Cited by 235Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications

Liu, Mengrui, Du, Hongliang, Zhang, Wenjia, Zhai, Guangxi·2017·Materials Science and Engineering: C

Abstract

The design of internal stimuli-responsive nanocarriers has been extensively used for delivery of various active compounds including drugs, peptides and genes. These nanosystems are not only designed for improved solubility, enhanced bioavailability, and prolonged blood circulation time, furthermore, they can be tailored chemically to achieve selective drug release at the desired sites of action, which can enable them to bypass physiological or pathological obstacles and achieve enhanced therapeutic efficacy. This review presents current functional moieties responsive to a variety of internal stimuli, including pH, redox, enzyme, temperature. Their design strategies and biomedical applications are also highlighted in detail. It is expected that this review can provide inspiration and impetus for exploiting more promising internal stimuli-responsive nano-systems for drug delivery.

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Crossref · 10.1016/j.msec.2016.11.030

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158 of 158 references verified0 citation errors · 0 not checkable

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  • Many redox-responsive nanoparticles have been investigated for the delivery of chemotherapeutic drugs to treat cancer, including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.

    “For the delivery of chemotherapeutic drugs to treat cancer, many redox-responsive nanoparticles have been investigated recently,166 including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.167,168”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [168]

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Authors
Liu, M., Du, H., Zhang, W., & Zhai, G.
Affiliations
Shandong University (CN)
Corresponding author
Zhai, Guangxi
Venue
Materials Science and Engineering: C
Publisher
Elsevier BV
Published
2017-02
Volume
71
Pages
1267-1280
ISSN
0928-4931 (ISSN-L)
OpenAlex
W2553062788
Cited by
235
References
158
Citations by year
2026: 24 · 2025: 23 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 28 · 2020: 31 · 2019: 25 · 2018: 25 · 2017: 9
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Materials Science and Engineering C (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Shandong Province, China (ZR2011HM026)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
stimuli-responsive nanocarriers, internal stimuli, drug delivery, pH-responsive, redox-responsive, enzyme-responsive, temperature-responsive, targeted drug release, bioavailability enhancement, blood circulation time, gene delivery, peptide delivery
MeSH terms
Animals, Delayed-Action Preparations, Drug Carriers, Humans, Hydrogen-Ion Concentration, Drug Design, Nanoparticles

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