm and Efficiently Antibacterial Activities
Abstract
Biofilm-associated infections (BAIs) have been considered a major threat to public health, which induce persistent infections and serious complications. The poor penetration of antibacterial agents in biofilm significantly limits the efficiency of combating BAIs. Magnetic urchin-like core–shell nanospheres of Fe 3 O 4 @Bi 2 S 3 were developed for physically destructing biofilm and inducing bacterial eradication via reactive oxygen species (ROS) generation and innate immunity regulation. The urchin-like magnetic nanospheres with sharp edges of Fe 3 O 4 @Bi 2 S 3 exhibited propeller-like rotation to physically destroy biofilm under a rotating magnetic field (RMF). The mild magnetic hyperthermia improved the generation of ROS and enhanced bacterial eradication. Significantly, the urchin-like nanostructure and generated ROS could stimulate macrophage polarization toward the M1 phenotype, which could eradicate the persistent bacteria with a metabolic inactivity state through phagocytosis, thereby promoting the recovery of implant infection and inhibiting recurrence. Thus, the design of magnetic-driven sharp-shaped nanostructures of Fe 3 O 4 @Bi 2 S 3 provided enormous potential in combating biofilm infections.
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Fe3O4-based nanozymes are known to catalyze ROS generation via Fenton-like reactions or directly release Fe2+/Fe3+ ions, thereby facilitating macrophage recruitment and M1 polarization.
“These nanozymes are known to catalyze ROS generation via Fenton-like reactions or directly release Fe2+/Fe3+ ions, thereby facilitating macrophage recruitment and M1 polarization [53].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [53]
Cites
Implant infections: adhesion, biofilm formation and immune evasion
Arciola, C. R., Campoccia, D., & Montanaro, L. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0019-y · Cited by 2,264 · see citing works
Monodisperse Magnetic Single‐Crystal Ferrite Microspheres
Deng, H., Li, X., Peng, Q., et al. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462551 · Cited by 2,014 · see citing works
The biofilm life cycle: expanding the conceptual model of biofilm formation
Sauer, K., Stoodley, P., Goeres, D. M., Hall‐Stoodley, L., Burmølle, M., Stewart, P. S., & Bjarnsholt, T. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00767-0 · Cited by 1,435 · see citing works
Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections
Makabenta, J. M., Nabawy, A. M., Li, C.-H., Schmidt-Malan, S. M., Patel, R., & Rotello, V. M. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0420-1 · Cited by 1,414 · see citing works
Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections
Huo, J., Jia, Q., Huang, H., Zhang, J., Li, P., Dong, X., & Huang, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00074h · Cited by 848 · see citing works
Enzyme Mimicry for Combating Bacteria and Biofilms
Chen, Z., Wang, Z., Ren, J., et al. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00011 · Cited by 499 · see citing works
Antibacterial Liquid Metals: Biofilm Treatment <i>via</i> Magnetic Activation
Elbourne, A., Cheeseman, S., Atkin, P., Truong, N. P., Syed, N., Zavabeti, A., Mohiuddin, M., Esrafilzadeh, D., Cozzolino, D., McConville, C. F., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b07861 · Cited by 302 · see citing works
Xiu, W., Wan, L., Yang, K., Li, X., Yuwen, L., Dong, H., Mou, Y., Yang, D., & Wang, L. (2022) · Nature Communications · doi:10.1038/s41467-022-31479-x · Cited by 292 · see citing works
Mei, J., Xu, D., Wang, L., Kong, L., Liu, Q., Li, Q., Zhang, X., Su, Z., Hu, X., Zhu, W., et al. (2023) · Advanced Materials · doi:10.1002/adma.202303432 · Cited by 280 · see citing works
Wang, P., Geng, J., Gao, J., Zhao, H., Li, J., Shi, Y., Yang, B., Chen, X., Linghu, Y., Sun, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08680-6 · Cited by 265 · see citing works
