Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
Abstract
The design of internal stimuli-responsive nanocarriers has been extensively used for delivery of various active compounds including drugs, peptides and genes. These nanosystems are not only designed for improved solubility, enhanced bioavailability, and prolonged blood circulation time, furthermore, they can be tailored chemically to achieve selective drug release at the desired sites of action, which can enable them to bypass physiological or pathological obstacles and achieve enhanced therapeutic efficacy. This review presents current functional moieties responsive to a variety of internal stimuli, including pH, redox, enzyme, temperature. Their design strategies and biomedical applications are also highlighted in detail. It is expected that this review can provide inspiration and impetus for exploiting more promising internal stimuli-responsive nano-systems for drug delivery.
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Many redox-responsive nanoparticles have been investigated for the delivery of chemotherapeutic drugs to treat cancer, including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.
“For the delivery of chemotherapeutic drugs to treat cancer, many redox-responsive nanoparticles have been investigated recently,166 including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.167,168”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [168]
Cites
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆
Slowing, I. I., Vivero-Escoto, J. L., Wu, K. C. ‐., & Lin, V. S. ‐. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.012 · Cited by 2,655 · see citing works
A review of stimuli-responsive nanocarriers for drug and gene delivery
Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,157 · see citing works
Nanocarriers’ entry into the cell: relevance to drug delivery
Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,549 · see citing works
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
Fleige, E., Quadir, M., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,114 · see citing works
Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004 · see citing works
Recent progress in tumor pH targeting nanotechnology
Lee, E. S., Gao, Z., & Bae, Y. H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.003 · Cited by 866 · see citing works
Stimuli-responsive polymers and their applications in drug delivery
Bawa, P., Pillay, V., Choonara, Y. E., & du Toit, L. C. (2009) · Biomedical Materials · doi:10.1088/1748-6041/4/2/022001 · Cited by 643 · see citing works
Midoux, P., Pichon, C., Yaouanc, J., & Jaffrès, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00288.x · Cited by 549 · see citing works
Zhu, L., Kate, P., & Torchilin, V. P. (2012) · ACS Nano · doi:10.1021/nn300524f · Cited by 496 · see citing works
Jensen, F. V. (2009) · Wiley Interdisciplinary Reviews Computational Statistics · doi:10.1002/wics.48 · Cited by 486 · see citing works
Design and development of polymeric micelles with cleavable links for intracellular drug delivery
Wei, H., Zhuo, R., & Zhang, X. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.07.002 · Cited by 475 · see citing works
Stimuli‐Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery
Onaca, O., Enea, R., Hughes, D. W., & Meier, W. P. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800248 · Cited by 464 · see citing works
Luo, C., Sun, J., Liu, D., Sun, B., Miao, L., Musetti, S., Li, J., Han, X., Du, Y., Li, L., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b01632 · Cited by 444 · see citing works
Cholinesterase-Responsive Supramolecular Vesicle
Guo, D., Wang, K., Wang, Y., & Liu, Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303280r · Cited by 413 · see citing works
Aimetti, A. A., Machen, A. J., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.043 · Cited by 378 · see citing works
Poly (glutamic acid) – An emerging biopolymer of commercial interest
Bajaj, I. B., & Singhal, R. S. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.02.047 · Cited by 371 · see citing works
Chen, W., Zhong, P., Meng, F., Cheng, R., Deng, C., Feijén, J., & Zhong, Z. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.001 · Cited by 363 · see citing works
pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
Cai, X., Luo, Y., Zhang, W., Du, D., & Lin, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04933 · Cited by 361 · see citing works
Self-citationYu, M., Jambhrunkar, S., Thorn, P., Chen, J., Gu, W., & Yu, C. (2012) · Nanoscale · doi:10.1039/c2nr32145a · Cited by 336 · see citing works
Dynamic Diselenide Bonds: Exchange Reaction Induced by Visible Light without Catalysis
Ji, S., Cao, W., Yu, Y., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403442 · Cited by 336 · see citing works
Ünsoy, G., Khodadust, R., Yalçın, S., Mutlu, P., & Gündüz, U. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.05.021 · Cited by 332 · see citing works
Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound
Gao, Z., Fain, H. D., & Rapoport, N. Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.021 · Cited by 328 · see citing works
Bernardos, A., Mondragón, L., Aznar, E., Marcos, M. D., Martínez‐Máñez, R., Sancenón, F., Soto, J., Baviera, J. M. B., Pérez‐Payá, E., Guillem, C., et al. (2010) · ACS Nano · doi:10.1021/nn101499d · Cited by 311 · see citing works
Wang, D., Zhou, J., Chen, R., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.027 · Cited by 299 · see citing works
Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers
Li, Y., Xiao, K., Zhu, W., Deng, W., & Lam, K. S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.008 · Cited by 292 · see citing works
Bae, Y., Nishiyama, N., & Kataoka, K. (2007) · Bioconjugate Chemistry · doi:10.1021/bc060401p · Cited by 278 · see citing works
Responsive polymeric delivery systems
Kost, J., & Langer, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.014 · Cited by 268 · see citing works
Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria
Jean, S. R., Ahmed, M., Lei, E. K., Wisnovsky, S., & Kelley, S. O. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00277 · Cited by 252 · see citing works
Chen, W., Meng, F., Li, F., Ji, S., & Zhong, Z. (2009) · Biomacromolecules · doi:10.1021/bm900074d · Cited by 241 · see citing works
Lin, Z., Gao, W., Hu, H., Ma, K., He, B., Dai, W., Wang, X., Wang, J., Zhang, X., & Zhang, Q. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.026 · Cited by 215 · see citing works
Huang, S., Shao, K., Liu, Y., Kuang, Y., Li, J., An, S., Guo, Y., Ma, H., & Jiang, C. (2013) · ACS Nano · doi:10.1021/nn400548g · Cited by 213 · see citing works
Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo
Liu, J., Zhang, B., Luo, Z. Y., et al. (2015) · Nanoscale · doi:10.1039/c5nr00072f · Cited by 193 · see citing works
Li, Q., Sun, Y., Sun, Y., Wen, J.-J., Zhou, Y. T., Bing, Q., Isaacs, L., Jin, Y., Gao, H., & Yang, Y. (2014) · Chemistry of Materials · doi:10.1021/cm503304p · Cited by 192 · see citing works
Harnoy, A. J., Rosenbaum, I., Tirosh, E., Ebenstein, Y., Shaharabani, R., Beck, R., & Amir, R. J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja413036q · Cited by 191 · see citing works
Wu, L., Zou, Y., Deng, C., Cheng, R., Meng, F., & Zhong, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.035 · Cited by 187 · see citing works
Bioresponsive Hyaluronic Acid‐Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery
Chen, Z., Li, Z., Lin, Y., Yin, M., Ren, J., & Qu, X. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201202038 · Cited by 180 · see citing works
Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells
Sarkar, A., Ghosh, S., Chowdhury, S., Pandey, B., & Sil, P. C. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.001 · Cited by 180 · see citing works
Jiang, L., Zhou, Q., Mu, K., Xie, H., Zhu, Y., Zhu, W., Zhao, Y., Xu, H., & Yang, X. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.078 · Cited by 165 · see citing works
Rejinold, N. S., Sreerekha, P. R., Chennazhi, K. P., Nair, S. V., & Jayakumar, R. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.04.008 · Cited by 164 · see citing works
Popat, A., Ross, B. P., Liu, J., Jambhrunkar, S., Kleitz, F., & Qiao, S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206416 · Cited by 164 · see citing works
Lei, Q., Qiu, W., Hu, J., Cao, P., Zhu, C., Cheng, H. L., & Zhang, X. (2016) · Small · doi:10.1002/smll.201601137 · Cited by 163 · see citing works
