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Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles
Abstract
In this work, we synthesized pristine mesoporous silica nanoparticles (MSN) and functionalized these with phosphonate groups (MSN-Phos). We report, for the first time, cell death in MCF-7 cells (human breast adenocarcinoma cell line) when exposed to the empty MSN and MSN-Phos nanoparticles. In comparison, the same nanoparticles were found to elicit few deleterious effects on normal human foreskin fibroblast cells (BJ cells). MCF-7 cells were found to exhibit a concentration-dependent uptake, whereas no detectable nanoparticle uptake was observed in the BJ cells, irrespective of treatment dosage. A disruption of the cell cycle in the MCF-7 cells was determined to be the cause of cell death from the nanoparticle exposure, thereby suggesting the role of nondrug loaded MSN and MSN-Phos as effective anticancer drugs.
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In the citing paper
“As their surface was functionalized with phosphonate groups in MSNsP, we observed a new band at 953 cm−1 and a broad peak from 3000 to 3600 cm−1, reflecting phosphonate groups [39].”
From Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles (2020) · cites this paper as [39]
In the citing paper
“They mentioned that cancer cells uptake more MSNs than normal cells, and MSNs are more cytotoxic for cancer cells compared normal cells.”
From Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles (2020) · cites this paper as [39]
In the citing paper
“This finding agrees with previously published data for MCF-7 cells and BJ cells treated with MSNs and phosphonate-functionalized MSNs [39].”
From Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles (2020) · cites this paper as [39]
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Cited by
Sorted by citations
AbouAitah, K., Hassan, H. A., Swiderska-Sroda, A., Gohar, L., Shaker, O. G., Wojnarowicz, J., Opalinska, A., Smalc-Koziorowska, J., Gierlotka, S., & Lojkowski, W. (2020) · Cancers · doi:10.3390/cancers12010144 · Cited by 105
Metadata
- Authors
- Menon, N., & Leong, D. T.
- Affiliations
- Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-15
- Volume
- 8
- Issue
- 3
- Pages
- 2416-2422
- ISSN
- 1944-8244
- 1944-8252
- Cited by
- 22
- References
- 1
- Language
- en
- Funders
- Ministry of Education - Singapore (R279-000-418-112; MOE2013-T2-2-093)
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- CoChat. (2026). Citation check: Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles. https://app.cochat.ai/papers/10.1021/acsami.5b11741
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- Menon, N., & Leong, D. T. (2016). Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.5b11741
