Cited by 115Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersAdvanced Drug Delivery Systems

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

Chen, Wei-Hai, Luo, Guo-Feng, Lei, Qi, Jia, Hui-Zhen, Hong, Sheng, Wang, Qing-Rong, Zhuo, Ren-Xi, Zhang, Xian-Zheng·2015·Chemical Communications

Abstract

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.

Integrity signals

Registry

Crossref · 10.1039/c4cc07563c

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27 of 27 references verified0 citation errors · 0 not checkable

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Authors
Chen, W.-H., Luo, G.-F., Lei, Q., Jia, H.-Z., Hong, S., Wang, Q.-R., Zhuo, R.-X., & Zhang, X.-Z.
Affiliations
  • Wuhan University (CN)
  • Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry
Corresponding author
Zhang, Xian-Zheng
Venue
Chemical Communications
Published
2015
Volume
51
Issue
3
Pages
465-468
ISSN
  • 1359-7345 (ISSN-L)
  • 1364-548X
OpenAlex
W2164840927
Cited by
115
References
27
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 16 · 2017: 11 · 2016: 15 · 2015: 9
FWCI
4.42
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (51125014 and 51233003)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, intracellular drug delivery, tumor targeting, receptor-mediated endocytosis, apoptosis, anticancer drug delivery
MeSH terms
Antineoplastic Agents, Cell Survival, Humans, Micelles, Models, Biological, Polymers, Drug Delivery Systems, Microscopy, Confocal, Matrix Metalloproteinase 2, Cell Line, Tumor

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