A pH‐Responsive Superamphiphile Based on Dynamic Covalent Bonds
Wang, C., Wang, G., Wang, Z., & Zhang, X. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201003502 · Cited by 151 · see citing works
Baier, G., Cavallaro, A., Vasilev, K. A., et al. (2013) · Biomacromolecules · doi:10.1021/bm302003m · Cited by 147 · see citing works
Wu, X., Wang, Z., Zhu, D., Zong, S., Yang, L., Zhong, Y., & Cui, Y. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am403092m · Cited by 146 · see citing works
Thermal Cycling Enhances the Accumulation of a Temperature-Sensitive Biopolymer in Solid Tumors
Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., & Chilkoti, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4444 · Cited by 145 · see citing works
Redox-responsive polyanhydride micelles for cancer therapy
Wang, J., Yang, G., Guo, X., Tang, Z., Zhong, Z. A., & Zhou, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.025 · Cited by 139 · see citing works
Basel, M. T., Shrestha, T. B., Troyer, D. L., & Bossmann, S. H. (2011) · ACS Nano · doi:10.1021/nn103362n · Cited by 139 · see citing works
Zhu, L., Wang, D., Wei, X., Zhu, X., Li, J., Tu, C., Su, Y., Wu, J., Zhu, B., & Yan, D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.02.015 · Cited by 138 · see citing works
Cheng, Y., Hao, J., Lee, L. A., Biewer, M. C., Wang, Q., & Stefan, M. C. (2012) · Biomacromolecules · doi:10.1021/bm300823y · Cited by 135 · see citing works
Smart pH/Redox Dual-Responsive Nanogels for On-Demand Intracellular Anticancer Drug Release
Yang, H., Wang, Q., HUANG, S. H., Xiao, A., Li, F., Gan, L., & Yang, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01602 · Cited by 135 · see citing works
PDEPT: polymer-directed enzyme prodrug therapy
Satchi, R., Connors, T. A., & Duncan, R. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2026 · Cited by 130 · see citing works
Transferrin-Conjugated Pluronic Niosomes as a New Drug Delivery System for Anticancer Therapy
Tavano, L., Muzzalupo, R., Mauro, L., et al. (2013) · Langmuir · doi:10.1021/la4021383 · Cited by 129 · see citing works
A Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors
Sethuraman, V. A., Lee, M. C., & Bae, Y. H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9480-4 · Cited by 128 · see citing works
pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
Khanal, S., Adhikari, U., Rijal, N. P., Bhattarai, S. R., Sankar, J., & Bhattarai, N. (2016) · Journal of Functional Biomaterials · doi:10.3390/jfb7030021 · Cited by 121 · see citing works
Nanomedicine approaches in vascular disease: a review
Gupta, A. S. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.04.001 · Cited by 120 · see citing works
pH Responsive micelle self-assembled from a new amphiphilic peptide as anti-tumor drug carrier
Liang, J., Wu, W., Xu, X., Zhuo, R., & Zhang, X. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.10.037 · Cited by 114 · see citing works
Liu, Y., Ding, X., Li, J., et al. (2015) · Nanotechnology · doi:10.1088/0957-4484/26/14/145102 · Cited by 112 · see citing works
Redox-sensitive polymeric nanoparticles for drug delivery
Cho, H., Bae, J., Garripelli, V. K., Anderson, J. M., Jun, H., & Jo, S. (2012) · Chemical Communications · doi:10.1039/c2cc31463k · Cited by 111 · see citing works
A Collagen-Mimic Dendrimer Capable of Controlled Release
Kojima, C., Tsumura, S., Harada, A., & Kono, K. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809639c · Cited by 111 · see citing works
A novel thermo-sensitive hydrogel based on thiolated chitosan/hydroxyapatite/beta-glycerophosphate
Liu, X., Chen, Y., Huang, Q., He, W., Feng, Q., & Yu, B. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.03.065 · Cited by 103 · see citing works
Designing switchable nanosystems for medical application
Lehner, R., Wang, X., Wolf, M., & Hunziker, P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.040 · Cited by 100 · see citing works
pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers
Tian, H., Guo, Z., Lin, L., Jiao, Z., Chen, J., Gao, S., Zhu, X., & Chen, X. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.008 · Cited by 100 · see citing works