Zhu, W., Mei, J., Zhang, X., Zhou, J. Y., Xu, D., Su, Z., Fang, S., Wang, J., Zhang, X., & Zhu, C. (2022) · Advanced Materials · doi:10.1002/adma.202207961 · Cited by 250 · see citing works
Physical activation of innate immunity by spiky particles
Wang, J., Chen, H., Hang, T., Yu, Y., Liu, G., He, G., Xiao, S., Yang, B., Yang, C., Liu, F., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0274-0 · Cited by 247 · see citing works
Chu, Z., Yang, J., Zheng, W., Sun, J., Wang, W., & Qian, H. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215049 · Cited by 232 · see citing works
Self-citationNanoparticles for Oral Biofilm Treatments
Benoit, D. S. W., Sims, K. R., & FRASER, D. D. (2019) · ACS Nano · doi:10.1021/acsnano.9b02816 · Cited by 231 · see citing works
Advances in the Sensing and Treatment of Wound Biofilms
Darvishi, S., Tavakoli, S., Kharaziha, M., Girault, H. H., Kaminski, C. F., & Mela, I. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202112218 · Cited by 203 · see citing works
Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection
Hu, Y., Ruan, X., Lv, X., Xu, Y., Wang, W., Cai, Y., Ding, M., Dong, H., Shao, J., Yang, D., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101602 · Cited by 196 · see citing works
Self-citationBiofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment
Su, Y., Yrastorza, J. T., Matis, M. P., Cusick, J., Zhao, S., Wang, G., & Xie, J. (2022) · Advanced Science · doi:10.1002/advs.202203291 · Cited by 185 · see citing works
Magnetic Microswarm Composed of Porous Nanocatalysts for Targeted Elimination of Biofilm Occlusion
Dong, Y., Wang, L., Yuan, K., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c10010 · Cited by 181 · see citing works
Microneedle Patch-Mediated Treatment of Bacterial Biofilms
Xu, J., Danehy, R., Cai, H., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02578 · Cited by 175 · see citing works
Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers
Lv, X., Wang, L., Mei, A., Xu, Y., Ruan, X., Wang, W., Shao, J., Yang, D., & Dong, X. (2022) · Small · doi:10.1002/smll.202206220 · Cited by 175 · see citing works
Self-citationYang, Y., Wu, X., Ma, L., et al. (2021) · Advanced Materials · doi:10.1002/adma.202005477 · Cited by 170 · see citing works
Han, H., Gao, Y., Chai, M., Zhang, X., Liu, S., Huang, Y., Jin, Q., Grzybowski, A. E., Ji, J., & Yao, K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.014 · Cited by 165 · see citing works
Magnetic Microswarm and Fluoroscopy‐Guided Platform for Biofilm Eradication in Biliary Stents
Sun, M., Chan, K. F., Zhang, Z., et al. (2022) · Advanced Materials · doi:10.1002/adma.202201888 · Cited by 164 · see citing works
Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms
Teirlinck, E., Xiong, R., Brans, T., Forier, K., Fraire, J., Van Acker, H., Matthijs, N., De Rycke, R., De Smedt, S. C., Coenye, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06884-w · Cited by 154 · see citing works
Cai, X., Tian, J., Zhu, J., Chen, J., Li, L., Yang, C., Chen, J., & Chen, D. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131919 · Cited by 153 · see citing works
Cao, C., Zhang, T., Yang, N., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00900-8 · Cited by 150 · see citing works
Ruan, J., Liu, H., Chen, B., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c01077 · Cited by 145 · see citing works
Self-citationHe, X., Hou, J., Sun, X., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202203964 · Cited by 143 · see citing works
Li, J., Zhang, K., Ruan, L., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01000 · Cited by 138 · see citing works
Chen, L., Peng, M., Zhou, J., et al. (2023) · Advanced Materials · doi:10.1002/adma.202301664 · Cited by 131 · see citing works
Wang, D., Cheng, D., Ji, L., Niu, L., Zhang, X., Cong, Y., Cao, R.-H., Zhou, L., Bai, F., Qiao, Z., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120386 · Cited by 130 · see citing works
