The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Concise Review: Role of Mesenchymal Stem Cells in Wound Repair
Open accessAbstract
Wound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases. The beneficial effect of exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate stalled healing processes. Recent studies revealed that human placental membranes are a rich source of MSCs for tissue regeneration and repair. This review provides a concise summary of current knowledge of biological properties of MSCs and describes the use of MSCs for wound healing. In particular, the scope of this review focuses on the role MSCs have in each phase of the wound-healing process. In addition, characterization of MSCs containing skin substitutes is described, demonstrating the presence of key growth factors and cytokines uniquely suited to aid in wound repair.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Chronic Wound Pathogenesis and Current Treatment Strategies: A Unifying Hypothesis
Mustoe, T. A., O??Shaughnessy, K., & Kloeters, O. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225431.63010.1b · Cited by 653
Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair
Hocking, A. M., & Gibran, N. S. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.009 · Cited by 408
Yager, D. R., Zhang, L.-Y., Liang, H.-X., Diegelmann, R. F., & Cohen, I. K. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12365637 · Cited by 389
MMP-8 Is the Predominant Collagenase in Healing Wounds and Nonhealing Ulcers
Nwomeh, B. C., Liang, H.-X., Cohen, I. K., & Yager, D. R. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5495 · Cited by 357
Dash, N. R., Dash, S. N., Routray, P., Mohapatra, S., & Mohapatra, P. C. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0872 · Cited by 339
Cited by
Apoptotic cell: linkage of inflammation and wound healing
Wu, Y.-S., & Chen, S.-N. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00001 · Cited by 500
Zhao, L., Niu, L., Liang, H., Tan, H., Liu, C., & Zhu, F. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09395 · Cited by 363
Santos, J. M., Camões, S. P., Filipe, E., Cipriano, M., Barcia, R. N., Filipe, M., Teixeira, M., Simões, S., Gaspar, M., Mosqueira, D., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0082-5 · Cited by 196
The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146
Role of inflammation in the aging bones
Abdelmagid, S. M., Barbe, M. F., & Safadi, F. F. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.11.011 · Cited by 134
Metadata
- Authors
- Maxson, S., Lopez, E. A., Yoo, D., Danilkovitch-Miagkova, A., & LeRoux, M. A.
- Venue
- Stem Cells Translational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-01
- Volume
- 1
- Issue
- 2
- Pages
- 142-149
- ISSN
- 2157-6564 (ISSN-L)
- 2157-6580
- OpenAlex
- W2153405392
- Cited by
- 809
- References
- 11
- FWCI
- 46.43
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Concise Review: Role of Mesenchymal Stem Cells in Wound Repair. https://app.cochat.ai/papers/10.5966/sctm.2011-0018
- The paper
- Maxson, S., Lopez, E. A., Yoo, D., Danilkovitch-Miagkova, A., & LeRoux, M. A. (2012). Concise Review: Role of Mesenchymal Stem Cells in Wound Repair. Stem Cells Translational Medicine. https://doi.org/10.5966/sctm.2011-0018
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