Steinhilber, D., Sisson, A. L., Mangoldt, D., Welker, P., Licha, K., & Haag, R. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000410 · Cited by 100 · see citing works
Li, X., Zhao, W., Liu, X., et al. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.036 · Cited by 99 · see citing works
Leal, M. P., Torti, A. M., Riedinger, A., Fleur, R. L., Petti, D., Cingolani, R., Bertacco, R., & Pellegrino, T. (2012) · ACS Nano · doi:10.1021/nn3028425 · Cited by 97 · see citing works
Zhao, F., Shen, G., Chen, C., Xing, R., Zou, Q., Ma, G., & Yan, X. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201400348 · Cited by 96 · see citing works
Dual Redox Responsive Coassemblies of Diselenide-Containing Block Copolymers and Polymer Lipids
Wang, L., Cao, W., Yi, Y., & Xu, H. (2014) · Langmuir · doi:10.1021/la501054z · Cited by 96 · see citing works
Yang, Y., Aw, J., Chen, K., Liu, F., Padmanabhan, P., Hou, Y., Cheng, Z., & Xing, B. (2011) · Chemistry - An Asian Journal · doi:10.1002/asia.201000905 · Cited by 93 · see citing works
Li, S., Cheng, H. B., Qiu, W., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b08637 · Cited by 92 · see citing works
Deka, S. R., Quarta, A., Corato, R. D., Riedinger, A., Cingolani, R., & Pellegrino, T. (2010) · Nanoscale · doi:10.1039/c0nr00570c · Cited by 89 · see citing works
Wan, Y., Han, J., Fan, G., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.12.051 · Cited by 88 · see citing works
Mondragón, L., Mas, N., Ferragud, V., de la Torre, C., Agostini, A., Martínez‐Máñez, R., Sancenón, F., Amorós, P., Pérez‐Payá, E., & Orzáez, M. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201400148 · Cited by 88 · see citing works
Chen, M., He, X., Wang, K., et al. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21268h · Cited by 86 · see citing works
Murali, R., Ponraj, V., & Thanikaivelan, P. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.076 · Cited by 85 · see citing works
Davaran, S., Alimirzalu, S., Nejati‐Koshki, K., et al. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.1.49 · Cited by 85 · see citing works
Carmona‐Moran, C. A., Zavgorodnya, O., Penman, A. D., Kharlampieva, E., Bridges, S. L., Hergenrother, R. W., Singh, J. A., & Wick, T. M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.062 · Cited by 84 · see citing works
A pH-sensitive charge-conversion system for doxorubicin delivery
Guan, X., Li, Y., Jiao, Z., Chen, J., Guo, Z., Tian, H., & Chen, X. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.04.047 · Cited by 83 · see citing works
Lin, C.-J., Kuan, C., Wang, L.-W., Wu, H., Chen, Y., Chang, C., Huang, R.-Y., & Wang, T. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.005 · Cited by 83 · see citing works
Jia, L., Li, Z., Zhang, D., Zhang, Q., Shen, J., Guo, H., Tian, X., Liu, G., Zheng, D., & Qi, L. (2012) · Polymer Chemistry · doi:10.1039/c2py20781h · Cited by 80 · see citing works
Ayano, E., Karaki, M., Ishihara, T., Kanazawa, H., & Okano, T. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.10.003 · Cited by 79 · see citing works
Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers
Zong, W., Hu, Y., Su, Y., Luo, N., Zhang, X., Li, Q., & Han, X. (2016) · Journal of Microencapsulation · doi:10.3109/02652048.2016.1156176 · Cited by 78 · see citing works
Cuggino, J. C., I., C. I. A., Strumia, M. C., et al. (2011) · Soft Matter · doi:10.1039/c1sm06357j · Cited by 77 · see citing works
Multi-functional vesicles for cancer therapy: The ultimate magic bullet
Tavano, L., & Muzzalupo, R. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.07.060 · Cited by 77 · see citing works
Habraken, G. J. M., Peeters, M., Thornton, P. D., et al. (2011) · Biomacromolecules · doi:10.1021/bm2010033 · Cited by 76 · see citing works
Herlambang, S., Kumagai, M., Nomoto, T., Horie, S., Fukushima, S., Oba, M., Miyazaki, K., Morimoto, Y., Nishiyama, N., & Kataoka, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.019 · Cited by 76 · see citing works
pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting
Coen, R. D., Vanparijs, N., Risseeuw, M., et al. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00685 · Cited by 76 · see citing works
Constantin, M., Bucătariu, S., Harabagiu, V., Popescu, I., Ascenzi, P., & Fundueanu, G. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.05.005 · Cited by 72 · see citing works