Zhang, C., Li, D., Pei, P., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119835 · Cited by 129 · see citing works
Tan, P., Wu, C., Tang, Q., Wang, T., Zhou, C., Ding, Y., Fu, H., Xu, S., Feng, Y., Zhang, Y., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210766 · Cited by 121 · see citing works
Pangolin-inspired untethered magnetic robot for on-demand biomedical heating applications
Soon, R. H., Zhen, Y., Dogan, M. A., Dogan, N. O., Tiryaki, M. E., Karacakol, A. C., Aydın, A., Esmaeili-Dokht, P., & Sitti, M. (2023) · Nature Communications · doi:10.1038/s41467-023-38689-x · Cited by 120 · see citing works
Sun, Y., Qin, H., Yan, Z., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808222 · Cited by 119 · see citing works
Qiu, H., Pu, F., Liu, Z., Deng, Q., Sun, P., Ren, J., & Qu, X. (2019) · Small · doi:10.1002/smll.201902522 · Cited by 116 · see citing works
Yang, C., Luo, Y., Shen, H., Ge, M., Tang, J. L., Wang, Q., Lin, H., Shi, J., & Zhang, X. (2022) · Nature Communications · doi:10.1038/s41467-022-32405-x · Cited by 114 · see citing works
Wang, J., Wang, L., Pan, J., Zhao, J., Tang, J. L., Jiang, D., Hu, P., Jia, W., & Shi, J. (2021) · Advanced Science · doi:10.1002/advs.202004010 · Cited by 110 · see citing works
Quan, K., Zhang, Z., Chen, H., et al. (2019) · Small · doi:10.1002/smll.201902313 · Cited by 106 · see citing works
Chen, B., Zhang, C., Wang, W., Chu, Z., Zha, Z., He, X., Zhou, W., Liu, T., Wang, H., & Qian, H. (2020) · ACS Nano · doi:10.1021/acsnano.0c04370 · Cited by 106 · see citing works
Self-citationDong, H., Xiu, W., Wan, L., Li, Q., Zhang, Y., Ding, M., Shan, J., Yang, K., Teng, Z., Yuwen, L., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139839 · Cited by 99 · see citing works
Cheng, X., Pei, X., Xie, W., et al. (2022) · Small · doi:10.1002/smll.202200915 · Cited by 95 · see citing works
Davis, E. M., Bergmann, A., Zhan, C., Kuhlenbeck, H., & Cuenya, B. R. (2023) · Nature Communications · doi:10.1038/s41467-023-40461-0 · Cited by 94 · see citing works
Wang, D., Wang, H., Ji, L., Xu, M., Bai, B., Wan, X., Hou, D., Qiao, Z., Wang, H., & Zhang, J. (2021) · ACS Nano · doi:10.1021/acsnano.1c00772 · Cited by 91 · see citing works
Mayorga‐Martinez, C. C., Zelenka, J., Klíma, K., Kubáňová, M., Ruml, T., & Pumera, M. (2023) · Advanced Materials · doi:10.1002/adma.202300191 · Cited by 82 · see citing works
Yuan, X., Wang, L., Hu, M., Zhang, L., Chen, H., Zhang, D., Wang, Z., Li, T., Zhong, M., Xu, L., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107556 · Cited by 80 · see citing works
Self-citationYu, X., Zhao, J., Ma, X., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.142933 · Cited by 75 · see citing works
Kong, Q., Qi, M., Li, W., et al. (2023) · Small · doi:10.1002/smll.202302547 · Cited by 73 · see citing works
Anjum, M. M., Patel, K. K., Dehari, D., et al. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00795-4 · Cited by 70 · see citing works
Li, H., Zhang, J., Yang, L., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202212193 · Cited by 68 · see citing works
Hou, Z., Wu, Y., Xu, C., Reghu, S., Shang, Z., Chen, J., Pranantyo, D., Marimuth, K., De, P. P., Ng, O. T., et al. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00755 · Cited by 60 · see citing works
Zong, L., Yang, Y. L., Wang, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122074 · Cited by 60 · see citing works
Pettygrove, B. A., Kratofil, R. M., Alhede, M., Jensen, P. Ø., Newton, M., Qvortrup, K., Pallister, K. B., Bjarnsholt, T., Kubes, P., Voyich, J. M., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120775 · Cited by 57 · see citing works
Chen, X., Zhang, X., Lin, F., et al. (2019) · Small · doi:10.1002/smll.201901647 · Cited by 51 · see citing works
Albayaty, Y. N., Thomas, N., Jambhrunkar, M., Al‐Hawwas, M., Kral, A., Thorn, C. R., & Prestidge, C. A. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.05.069 · Cited by 46 · see citing works
Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
Torres‐Herrero, B., Armenia, I., Alleva, M., Asín, L., Correa, S., Ortiz, C., Fernández‐Afonso, Y., Gutiérrez, L., de la Fuente, J. M., Betancor, L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01599 · Cited by 45 · see citing works
Designer Liposomic Nanocarriers Are Effective Biofilm Eradicators
Kluzek, M., Oppenheimer‐Shaanan, Y., Dadosh, T., Morandi, M. I., Avinoam, O., Raanan, C., Goldsmith, M., Goldberg, R., & Klein, J. E. (2022) · ACS Nano · doi:10.1021/acsnano.2c04232 · Cited by 43 · see citing works
Chen, Q., Qi, M., Shi, F., Liu, C., Shi, Y., Sun, Y. L., Bai, X., Wang, L., Sun, X., Dong, B., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300313 · Cited by 43 · see citing works
Fang, J., Lin, Y., Wang, P., Alalaiwe, A. S., Yang, Y., & Yang, S.-C. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s221663 · Cited by 42 · see citing works
Li, R. S., Liu, J., Wen, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg9601 · Cited by 41 · see citing works
Wu, R., Yu, T., Liu, S., Shi, R., Jiang, G., Ren, Y., van der Mei, H. C., Busscher, H. J., & Liu, J. (2023) · ACS Nano · doi:10.1021/acsnano.2c09008 · Cited by 40 · see citing works
Designer co-beta-peptide copolymer selectively targets resistant and biofilm Gram-negative bacteria
Si, Z., Li, J., Ruan, L., Reghu, S., Ooi, Y. J., Li, P., Zhu, Y., Hammond, P. T., Verma, C. S., Bazan, G. C., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122004 · Cited by 39 · see citing works
A Magnetic Cloud Bomb for Effective Biofilm Eradication
Qian, Y., Zhang, L., Li, N., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214330 · Cited by 39 · see citing works
GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms
Piao, Y., Qi, Y., Hu, X., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.013 · Cited by 31 · see citing works
Xu, C., Liu, Y., Li, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202204996 · Cited by 31 · see citing works
Zhang, J., Wang, W., Zhao, M., et al. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b01413 · Cited by 29 · see citing works
Self-citationLi, Q., Liu, Q., Wang, Z., et al. (2023) · Small · doi:10.1002/smll.202300592 · Cited by 28 · see citing works
Yang, Y., Mao, X., Li, R., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202210265 · Cited by 12 · see citing works
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Wu, Y., Cai, Z., Zhang, Y., Zheng, Y., Liao, L., & Jia, Z. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.018 · Cited by 7 · see citing works
- Authors
- Xu, Y., Chen, B., Xu, L., Zhang, G., Cao, L., Liu, N., Wang, W., Qian, H., & Shao, M.
- Affiliations
- Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui, P. R. China
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Corresponding author
- Wang, Wanni
- Qian, Haisheng
- Shao, Min
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2024-01-11
- Volume
- 16
- Issue
- 3
- Pages
- 3215-3231
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W4390740934
- Cited by
- 35
- References
- 68
- Citations by year
- 2026: 6 · 2025: 23 · 2024: 6
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Anhui Provincial Department of Education (2023AH053300)
- Anhui University (KJ2021ZD0023)
- National Natural Science Foundation of China (52172276, U20A20379)
- University and Hospital Joint Discipline Construction Project (2021lcxk019)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
- Keywords
- urchin-like nanostructures, biofilm eradication, biofilm-associated infections, antibacterial activity, reactive oxygen species generation, magnetic hyperthermia, rotating magnetic field, macrophage polarization, M1 macrophage polarization, phagocytosis, implant-associated infection, persistent bacterial infection, magnetic nanoparticles
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Reactive Oxygen Species, Biofilms, Nanostructures, Nanospheres
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