MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery
Abstract
Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DLS showed its usefulness in defining micelles structural modifications in response to temperature, pH, enzymes, and light.
“Concerning stimuli-responsive micelles, DLS showed its usefulness in defining micelles structural modifications in response to temperature [141][142][143], pH [143,144], enzymes [145,146] and light [141,147].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [145]
DLS analysis confirmed the morphological changes resulting from micelles breakage induced by the enzymatic cleavage of the peptide linkage between doxorubicin and PLL in metalloproteinases-sensitive micelles.
“DLS analysis confirmed the morphological changes resulting from micelles breakage induced by the enzymatic cleavage of the peptide linkage between doxorubicin and PLL.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [145]
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Self-citationStimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Drug penetration in solid tumours
Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805 · see citing works
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270 · see citing works
Du, J., Du, X., Mao, C., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,177 · see citing works
Pan, L., He, Q., Liu, J., Chen, Y., Ma, M., Zhang, L., & Shi, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211035w · Cited by 985 · see citing works
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 917 · see citing works
Huang, P., Wang, D., Su, Y., Huang, W., Zhou, Y., Cui, D., Zhu, X., & Yan, D. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505212y · Cited by 720 · see citing works
Subcellular targeting strategies for drug design and delivery
Rajendran, L., Knölker, H., & Simons, K. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2897 · Cited by 709 · see citing works
Chu, Z., Dreiss, C. A., & Feng, Y. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35490c · Cited by 568 · see citing works
Design and development of polymeric micelles with cleavable links for intracellular drug delivery
Wei, H., Zhuo, R., & Zhang, X. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.07.002 · Cited by 475 · see citing works
Self-citationDai, J., Lin, S., Cheng, D., Zou, S., & Shuai, X. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103806 · Cited by 382 · see citing works
Matrix Metalloproteinases as Therapeutic Targets in Cancer
Vihinen, P., Ala‐aho, R., & Kähäri, V. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053765799 · Cited by 280 · see citing works
An Activatable Theranostic for Targeted Cancer Therapy and Imaging
Bhuniya, S., Maiti, S., Kim, E. J., Lee, H., Sessler, J. L., Hong, K. S., & Kim, J. S. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201311133 · Cited by 215 · see citing works
Polymeric micelles for drug targeting
Mahmud, A., Xiong, X.-B., Aliabadi, H. M., & Lavasanifar, A. (2007) · Journal of drug targeting · doi:10.1080/10611860701538586 · Cited by 201 · see citing works
Noncovalent interaction-assisted polymeric micelles for controlled drug delivery
Ding, J., Chen, L., Xiao, C., Chen, L., Zhuang, X., & Chen, X. (2014) · Chemical Communications · doi:10.1039/c4cc03153a · Cited by 188 · see citing works
Sharma, P., & Garg, S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.019 · Cited by 165 · see citing works
Redox-sensitive shell cross-linked PEG–polypeptide hybrid micelles for controlled drug release
Wang, K., Luo, G., Liu, Y., Li, C., Cheng, S., Zhuo, R., & Zhang, X. (2012) · Polymer Chemistry · doi:10.1039/c2py00600f · Cited by 114 · see citing works
Self-citationStructural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases
Aureli, L., Gioia, M., Cerbara, I., Monaco, S., Fasciglione, G. F., Marini, S., Ascenzi, P., Topai, A., & Coletta, M. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785747490 · Cited by 101 · see citing works
Chen, W., Xu, X., Luo, G., Jia, H.-Z., Lei, Q., Cheng, S., Zhuo, R., & Zhang, X. (2013) · Scientific Reports · doi:10.1038/srep03468 · Cited by 97 · see citing works