Wang, S., Wang, H., Liu, Z., et al. (2014) · Nanoscale · doi:10.1039/c4nr00843j · Cited by 72 · see citing works
PEGylated thermo-sensitive poly(amidoamine) dendritic drug delivery systems
Zhao, Y., Fan, X., Liu, D., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.005 · Cited by 69 · see citing works
Wei, W., Qi, X., Liu, Y., et al. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.11.007 · Cited by 69 · see citing works
Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery
Garripelli, V. K., Kim, J.-K., Son, S., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.02.005 · Cited by 68 · see citing works
Biodegradable branched poly(ethylenimine sulfide) for gene delivery
Koo, H., Jin, G., Kang, H.-S., Lee, Y., Nam, K., Bai, C. Z., & Park, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.004 · Cited by 67 · see citing works
Xu, Z., Wang, D., Xu, S. H., Liu, X., Zhang, X., & Zhang, H. (2013) · Chemistry - An Asian Journal · doi:10.1002/asia.201301030 · Cited by 67 · see citing works
Song, F., Wang, X., & Wang, Y. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.08.015 · Cited by 67 · see citing works
Zhao, X., Li, Z., Pan, H., Liu, W., Lv, M., Leung, F. K. L., & Lu, W. W. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.01.039 · Cited by 67 · see citing works
pH and redox-responsive mixed micelles for enhanced intracellular drug release
Cai, M., Zhu, K. N., Qiu, Y., Liu, X., Chen, Y., & Luo, X. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.01.012 · Cited by 65 · see citing works
Burga, R. A., Patel, S., Bollard, C. M., et al. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0160 · Cited by 64 · see citing works
Enzyme-Responsive Polymeric Supra-Amphiphiles Formed by the Complexation of Chitosan and ATP
Kang, Y., Wang, C., Liu, K., Wang, Z., & Zhang, X. (2012) · Langmuir · doi:10.1021/la303271f · Cited by 63 · see citing works
Zhao, J., Liu, J., Xu, S., et al. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am404213w · Cited by 62 · see citing works
Yang, Q., Li, L., Sun, W., Zhou, Z., & Huang, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b02403 · Cited by 61 · see citing works
Pradhan, L., Srivastava, R., & Bahadur, D. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.011 · Cited by 59 · see citing works
Shen, H., Shi, H., Ma, K., et al. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.12.024 · Cited by 58 · see citing works
Biocleavable graphene oxide based-nanohybrids synthesized via ATRP for gene/drug delivery
Yang, X., Zhao, N., & Xu, F. (2014) · Nanoscale · doi:10.1039/c4nr00907j · Cited by 58 · see citing works
Zhang, Y., Meng, D., Shi, J., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s98832 · Cited by 57 · see citing works
The potential of pH-responsive PEG-hyperbranched polyacylhydrazone micelles for cancer therapy
Yu, J., Deng, H., Xie, F., Chen, W., Zhu, B., & Xu, Q. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.074 · Cited by 56 · see citing works
Herranz‐Blanco, B., Shahbazi, M., Correia, A. M. R., Balasubramanian, V., Kohout, T., Hirvonen, J. J., & Santos, H. A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600160 · Cited by 56 · see citing works
pH-responsive release of proteins from biocompatible and biodegradable reverse polymer micelles
Koyamatsu, Y., Hirano, T., Kakizawa, Y., Okano, F., Takarada, T., & Maeda, M. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.035 · Cited by 55 · see citing works
A pH- and thermo-responsive poly(amino acid)-based drug delivery system
Liu, N., Li, B., Gong, C., Liu, Y., Wang, Y., & Wu, G. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.09.057 · Cited by 55 · see citing works
Davoodi, P., Srinivasan, M. P., & Wang, C. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.003 · Cited by 55 · see citing works
In Vitro Evaluation of pH-Sensitive Polymer/Niosome Complexes
Francis, M. F., Dhara, G., Winnik, F. M., et al. (2001) · Biomacromolecules · doi:10.1021/bm010036z · Cited by 53 · see citing works
Xing, H., Zhang, C. L., Ruan, G., Zhang, J., Hwang, K., & Lu, Y. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04031 · Cited by 53 · see citing works
