The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats
Abstract
Currently, combining biomaterial scaffolds with living stem cells for tissue regeneration is a main approach for tissue engineering. Mesenchymal stem cells (MSCs) are promising candidates for musculoskeletal tissue repair through differentiating into specific tissues, such as bone, muscle, and cartilage. Thus, successfully directing the fate of MSCs through factors and inducers would improve regeneration efficiency. Here, we report the fabrication of graphene oxide (GO)-doped poly(lactic-co-glycolic acid) (PLGA) nanofiber scaffolds via electrospinning technique for the enhancement of osteogenic differentiation of MSCs. GO-PLGA nanofibrous mats with three-dimensional porous structure and smooth surface can be readily produced via an electrospinning technique. GO plays two roles in the nanofibrous mats: first, it enhances the hydrophilic performance, and protein- and inducer-adsorption ability of the nanofibers. Second, the incorporated GO accelerates the human MSCs (hMSCs) adhesion and proliferation versus pure PLGA nanofiber and induces the osteogenic differentiation. The incorporating GO scaffold materials may find applications in tissue engineering and other fields.
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Cites
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Cited by
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484
Lin, H., Sohn, J., Shen, H., Langhans, M. T., & Tuan, R. S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.026 · Cited by 445
Self-citationRecent advances in PLGA-based biomaterials for bone tissue regeneration
Jin, S., Xia, X., Huang, J., Yuan, C., Zuo, Y., Li, Y., & Li, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.067 · Cited by 295
Self-citationNourany, M., Makaremy, A., Bazrpash, S., & Hosseini, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140149 · Cited by 15
Metadata
- Authors
- Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., & Zhang, Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-03-12
- Volume
- 7
- Issue
- 11
- Pages
- 6331-6339
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2055926256
- Cited by
- 323
- References
- 53
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats. https://app.cochat.ai/papers/10.1021/acsami.5b00862
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- Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., & Zhang, Z. (2015). Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.5b00862
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