Self-citationPolymeric micelles with stimuli-triggering systems for advanced cancer drug targeting
Nakayama, M., Akimoto, J., & Okano, T. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.936872 · Cited by 90 · see citing works
Zou, Y., Song, Y., Yang, W., Meng, F., Liu, H., & Zhong, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.016 · Cited by 86 · see citing works
Yang, B., Lv, Y., Zhu, J., Han, Y., Jia, H.-Z., Chen, W.-H., Feng, J. X., Zhang, X., & Zhuo, R. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.05.018 · Cited by 72 · see citing works
Self-citationCombinatorial Nanoparticles for Cancer Diagnosis and Therapy
Mukerjee, A., Ranjan, A. P., & Vishwanatha, J. K. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801661176 · Cited by 63 · see citing works
Xu, W., Burke, J. F., Pilla, S., Chen, H., Jaskula‐Sztul, R., & Gong, S. (2013) · Nanoscale · doi:10.1039/c3nr03102k · Cited by 44 · see citing works
Dual-targeting delivery system for selective cancer cell death and imaging
Tian, X., Baek, K. H., & Shin, I. (2012) · Chemical Science · doi:10.1039/c2sc21777e · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis
Das, S. S., Bharadwaj, P., Bilal, M., Barani, M., Rahdar, A., Taboada, P., BUNGAU, S. G., & Kyzas, G. Z. (2020) · Polymers · doi:10.3390/polym12061397 · Cited by 607 · see citing works
Drug self-delivery systems for cancer therapy
Qin, S.-Y., Zhang, A.-Q., Cheng, S.-X., Rong, L., & Zhang, X.-Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.016 · Cited by 532 · see citing works
Self-citationEl‐Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El‐Say, K. M., & Torchilin, V. P. (2018) · ACS Nano · doi:10.1021/acsnano.8b06104 · Cited by 435 · see citing works
Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
Zhou, Q., Zhang, L., Yang, T., & Wu, H. Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s158696 · Cited by 415 · see citing works
Stimuli-responsive nanoparticles for targeting the tumor microenvironment
Du, J., Lane, L. A., & Nie, S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.050 · Cited by 385 · see citing works
Ramasamy, T., Ruttala, H. B., Gupta, B., Poudel, B. K., Choi, H., Yong, C. S., & Kim, J. O. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.043 · Cited by 373 · see citing works
Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics
Gong, F., Yang, N., Wang, X., Zhao, Q., Chen, Q., Liu, Z., & Cheng, L. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100851 · Cited by 365 · see citing works
Ligand-installed nanocarriers toward precision therapy
Mi, P., Cabral, H., & Kataoka, K. (2020) · Advanced Materials · doi:10.1002/adma.201902604 · Cited by 350 · see citing works
Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment
Chen, B., Dai, W., He, B., Zhang, H., Wang, X., Wang, Y., & Zhang, Q. (2017) · Theranostics · doi:10.7150/thno.16684 · Cited by 347 · see citing works
Sultana, A., Zare, M., Thomas, V., Kumar, T. S. S., & Ramakrishna, S. (2022) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2022.100134 · Cited by 321 · see citing works
Song, Y., Li, Y., Xu, Q., & Liu, Z. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s117495 · Cited by 262 · see citing works
Jia, X., Zhang, Y., Zou, Y., Wang, Y., Niu, D., He, Q., Huang, Z., Zhu, W., Tian, H., Shi, J., et al. (2018) · Advanced Materials · doi:10.1002/adma.201704490 · Cited by 232 · see citing works
Stimulus-cleavable chemistry in the field of controlled drug delivery
Xue, Y., Bai, H., Peng, B., Fang, B., Baell, J. B., Li, L., Huang, W., & Voelcker, N. H. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01061h · Cited by 176 · see citing works
Biotin conjugated organic molecules and proteins for cancer therapy: A review
Maiti, S., & Paira, P. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.001 · Cited by 157 · see citing works
Chen, W., Luo, G., Lei, Q., Cao, F., Fan, J., Qiu, W., Jia, H.-Z., Hong, S., Fang, F., Zeng, X., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.053 · Cited by 149 · see citing works
Self-citationCarrier-free nanomedicines for cancer treatment
Liu, L., & Zhang, X. (2022) · Progress in Materials Science · doi:10.1016/j.pmatsci.2021.100919 · Cited by 133 · see citing works