Xing, Y., Wang, C., Han, P., Wang, Z., & Zhang, X. (2012) · Langmuir · doi:10.1021/la300612k · Cited by 53 · see citing works
Ultra‐bright and stimuli‐responsive fluorescent nanoparticles for bioimaging
Battistelli, G., Cantelli, A., Guidetti, G., Manzi, J., & Montalti, M. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1351 · Cited by 52 · see citing works
Gong, Y., Hu, Q., Wang, C., et al. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b03883 · Cited by 50 · see citing works
pH-Responsive Nanoemulsions for Controlled Drug Release
Liu, F., Lin, S., Zhang, Z., et al. (2014) · Biomacromolecules · doi:10.1021/bm4018484 · Cited by 49 · see citing works
Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery
Chang, C., Wei, H., Wu, D.-Q., Yang, B., Chen, N., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.038 · Cited by 46 · see citing works
Théron, C., Gallud, A., Carcel, C., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402864 · Cited by 46 · see citing works
Huo, M., Liu, Y., Wang, L., Yin, T., Qin, C., Xiao, Y., Yin, L., Liu, J., & Zhou, J. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00696 · Cited by 46 · see citing works
Yang, L., Wang, J., Xie, C., et al. (2013) · The Journal of Gene Medicine · doi:10.1002/jgm.2726 · Cited by 44 · see citing works
Candel, I., Aznar, E., Mondragón, L., et al. (2012) · Nanoscale · doi:10.1039/c2nr32062b · Cited by 44 · see citing works
Gupta, J., Mohapatra, J., Bhargava, P., et al. (2015) · Dalton Transactions · doi:10.1039/c5dt04135j · Cited by 43 · see citing works
pH-responsive zwitterionic polypeptide as a platform for anti-tumor drug delivery
Liu, N., Han, J., Zhang, X., Yang, Y., Liu, Y., Wang, Y., & Wu, G. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.05.027 · Cited by 43 · see citing works
Rejinold, N. S., Baby, T., Chennazhi, K. P., et al. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.10.015 · Cited by 42 · see citing works
Mas, N., Agostini, A., Mondragón, L., et al. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201202740 · Cited by 42 · see citing works
PH-sensitive, polymer modified, plasma stable niosomes: promising carriers for anti-cancer drugs
Tila, D., Yazdani-Arazi, S. N., Ghanbarzadeh, S., Arami, S., & Pourmoazzen, Z. (2015) · Europe PMC (PubMed Central) · doi:10.17179/excli2013-609 · Cited by 42 · see citing works
Polymer Therapeutics Designed for a Combination Therapy of Hormone‐Dependent Cancer
Vicent, M. J., Greco, F., Nicholson, R. I., et al. (2005) · Angewandte Chemie · doi:10.1002/ange.200462960 · Cited by 42 · see citing works
John, J. V., Chung, C., Johnson, R. P., et al. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01474 · Cited by 41 · see citing works
León, A. D. S. D., Molina, M. A., Wedepohl, S., et al. (2016) · Langmuir · doi:10.1021/acs.langmuir.5b04166 · Cited by 38 · see citing works
Glaser, V., Martins, R. D. P., Vieira, A. J. H., Oliveira, E. D. M., Straliotto, M. R., Mukdsi, J. H., Torres, A. I., Bem, A. F. D., Farina, M., da Rocha, J. B. T., et al. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1870-9 · Cited by 37 · see citing works
Li, X., Tang, T., Zhou, Y., et al. (2013) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2013.09.024 · Cited by 36 · see citing works
Wen, Y., & Oh, J. K. (2013) · RSC Advances · doi:10.1039/c3ra46072j · Cited by 36 · see citing works
Xiao, Y., Wang, T., Cao, Y., Wang, X., Ye, Z., Liu, Y., & Huo, Q. (2015) · Dalton Transactions · doi:10.1039/c4dt03758h · Cited by 36 · see citing works
Design of Chitosan-Based Nanoformulations for Efficient Intracellular Release of Active Compounds
Du, H., Yang, X., & Zhai, G. (2014) · Nanomedicine · doi:10.2217/nnm.14.8 · Cited by 33 · see citing works
Self-citationZhang, X., Liu, B., Yang, Z., Zhang, C., Li, H., Luo, X., Luo, H., Gao, D., Jiang, Q. Y., Liu, J., et al. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.12.029 · Cited by 33 · see citing works
Wei, X., Han, C., Geng, P., et al. (2015) · Soft Matter · doi:10.1039/c5sm02247a · Cited by 33 · see citing works
He, M., Potuck, A., Kohn, J. C., Fung, K., Reinhart‐King, C. A., & Chu, C. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01449 · Cited by 33 · see citing works
Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems
Adeli, M., Fard, A. K., Abedi, F., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.05.013 · Cited by 28 · see citing works
A pH‐responsive carboxymethyl dextran‐based conjugate as a carrier of docetaxel for cancer therapy
Han, H. S., Lee, M., An, J. Y., et al. (2015) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33581 · Cited by 27 · see citing works
Mengesha, A., Wydra, R. J., Hilt, J. Z., et al. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1230-1 · Cited by 26 · see citing works
Nie, J., Wang, Y., & Wang, W. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.021 · Cited by 26 · see citing works
Peng, S., Thomas, M., Ruszkiewicz, A. R., et al. (2013) · ANZ Journal of Surgery · doi:10.1111/ans.12444 · Cited by 24 · see citing works
Tschiche, A., Thota, B. N. S., Neumann, F., et al. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201500363 · Cited by 22 · see citing works
Lim, S., Jeong, Y., Moon, K., Ryu, H., Jin, Y., Jin, S., Jung, T., Kim, I., Kang, S.-S., & Jung, S. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.11.023 · Cited by 20 · see citing works
Jin, H., Lu, J., & Wu, X. Z. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.04.012 · Cited by 20 · see citing works
Choi, S., Kim, J., Hwang, D. Y., Park, H., Ryu, J., Kwak, S. K., & Park, S. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04476 · Cited by 20 · see citing works
Clarhaut, J. A., Fraineau, S., Guilhot, J., et al. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.04.026 · Cited by 19 · see citing works
Eltohamy, M. R., Seo, J., Hwang, J., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.04.023 · Cited by 17 · see citing works
Liu, R., Sun, M., Liu, X., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.12.031 · Cited by 15 · see citing works
PEG-PLGA Nanoparticles Entrapping Doxorubicin Reduced Doxorubicin-Induced Cardiotoxicity in Rats
Mao, J. N., Li, A. J., Zhao, L., et al. (2014) · Advanced materials research · doi:10.4028/www.scientific.net/amr.912-914.263 · Cited by 14 · see citing works
Advances in the Targeting Molecules Modified Chitosan-Based Nanoformulations
Du, H., Cai, X., & Zhai, G. (2013) · Current Drug Targets · doi:10.2174/1389450111314090012 · Cited by 14 · see citing works
Self-citationThermo-Responsive Hydrogels for Ocular Drug Delivery
Kang‐Mieler, J. J., & Mieler, W. F. (2015) · Developments in ophthalmology · doi:10.1159/000434694 · Cited by 13 · see citing works
Mishina, M., Minamihata, K., Moriyama, K., & Nagamune, T. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00149 · Cited by 13 · see citing works
Platinum (IV)-coordinate polymers for cancer drug delivery
Yang, J. J., Mao, W., Sui, M., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.156 · Cited by 5 · see citing works
Bae, S.-B., & Lee, S.-W. (2015) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2015.11232 · Cited by 5 · see citing works
Heo, M. S., Seo, E. J., John, J. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.133 · Cited by 4 · see citing works
Chen, C.-Y. (2012) · Recent Patents on Nanotechnology · doi:10.2174/187221012800270144 · Cited by 4 · see citing works
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998 · see citing works
- Authors
- Liu, M., Du, H., Zhang, W., & Zhai, G.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Zhai, Guangxi
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 71
- Pages
- 1267-1280
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2553062788
- Cited by
- 235
- References
- 158
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 28 · 2020: 31 · 2019: 25 · 2018: 25 · 2017: 9
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Shandong Province, China (ZR2011HM026)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- stimuli-responsive nanocarriers, internal stimuli, drug delivery, pH-responsive, redox-responsive, enzyme-responsive, temperature-responsive, targeted drug release, bioavailability enhancement, blood circulation time, gene delivery, peptide delivery
- MeSH terms
- Animals, Delayed-Action Preparations, Drug Carriers, Humans, Hydrogen-Ion Concentration, Drug Design, Nanoparticles
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