The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy
Abstract
Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in the context of cancer treatment due to its inherent biocompatibility and biodegradability, and its unique catalytic properties against β‐d‐glucose. GOx can effectively catalyze the oxidation of glucose into gluconic acid and hydrogen peroxide. This process depletes oxygen levels, resulting in elevated acidity, hypoxia, and oxidative stress in the tumor microenvironment. All of these changes can be readily harnessed to develop a multimodal synergistic cancer therapy by combining GOx with other therapeutic approaches. Herein, the representative studies of GOx‐instructed multimodal synergistic cancer therapy are introduced, and their synergistic mechanisms are discussed systematically. The current challenges and future prospects to advance the development of GOx‐based nanomedicines in this cutting‐edge research area are highlighted.
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Cited by
Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202006892 · Cited by 820
Self-citationConquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Self-citationZhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy
Zhang, J., Lin, Y., Lin, Z., Wei, Q., Qian, J., Ruan, R., Jiang, X., Hou, L., Song, J., Ding, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103444 · Cited by 292
Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Yao, X., Li, W., Fang, D., Xiao, C., Wu, X., Li, M., & Luo, Z. (2021) · Advanced Science · doi:10.1002/advs.202100997 · Cited by 282
Metadata
- Authors
- Fu, L., Qi, C., Hu, Y., Lin, J., & Huang, P.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-03-25
- Volume
- 31
- Issue
- 21
- Pages
- e1808325-e1808325
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2924970449
- Cited by
- 600
- References
- 60
- FWCI
- 25.13
- Type
- journal article
- Language
- en
- Open access
- closed
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