The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors
Abstract
Nanozymes as artificial enzymes that mimicked natural enzyme-like activities have received great attention in cancer diagnosis and therapy. Biomimetic nanozymes require more consideration regarding complicated tumor microenvironments to mimic biological enzymes, thus achieving superior nanozyme activity in vivo. Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO 2 ) by mutual promotion for maximizing the enzymatic activity of MnO 2 and GOx. Under hypoxia environment, we observed that MnO 2 could react with endogenous H 2 O 2 to produce O 2 for enhancing the catalytic efficiency of GOx for starvation therapy. Meanwhile, we confirmed that glucose oxidation generated gluconic acid and further improved the catalytic efficiency of MnO 2 subsequently. The biochemical reaction cycle, consisting of MnO 2, O 2, GOx, and H +, was triggered by the tumor microenvironment and accelerated each other so as to achieve self-supplied H + and accelerate O 2 generation, enhancing the starvation therapy, alleviating tumor hypoxia and accelerating the reactive oxygen species generation in photodynamic therapy. This biomimetic hybrid nanozyme would further facilitate the development of biological nanozymes for cancer treatment.
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Cites
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Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia
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Targeting drugs to tumours using cell membrane-coated nanoparticles
Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980
A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications
Liu, Q., Zhang, A., Wang, R., Zhang, Q., & Cui, D. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00674-8 · Cited by 745
Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
Self-citationNanozymes: Activity origin, catalytic mechanism, and biological application
Yang, W., Yang, X., Zhu, L., Chu, H., Li, X., & Xu, W. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214170 · Cited by 470
Self-citationReactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment
Zhang, C., Wang, X., Du, J., Gu, Z., & Zhao, Y. (2021) · Advanced Science · doi:10.1002/advs.202002797 · Cited by 401
Metadata
- Authors
- Yang, X., Yang, Y., Gao, F., Wei, J.-J., Qian, C.-G., & Sun, M.-J.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-06-10
- Volume
- 19
- Issue
- 7
- Pages
- 4334-4342
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2951928817
- Cited by
- 293
- References
- 46
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, X., Yang, Y., Gao, F., Wei, J.-J., Qian, C.-G., & Sun, M.-J. (2019). Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors. Nano Letters. https://doi.org/10.1021/acs.nanolett.9b00934
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