The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing
Open accessAbstract
pH and glucose dual-responsive injectable hydrogels were prepared through the cross-linking of Schiff's base and phenylboronate ester using phenylboronic-modified chitosan, poly(vinyl alcohol) and benzaldehyde-capped poly(ethylene glycol). Protein drugs and live cells could be incorporated into the hydrogels during the in situ cross-linking, displaying sustained and pH/glucose-triggered drug release from the hydrogels and cell viability and proliferation in the three-dimensional hydrogel matrix as well. Hence, the hydrogels with insulin and fibroblasts were considered as bioactive dressings for diabetic wound healing. A streptozotocin-induced diabetic rat model was used to evaluate the efficacy of hydrogel dressings in wound repair. The results revealed that the incorporation of insulin and L929 in the hydrogels could promote neovascularization and collagen deposition and enhance the wound-healing process of diabetic wounds. Thus, the drug- and cell-loaded hydrogels have promising potential in wound healing as a medicated system for various therapeutic proteins and live cells.
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Cites
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
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Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,639
Biodegradable block copolymers as injectable drug-delivery systems
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Concise Review: Role of Mesenchymal Stem Cells in Wound Repair
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Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review
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Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Zhu, Y., Zhang, J., Song, J., Yang, J., Du, Z., Zhao, W., Guo, H., Wen, C., Li, Q., Sui, X., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201905493 · Cited by 538
Zhao, Y., Li, Z., Song, S., Yang, K., Liu, H., Yang, Z., Wang, J., Yang, B., & Lin, Q. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901474 · Cited by 528
Recent advances of injectable hydrogels for drug delivery and tissue engineering applications
Sun, Y., Nan, D., Jin, H., & Qu, X. (2020) · Polymer Testing · doi:10.1016/j.polymertesting.2019.106283 · Cited by 227
In situ formation of injectable hydrogels for chronic wound healing
Gao, Y., Li, Z., Huang, J., Zhao, M., & Wu, J. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01074j · Cited by 189
Metadata
- Authors
- Zhao, L., Niu, L., Liang, H., Tan, H., Liu, C., & Zhu, F.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-10-23
- Volume
- 9
- Issue
- 43
- Pages
- 37563-37574
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2761111959
- Cited by
- 363
- References
- 52
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, L., Niu, L., Liang, H., Tan, H., Liu, C., & Zhu, F. (2017). pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.7b09395
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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