The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glucose Oxidase–Polymer Nanogels for Synergistic Cancer-Starving and Oxidation Therapy
Abstract
Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide (H 2 O 2 ), which is potentially useful for synergistic cancer-starving and oxidation therapy. Herein we demonstrate a glucose-responsive nanomedicine made of GOX–polymer nanogels to regulate H 2 O 2 production for synergistic melanoma starving and oxidation therapy. GOX–polymer nanogels showed glucose-responsive H 2 O 2 -generating activity in vitro, improved stability, and considerably enhanced tumor retention as compared to native GOX. More importantly, they exhibited high antimelanoma efficacy and no obvious systemic toxicity, whereas native GOX was ineffective and systemically toxic at the same dose. This work paves the way for establishing an endogenous and noninvasive cancer treatment paradigm that is based on intratumoral glucose-responsive, H 2 O 2 -generating chemical reactions.
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Cites
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555
Cited by
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment
Fu, L.-H., Qi, C., Lin, J., & Huang, P. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00891k · Cited by 783
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy
Fu, L., Qi, C., Hu, Y., Lin, J., & Huang, P. (2019) · Advanced Materials · doi:10.1002/adma.201808325 · Cited by 600
Yang, X., Yang, Y., Gao, F., Wei, J.-J., Qian, C.-G., & Sun, M.-J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00934 · Cited by 293
Metadata
- Authors
- Zhao, W., Hu, J., & Gao, W.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-07-05
- Volume
- 9
- Issue
- 28
- Pages
- 23528-23535
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2700421244
- Cited by
- 182
- References
- 1
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- closed
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