Self-citationLiu, L., Qiu, W., Zhang, Y., Li, B., Zhang, C., Gao, F., Zhang, L., & Zhang, X. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700220 · Cited by 130 · see citing works
Self-citationRecent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines
Qin, S., Zhang, A., & Zhang, X. (2018) · Small · doi:10.1002/smll.201802417 · Cited by 131 · see citing works
Self-citationZwitterionic Phosphorylcholine–TPE Conjugate for pH-Responsive Drug Delivery and AIE Active Imaging
Chen, Y., Han, H., Tong, H., Chen, T., Wang, H., Ji, J., & Jin, Q. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06071 · Cited by 121 · see citing works
Smart linkers in polymer–drug conjugates for tumor-targeted delivery
Chang, M., Zhang, F., Wei, T., Zuo, T., Guan, Y., Lin, G., & Shao, W. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1108324 · Cited by 107 · see citing works
Zou, Z., He, X., He, D., Wang, K., Qing, Z., Yang, X., Wen, L., Xiong, J. J., Li, L., & Cai, L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.034 · Cited by 100 · see citing works
Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems
van Elk, M., Murphy, B. P., Eufrásio-da-Silva, T., O’Reilly, D. P., Vermonden, T., Hennink, W. E., Duffy, G. P., & Ruiz‐Hernández, E. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.10.013 · Cited by 97 · see citing works
“Smart” drug delivery: A window to future of translational medicine
Rana, A., Adhikary, M., Singh, P. K., Das, B. C., & Bhatnagar, S. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1095598 · Cited by 104 · see citing works
Tsai, L., Hsieh, H., Lu, K.-Y., Wang, S.-Y., & Mi, F. (2015) · Nanomedicine · doi:10.2217/nnm.15.183 · Cited by 94 · see citing works
Cheng, Y., Huang, F., Min, X., Gao, P., Zhang, T., Li, X., Liu, B., Hong, Y., Lou, X., & Xia, F. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02833 · Cited by 94 · see citing works
Glyco-nanoparticles: New drug delivery systems in cancer therapy
Khan, H. Z., Mirzaei, H. R., Amiri, A., Akkol, E. K., Halimi, S. M. A., & Mirzaei, H. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.004 · Cited by 88 · see citing works
Zhu, J., Amili, M. A., & Guo, S. (2024) · Biomedicines · doi:10.3390/biomedicines12020417 · Cited by 90 · see citing works
Gawade, P. M., Shadish, J. A., Badeau, B. A., & DeForest, C. A. (2019) · Advanced Materials · doi:10.1002/adma.201902462 · Cited by 86 · see citing works
Wang, X., Lei, Q., Zhu, J., Wang, W., Qian, C., Gao, F., Sun, Y., & Zhang, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b07507 · Cited by 83 · see citing works
Self-citationZhang, Z.-T., Huang-Fu, M.-Y., Xu, W.-H., & Han, M. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.02.009 · Cited by 82 · see citing works
Self-delivery of a peptide-based prodrug for tumor-targeting therapy
Peng, M., Qin, S., Jia, H., Zheng, D., Rong, L., & Zhang, X. (2015) · Nano Research · doi:10.1007/s12274-015-0945-1 · Cited by 81 · see citing works
Self-citationMelnyk, T., Đorđević, S., Conejos‐Sánchez, I., & Vicent, M. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.007 · Cited by 80 · see citing works
Wu, J., Han, H., Jin, Q., Li, Z., Li, H., & Ji, J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b15853 · Cited by 79 · see citing works
Aleandri, S., Bandera, D., Mezzenga, R., & Landau, E. M. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b03469 · Cited by 79 · see citing works
Hou, S., Chen, S., Dong, Y., Gao, S., Zhu, B., & Lu, Q. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b06114 · Cited by 79 · see citing works
Multifunctional Theranostic Nanoplatform for Cancer Combined Therapy Based on Gold Nanorods
Chen, W., Yang, C., Qiu, W., Luo, G., Jia, H., Lei, Q., Wang, X., Liu, G., Zhuo, R., & Zhang, X. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500453 · Cited by 78 · see citing works
Self-citationMatrix Metalloproteinase-Responsive Drug Delivery Systems
Zhang, C., Jiang, G., & Gao, X. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00266 · Cited by 69 · see citing works
Polymeric functionalization of mesoporous silica nanoparticles: Biomedical insights
Nair, A., Hariharapura, R. C., Day, C. M., Garg, S., Nayak, Y., Shenoy, P. A., & Nayak, U. Y. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124314 · Cited by 69 · see citing works
Xiong, D., Zhang, X., Peng, S., Gu, H., & Zhang, L. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.12.008 · Cited by 66 · see citing works
Self-citationWu, M., Li, J., Lin, X., Wei, Z., Zhang, D., Zhao, B., Liu, X., & Liu, J. (2018) · Biomaterials Science · doi:10.1039/c8bm00226f · Cited by 61 · see citing works
Antimicrobial peptide-modified silver nanoparticles for enhancing the antibacterial efficacy
Li, W., Li, Y., Sun, P., Zhang, N., Zhao, Y. D., Qin, S., & Zhao, Y. (2020) · RSC Advances · doi:10.1039/d0ra05640e · Cited by 59 · see citing works
Enzyme sensitive, surface engineered nanoparticles for enhanced delivery of camptothecin
Yu, H., Chen, J., Liu, S., Lu, Q., He, J., Zhou, Z., & Hu, Y. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.021 · Cited by 57 · see citing works
Zhou, J., Wang, M., Ying, H., Su, D., Zhang, H., Lu, G., & Chen, J. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00327 · Cited by 57 · see citing works
Zong, L., Xu, H., Zhang, H., Tu, Z., Zhang, X., Wang, S., Li, M., Feng, Y., Wang, B., Li, L., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130043 · Cited by 55 · see citing works
Self-citationEskandari, P., Bigdeli, B., Daryasari, M. P., Baharifar, H., Bazri, B., Shourian, M., Amani, A., Sadighi, A., Goliaei, B., Khoobi, M., et al. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1599379 · Cited by 54 · see citing works
Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy
Li, Y., Zhang, C., Li, G., Deng, G., Zhang, H., Sun, Y., & An, F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.017 · Cited by 52 · see citing works
Biomedical applications of functional peptides in nano-systems
Rong, L., Qin, S., Zhang, C., Cheng, Y., Feng, J. X., Wang, S., & Zhang, X. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.06.001 · Cited by 50 · see citing works
Self-citationHu, Y., Gong, X. N., Zhang, J., Chen, F., Fu, C., Li, P., Zou, L., & Zhao, G. (2016) · Polymers · doi:10.3390/polym8040099 · Cited by 45 · see citing works
Cheng, H. B., Li, S., Zheng, H., Li, C., Xie, B., Chen, K.-W., Li, B., & Zhang, X. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00277 · Cited by 43 · see citing works
Self-citationEncapsulation and release of drug nanoparticles in functional polymeric vesicles
Jia, L., Wang, R., & Fan, Y. (2020) · Soft Matter · doi:10.1039/d0sm00069h · Cited by 41 · see citing works
Biodegradable nanomaterials for diagnosis and therapy of tumors
Cao, D., Chen, L., Zhang, Z., Luo, Y., Zhao, L., Yuan, C., Lü, J., Liu, X., & Li, J. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02591d · Cited by 40 · see citing works
Endogenous stimuli-responsive linkers in nanoliposomal systems for cancer drug targeting
Maleki, M. F., Jafari, A., Mirhadi, E., Askarizadeh, A., Golichenari, B., Hadizadeh, F., Moghimi, S. M. J., Aryan, R., Mashreghi, M., & Jaafari, M. R. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118716 · Cited by 40 · see citing works
Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy
Han, H., Jin, Q., Wang, H., Teng, W., Wu, J., Tong, H., Chen, T., & Ji, J. (2016) · Small · doi:10.1002/smll.201600950 · Cited by 38 · see citing works
Polyamino acid-based gemcitabine nanocarriers for targeted intracellular drug delivery
Teng, W., Jia, F., Han, H., Qin, Z., Jin, Q., & Ji, J. (2017) · Polymer Chemistry · doi:10.1039/c7py00443e · Cited by 37 · see citing works
Birhan, Y. S., & Tsai, H. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01253c · Cited by 38 · see citing works
Khan, S., Vahdani, Y., Hussain, A., Haghighat, S., Heidari, F., Nouri, M., Bloukh, S. H., Edis, Z., Babadaei, M. M. N., Ale‐Ebrahim, M., et al. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103264 · Cited by 35 · see citing works
Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment
Xiong, J., & Gao, H. (2017) · Journal of Microencapsulation · doi:10.1080/02652048.2017.1343873 · Cited by 34 · see citing works
Wu, J., Yuan, J., Ye, B., Wu, Y., Xu, Z., Chen, J., & Chen, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00663 · Cited by 33 · see citing works
Kong, L., Zhang, S., Chu, J.-H., Liu, X., Zhang, L., He, S.-Y., Yang, S., Ju, R.-J., & Li, X. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s258906 · Cited by 33 · see citing works
Sahu, B. P., Baishya, R., Hatiboruah, J. L., Laloo, D., & Biswas, N. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00583-x · Cited by 31 · see citing works
Ni, R., Zhu, J., Xu, Z., & Chen, Y. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02264c · Cited by 29 · see citing works
Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles
Pan, J., Li, P.-J., Wang, Y., Chang, L., Wan, D., & Wang, H. (2018) · Chemical Communications · doi:10.1039/c8cc05504a · Cited by 28 · see citing works
El-Nablaway, M., Rashed, F., Taher, E. S., Foda, T., Abdeen, A., Abdo, M., Fericean, L. M., Bănățean-Dunea, I., Mihaela, O., Dinu, Ş., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122671 · Cited by 27 · see citing works
Price, D. J., Khuphe, M., Davies, R. P., McLaughlan, J. R., Ingram, N., & Thornton, P. D. (2017) · Chemical Communications · doi:10.1039/c7cc04504b · Cited by 27 · see citing works
Matrix metalloproteinase-triggered self-assembling peptides for biomedical applications
Liu, Z., Yu, C., Li, Z., Wang, X., Shang, D., & Dong, W. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00625b · Cited by 26 · see citing works
Zhou, H., Sun, H., Lv, S., Zhang, D., Zhang, X., Tang, Z., & Chen, X. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.03.019 · Cited by 26 · see citing works
Self-citationLuo, S. J., Zhang, Y., Cao, J., He, B., & Li, S. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.07.023 · Cited by 25 · see citing works
Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy
Tarassoli, S. P., Bayona, A. M. D. P., Pye, H., Mosse, C. A., Callan, J. F., MacRobert, A. J., McHale, A. P., & Nomikou, N. (2016) · Nanotechnology · doi:10.1088/1361-6528/28/5/055101 · Cited by 25 · see citing works
Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles
Menon, N., & Leong, D. T. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b11741 · Cited by 24 · see citing works
Chen, Y., Wang, Y., Wang, H., Jia, F., Cai, T., Ji, J., & Jin, Q. (2016) · Polymer · doi:10.1016/j.polymer.2016.05.051 · Cited by 24 · see citing works
Anticancer nanomedicines harnessing tumor microenvironmental components
Li, Y., Chen, Z., Gu, L., Duan, Z., Pan, D., Xu, Z., Gong, Q., Li, Y., Zhu, H., & Luo, K. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2050211 · Cited by 23 · see citing works
Cheng, Y., Zou, T., Dai, M., He, X., Peng, N., Wu, K., Wang, X., Liao, C.-Y., & Liu, Y. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.03.002 · Cited by 23 · see citing works
Yang, C., Pang, X., Chen, W., Wang, X., Lin, G., Chu, C., Zhang, X., Deng, X., Chen, X. S., & Liu, G. (2019) · 中国科学通报:英文版 · doi:10.1016/j.scib.2019.04.019 · Cited by 23 · see citing works
Self-citationGuo, Y., Li, S., Liu, J., Yang, G., Sun, Z., & Wan, J. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.05.131 · Cited by 20 · see citing works
Theranostic applications of smart nanomedicines for tumor-targeted chemotherapy: a review
Juthi, A. Z., Aquib, M., Farooq, M. A., Ghayas, S., Khalid, F., Boafo, G. F., Wande, D. P., Khan, D. H., Bithi, T. Z., Bavi, R., et al. (2020) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01031-8 · Cited by 21 · see citing works
Preparation of poly(cyclotriphosphazene-co-piperazine) nanospheres and their drug release behavior
Mehmood, S., Wang, L., Yu, H., Haq, F., Amin, B.-U., Uddin, M. A., Fahad, S., Haroon, M., Shen, D., & Ni, Z. (2020) · International Journal of Polymeric Materials · doi:10.1080/00914037.2020.1809407 · Cited by 20 · see citing works
Strategies to release doxorubicin from doxorubicin delivery vehicles
Li, J., Zhang, B., Yue, C., Wu, J., Zhao, L., Sun, D., & Wang, R. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1363209 · Cited by 20 · see citing works
Baohai, X., Shi, F., & Yongqi, F. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108946 · Cited by 18 · see citing works
Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy
Liang, S., Wang, M., Wang, J., & Chen, G. (2021) · ChemBioChem · doi:10.1002/cbic.202100313 · Cited by 18 · see citing works
Yang, J., Wang, R., & Xie, D. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b01172 · Cited by 18 · see citing works
Jiang, W., Gao, Y., Wang, Z., Gong, C., Hu, C., Ding, X., Qiang, L., Gao, S., & Ren, F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01074 · Cited by 17 · see citing works
Li, H., Liu, C., Xu, Q., Lu, C., Yang, G., Wang, F., Nie, J., Hu, X., Dong, N., & Shi, J. (2019) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2019.04.008 · Cited by 17 · see citing works
Cao, D., Liang, L., Xu, Y., Sun, J., Lei, M., Wang, M., Wei, Y., & Sun, Z. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.12.018 · Cited by 16 · see citing works
Alemayehu, Y. A., Fan, W.-L., Ilhami, F. B., Chiu, C., Lee, D., & Cheng, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134677 · Cited by 15 · see citing works
Raychaudhuri, R., Pandey, A., Hegde, A. R., Fayaz, S. M. A., Chellappan, D. K., Dua, K., & Mutalik, S. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1819237 · Cited by 15 · see citing works
Wu, H., Ding, X., Chen, Y., Cai, Y., Yang, Z., & Jin, J. (2023) · ACS Omega · doi:10.1021/acsomega.2c07949 · Cited by 14 · see citing works
Li, S., Li, T., Wang, X., Rahmatulla, A., Zhao, Y., Zhang, X., Liu, Y., & Chen, Y. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2514564 · Cited by 13 · see citing works
Self-citationKalosakas, G. (2023) · Materials · doi:10.3390/ma16134595 · Cited by 13 · see citing works
Chenab, K. K., Malektaj, H., Nadinlooie, A. A. R., Mohammadi, S., & Zamani-Meymian, M.-R. (2024) · Microchimica Acta · doi:10.1007/s00604-024-06583-y · Cited by 13 · see citing works
Mittal, A., & Chitkara, D. (2016) · Therapeutic Delivery · doi:10.4155/tde.15.90 · Cited by 13 · see citing works
Enzyme-Responsive Polymeric Materials with Anticancer and Antibacterial Activities
Ghosh, D., Bag, S., & De, P. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01944 · Cited by 12 · see citing works
Akib, A. A., Shakil, R., Rumon, M. M. H., Roy, C. K., Chowdhury, E. H., & Chowdhury, A. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220506135301 · Cited by 12 · see citing works
Zhou, M., Yao, Y., Ma, S., Zou, M., Chen, Y., Cai, S., Zhao, F., Wu, H., Xiao, F., Abudushalamu, G., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125475 · Cited by 9 · see citing works
Wen, A., Mei, X., Feng, C., Shen, C., Wang, B., & Zhang, X. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110759 · Cited by 8 · see citing works
Self-citationWu, H., Ding, X., Chen, Y., Cai, Y., Yang, Z., & Jin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127538 · Cited by 7 · see citing works
Mehmood, S., Uddin, M. A., Yu, H., Wang, L., Amin, B. U., Haq, F., Fahad, S., & Haroon, M. (2022) · ChemistrySelect · doi:10.1002/slct.202200273 · Cited by 7 · see citing works
Enzyme-responsive Drug Delivery Systems
Secret, E., & Andrew, J. S. (2018) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013536-00209 · Cited by 6 · see citing works
Qu, L., Wang, J. H., Du, J., Kang, P., Niu, X., & Yin, L. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02522-4 · Cited by 6 · see citing works
Lei, J., Song, Y., Li, D., Lei, M., Tan, R., Liu, Y., & Zheng, H. S. (2021) · Journal of Applied Polymer Science · doi:10.1002/app.51535 · Cited by 5 · see citing works
- Authors
- Chen, W.-H., Luo, G.-F., Lei, Q., Jia, H.-Z., Hong, S., Wang, Q.-R., Zhuo, R.-X., & Zhang, X.-Z.
- Affiliations
- Wuhan University (CN)
- Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry
- Corresponding author
- Zhang, Xian-Zheng
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 51
- Issue
- 3
- Pages
- 465-468
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2164840927
- Cited by
- 115
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 16 · 2017: 11 · 2016: 15 · 2015: 9
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51125014 and 51233003)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymeric micelles, intracellular drug delivery, tumor targeting, receptor-mediated endocytosis, apoptosis, anticancer drug delivery
- MeSH terms
- Antineoplastic Agents, Cell Survival, Humans, Micelles, Models, Biological, Polymers, Drug Delivery Systems, Microscopy, Confocal, Matrix Metalloproteinase 2, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review